5ML9

Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer F4, a specific binding protein which blocks IgG binding to the receptor.

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	I-set_4	e5ml9A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_4	ECOD (1.6)
A	Ig_2_1	e5ml9A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Ig_2_1	ECOD (1.6)
B	Cystatin	e5ml9B1	A: a+b two layers	X: Cystatin-like	H: Cystatin/monellin (From Topology)	T: Cystatin/monellin	F: Cystatin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13895	Immunoglobulin domain (Ig_2)	Immunoglobulin domain	This domain contains immunoglobulin-like domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Low affinity immunoglobulin gamma Fc region receptor III-A	molecular transducer activity immunoglobulin receptor activity transmembrane signaling receptor activity signaling receptor activity IgG receptor activity immune receptor activity protein-containing complex binding binding immunoglobulin binding IgG binding low-affinity IgG receptor activity	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity response to stimulus myeloid leukocyte mediated immunity inflammatory response to antigenic stimulus response to stress leukocyte mediated immunity antibody-dependent cellular cytotoxicity acute inflammatory response hypersensitivity defense response immune response leukocyte mediated cytotoxicity acute inflammatory response to antigenic stimulus adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity response to stimulus myeloid leukocyte mediated immunity inflammatory response to antigenic stimulus response to stress leukocyte mediated immunity antibody-dependent cellular cytotoxicity acute inflammatory response hypersensitivity defense response immune response leukocyte mediated cytotoxicity acute inflammatory response to antigenic stimulus immunoglobulin mediated immune response adaptive immune response immune effector process type II hypersensitivity immune system process type IIa hypersensitivity B cell mediated immunity cellular process inflammatory response cell killing cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling biological regulation cell communication Fc receptor signaling pathway immune response-regulating signaling pathway regulation of response to stimulus regulation of immune response regulation of immune system process signal transduction Fc-gamma receptor signaling pathway intracellular signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction multicellular organismal process positive regulation of cell population proliferation regulation of leukocyte activation positive regulation of biological process regulation of cell activation lymphocyte activation positive regulation of natural killer cell proliferation leukocyte proliferation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation lymphocyte proliferation positive regulation of leukocyte activation positive regulation of mononuclear cell proliferation regulation of multicellular organismal process positive regulation of immune system process regulation of natural killer cell activation positive regulation of cellular process regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation cell activation positive regulation of lymphocyte proliferation positive regulation of natural killer cell activation natural killer cell activation natural killer cell proliferation mononuclear cell proliferation regulation of cell population proliferation positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation positive regulation of multicellular organismal process regulation of lymphocyte activation regulation of natural killer cell proliferation calcium-mediated signaling regulated exocytosis cellular localization biological process involved in interspecies interaction between organisms transport cell activation involved in immune response leukocyte degranulation vesicle-mediated transport response to biotic stimulus localization secretion by cell natural killer cell activation involved in immune response leukocyte activation involved in immune response establishment of localization in cell innate immune response response to external biotic stimulus natural killer cell mediated immunity lymphocyte activation involved in immune response secretion response to other organism export from cell defense response to symbiont response to external stimulus establishment of localization exocytosis defense response to other organism natural killer cell degranulation natural killer cell mediated cytotoxicity macrophage activation myeloid leukocyte activation regulation of tumor necrosis factor production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process regulation of biosynthetic process tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process positive regulation of gene expression metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process	cell periphery protein-containing complex cellular anatomical structure plasma membrane protein complex membrane plasma membrane membrane protein complex Fc-gamma receptor III complex Fc receptor complex cell surface external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle cell periphery protein-containing complex cellular anatomical structure plasma membrane protein complex membrane plasma membrane membrane protein complex Fc-gamma receptor III complex Fc receptor complex cell surface external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle
B	Affimer F4 with specificity for Fc gamma receptor IIIa	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR050488	Immunoglobulin Fc region receptor	Family
A	IPR003599	Immunoglobulin domain subtype	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P08637	autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity Liver Cirrhosis, Experimental ulcerative colitis ankylosing spondylitis breast cancer central nervous system lupus HIV infectious disease plasma cell myeloma systemic lupus erythematosus autoimmune disease breast carcinoma Crohn disease inflammatory bowel disease lung adenocarcinoma mucocutaneous lymph node syndrome autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity Liver Cirrhosis, Experimental ulcerative colitis ankylosing spondylitis breast cancer central nervous system lupus HIV infectious disease plasma cell myeloma systemic lupus erythematosus autoimmune disease breast carcinoma Crohn disease inflammatory bowel disease lung adenocarcinoma mucocutaneous lymph node syndrome psoriasis Takayasu arteritis cancer Ebola hemorrhagic fever leukopenia lung carcinoma lymphatic system disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.