This domain is found in Maternal embryonic leucine zipper kinase from humans (MELK) and similar proteins from animals. MELK is a member of the snf1/AMPK family of serine-threonine kinases that has been associated with various cellular processes, incl ...
This domain is found in Maternal embryonic leucine zipper kinase from humans (MELK) and similar proteins from animals. MELK is a member of the snf1/AMPK family of serine-threonine kinases that has been associated with various cellular processes, including stem cell renewal, cell cycle progression, and pre-mRNA splicing. It is upregulated in several types of tumour. MELK is organised into three domains: an N-terminal kinase domain (Pfam:PF00069), a ubiquitin associated (UBA) domain (this entry) and a C-terminal kinase associated domain (KA1, Pfam:PF02149). This domain adopts a compact configuration consisting of three alpha-helices organised in a "U"-shaped fold, with the first helix antiparallel to the third one [1-5].