5NJA

E. coli Microcin-processing metalloprotease TldD/E with angiotensin analogue bound

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PmbA_TldD_3rd	e5njaA3	A: beta barrels	X: barrel domain in putative modulator of DNA gyrase, PmbA/TldD (From Topology)	H: barrel domain in putative modulator of DNA gyrase, PmbA/TldD (From Topology)	T: barrel domain in putative modulator of DNA gyrase, PmbA/TldD	F: PmbA_TldD_3rd	ECOD (1.6)
A	PmbA_TldD_2nd	e5njaA1	A: a+b two layers	X: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	H: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	T: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523)	F: PmbA_TldD_2nd	ECOD (1.6)
A	UNK_F_TYPE	e5njaA2	A: a+b two layers	X: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	H: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	T: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523)	F: UNK_F_TYPE	ECOD (1.6)
C	PmbA_TldD_3rd	e5njaC1	A: beta barrels	X: barrel domain in putative modulator of DNA gyrase, PmbA/TldD (From Topology)	H: barrel domain in putative modulator of DNA gyrase, PmbA/TldD (From Topology)	T: barrel domain in putative modulator of DNA gyrase, PmbA/TldD	F: PmbA_TldD_3rd	ECOD (1.6)
C	PmbA_TldD_2nd	e5njaC2	A: a+b two layers	X: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	H: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	T: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523)	F: PmbA_TldD_2nd	ECOD (1.6)
C	UNK_F_TYPE	e5njaC3	A: a+b two layers	X: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	H: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	T: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523)	F: UNK_F_TYPE	ECOD (1.6)
B	PmbA_TldD_3rd	e5njaB1	A: beta barrels	X: barrel domain in putative modulator of DNA gyrase, PmbA/TldD (From Topology)	H: barrel domain in putative modulator of DNA gyrase, PmbA/TldD (From Topology)	T: barrel domain in putative modulator of DNA gyrase, PmbA/TldD	F: PmbA_TldD_3rd	ECOD (1.6)
B	PmbA_TldD_1st	e5njaB2	A: a+b two layers	X: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	H: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	T: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523)	F: PmbA_TldD_1st	ECOD (1.6)
B	PmbA_TldD_2nd	e5njaB3	A: a+b two layers	X: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	H: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	T: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523)	F: PmbA_TldD_2nd	ECOD (1.6)
D	PmbA_TldD_3rd	e5njaD2	A: beta barrels	X: barrel domain in putative modulator of DNA gyrase, PmbA/TldD (From Topology)	H: barrel domain in putative modulator of DNA gyrase, PmbA/TldD (From Topology)	T: barrel domain in putative modulator of DNA gyrase, PmbA/TldD	F: PmbA_TldD_3rd	ECOD (1.6)
D	PmbA_TldD_1st	e5njaD1	A: a+b two layers	X: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	H: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	T: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523)	F: PmbA_TldD_1st	ECOD (1.6)
D	PmbA_TldD_2nd	e5njaD3	A: a+b two layers	X: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	H: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) (From Topology)	T: a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523)	F: PmbA_TldD_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.2290.10	Alpha Beta	2-Layer Sandwich	PmbA/TldD fold	PmbA/TldD superfamily	CATH (4.3.0)
D	3.30.2290.10	Alpha Beta	2-Layer Sandwich	PmbA/TldD fold	PmbA/TldD superfamily	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF19289	PmbA/TldA metallopeptidase C-terminal domain (PmbA_TldD_3rd)	PmbA/TldA metallopeptidase C-terminal domain	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the gl ...	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the glutamic acid is a substrate-binding residue and the two histidines are zinc ligands. The third zinc ligand is a cysteine, C-terminal to the HEXXXH motif. The TldE (also known as PmbA) by itself has no catalytic activity, does not bind zinc, and does not carry the HEXXXH motif [1]. TldD and TldE were originally identified as regulators of DNA gyrase. Later, they are shown to be metalloproteases involved in CcdA degradation [2-3].	Domain
A, C	PF19290	PmbA/TldA metallopeptidase central domain (PmbA_TldD_2nd)	PmbA/TldA metallopeptidase central domain	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the gl ...	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the glutamic acid is a substrate-binding residue and the two histidines are zinc ligands. The third zinc ligand is a cysteine, C-terminal to the HEXXXH motif. The TldE (also known as PmbA) by itself has no catalytic activity, does not bind zinc, and does not carry the HEXXXH motif [1]. TldD and TldE were originally identified as regulators of DNA gyrase. Later, they are shown to be metalloproteases involved in CcdA degradation [2-3].	Domain
A, C	PF01523	PmbA/TldA metallopeptidase domain 1 (PmbA_TldD_1st)	PmbA/TldA metallopeptidase domain 1	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the gl ...	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the glutamic acid is a substrate-binding residue and the two histidines are zinc ligands. The third zinc ligand is a cysteine, C-terminal to the HEXXXH motif. The TldE (also known as PmbA) by itself has no catalytic activity, does not bind zinc, and does not carry the HEXXXH motif [1]. TldD and TldE were originally identified as regulators of DNA gyrase. Later, they are shown to be metalloproteases involved in CcdA degradation [2-3].	Domain
B, D	PF19289	PmbA/TldA metallopeptidase C-terminal domain (PmbA_TldD_3rd)	PmbA/TldA metallopeptidase C-terminal domain	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the gl ...	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the glutamic acid is a substrate-binding residue and the two histidines are zinc ligands. The third zinc ligand is a cysteine, C-terminal to the HEXXXH motif. The TldE (also known as PmbA) by itself has no catalytic activity, does not bind zinc, and does not carry the HEXXXH motif [1]. TldD and TldE were originally identified as regulators of DNA gyrase. Later, they are shown to be metalloproteases involved in CcdA degradation [2-3].	Domain
B, D	PF19290	PmbA/TldA metallopeptidase central domain (PmbA_TldD_2nd)	PmbA/TldA metallopeptidase central domain	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the gl ...	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the glutamic acid is a substrate-binding residue and the two histidines are zinc ligands. The third zinc ligand is a cysteine, C-terminal to the HEXXXH motif. The TldE (also known as PmbA) by itself has no catalytic activity, does not bind zinc, and does not carry the HEXXXH motif [1]. TldD and TldE were originally identified as regulators of DNA gyrase. Later, they are shown to be metalloproteases involved in CcdA degradation [2-3].	Domain
B, D	PF01523	PmbA/TldA metallopeptidase domain 1 (PmbA_TldD_1st)	PmbA/TldA metallopeptidase domain 1	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the gl ...	This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the glutamic acid is a substrate-binding residue and the two histidines are zinc ligands. The third zinc ligand is a cysteine, C-terminal to the HEXXXH motif. The TldE (also known as PmbA) by itself has no catalytic activity, does not bind zinc, and does not carry the HEXXXH motif [1]. TldD and TldE were originally identified as regulators of DNA gyrase. Later, they are shown to be metalloproteases involved in CcdA degradation [2-3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Metalloprotease TldD	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding zinc ion binding	cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex catalytic complex peptidase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
E, F	HIS-PRO-PHE	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity angiotensin receptor binding type 1 angiotensin receptor binding G protein-coupled receptor binding type 2 angiotensin receptor binding enzyme regulator activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity angiotensin receptor binding type 1 angiotensin receptor binding G protein-coupled receptor binding type 2 angiotensin receptor binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity hormone activity	heart process multicellular organismal process system process regulation of biological process regulation of cardiac conduction regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process heart contraction blood circulation heart process multicellular organismal process system process regulation of biological process regulation of cardiac conduction regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process heart contraction blood circulation regulation of blood pressure regulation of biological quality regulation of defense response response to stimulus regulation of response to external stimulus defense response positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response renal system process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization gap junction assembly cellular component organization cellular component biogenesis cellular component assembly positive regulation of gap junction assembly cell junction assembly cellular component organization or biogenesis positive regulation of cellular process cell-cell junction assembly cell-cell junction organization positive regulation of cellular component biogenesis regulation of gap junction assembly regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cellular process regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone regulation of blood volume by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal regulation of systemic arterial blood pressure endocrine process regulation of renal output by angiotensin cellular response to stimulus regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of signal transduction regulation of transferase activity regulation of MAP kinase activity intracellular signal transduction negative regulation of cellular metabolic process regulation of primary metabolic process cell communication negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process intracellular signaling cassette negative regulation of protein modification process signal transduction phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of MAPK cascade regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphate metabolic process negative regulation of cell communication regulation of intracellular signal transduction negative regulation of protein serine/threonine kinase activity negative regulation of cellular process protein metabolic process negative regulation of macromolecule metabolic process regulation of signaling negative regulation of response to stimulus negative regulation of molecular function negative regulation of MAP kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of protein kinase activity negative regulation of signal transduction negative regulation of phosphorus metabolic process MAPK cascade regulation of cell communication regulation of phosphorylation negative regulation of phosphorylation negative regulation of MAPK cascade regulation of CoA-transferase activity positive regulation of molecular function positive regulation of transferase activity positive regulation of CoA-transferase activity positive regulation of catalytic activity regulation of localization renal sodium excretion inorganic ion homeostasis regulation of renal system process transport homeostatic process localization monoatomic ion homeostasis monoatomic cation homeostasis excretion sodium ion homeostasis regulation of transport secretion renal tubular secretion establishment of localization regulation of secretion regulation of renal sodium excretion chemical homeostasis regulation of excretion regulation of tube diameter regulation of tube size vascular process in circulatory system blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size cellular response to growth factor stimulus negative regulation of cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus neurotrophin signaling pathway enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus neurotrophin TRK receptor signaling pathway regulation of neurotrophin TRK receptor signaling pathway negative regulation of neurotrophin TRK receptor signaling pathway response to growth factor regulation of growth growth regulation of cell growth cell growth response to angiotensin response to hormone response to chemical response to peptide hormone response to oxygen-containing compound response to nitrogen compound cell-cell signaling regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death regulation of vasoconstriction cellular response to nitrogen compound angiotensin-activated signaling pathway cellular response to angiotensin cellular response to hormone stimulus cellular response to peptide hormone stimulus cellular response to oxygen-containing compound cellular response to chemical stimulus G protein-coupled receptor signaling pathway positive regulation of phosphorylation positive regulation of phosphate metabolic process positive regulation of metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of kinase activity regulation of protein tyrosine kinase activity positive regulation of protein metabolic process positive regulation of cellular metabolic process peptidyl-tyrosine modification positive regulation of protein modification process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein kinase activity positive regulation of protein tyrosine kinase activity regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation positive regulation of cell communication positive regulation of signal transduction positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway ERBB signaling pathway positive regulation of signaling positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process regulation of miRNA metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription cellular biosynthetic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of miRNA transcription regulation of aldosterone secretion regulation of steroid hormone secretion aldosterone secretion mineralocorticoid secretion regulation of hormone levels lipid transport regulation of corticosteroid hormone secretion endocrine hormone secretion lipid export from cell renin-angiotensin regulation of aldosterone production regulation of mineralocorticoid secretion regulation of endocrine process corticosteroid hormone secretion regulation of hormone secretion steroid hormone secretion regulation of lipid transport organic hydroxy compound transport hormone secretion secretion by cell regulation of secretion by cell signal release renal system process involved in regulation of systemic arterial blood pressure lipid localization export from cell regulation of lipid localization macromolecule localization hormone transport positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity regulation of DNA-binding transcription factor activity phospholipase C-activating G protein-coupled receptor signaling pathway muscle hypertrophy regulation of muscle adaptation positive regulation of cardiac muscle hypertrophy striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of multicellular organismal process nitric oxide mediated signal transduction cGMP-mediated signaling nitric oxide-cGMP-mediated signaling developmental process multicellular organism development anatomical structure development animal organ development kidney development renal system development system development G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger plasma lipoprotein particle organization low-density lipoprotein particle remodeling protein-containing complex organization protein-containing complex remodeling protein-lipid complex organization plasma lipoprotein particle remodeling regulation of plasma lipoprotein particle levels protein-lipid complex remodeling positive regulation of locomotion regulation of cell motility endothelial cell migration positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration cell motility locomotion mesonephric epithelium development kidney epithelium development branching morphogenesis of an epithelial tube nephron tubule morphogenesis regulation of kidney development regulation of branching involved in ureteric bud morphogenesis positive regulation of developmental process tube morphogenesis animal organ morphogenesis nephron development regulation of morphogenesis of a branching structure epithelium development regulation of animal organ morphogenesis tissue development mesonephric tubule development renal tubule morphogenesis regulation of developmental process nephron morphogenesis nephron epithelium morphogenesis nephron tubule development ureteric bud morphogenesis positive regulation of morphogenesis of an epithelium branching involved in ureteric bud morphogenesis renal tubule development regulation of morphogenesis of an epithelium epithelial tube morphogenesis regulation of anatomical structure morphogenesis nephron epithelium development ureteric bud development tube development mesonephros development morphogenesis of an epithelium tissue morphogenesis anatomical structure morphogenesis kidney morphogenesis morphogenesis of a branching structure positive regulation of branching involved in ureteric bud morphogenesis mesonephric tubule morphogenesis morphogenesis of a branching epithelium response to muscle activity involved in regulation of muscle adaptation response to activity response to stimulus involved in regulation of muscle adaptation response to muscle activity regulation of epithelial to mesenchymal transition cellular developmental process positive regulation of epithelial to mesenchymal transition regulation of cell differentiation mesenchyme development positive regulation of cell differentiation cell differentiation epithelial to mesenchymal transition mesenchymal cell differentiation positive regulation of extracellular matrix organization extracellular matrix organization regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly regulation of extracellular matrix organization extracellular matrix assembly extracellular structure organization external encapsulating structure organization fibroblast proliferation cell population proliferation positive regulation of cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of apoptotic signaling pathway regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction macrophage derived foam cell differentiation foam cell differentiation regulation of macrophage derived foam cell differentiation positive regulation of macrophage derived foam cell differentiation reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process blood vessel remodeling tissue remodeling maintenance of blood vessel diameter homeostasis by renin-angiotensin renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure cytokine production regulation of cytokine production positive regulation of gene expression positive regulation of cytokine production	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix blood microparticle
B, D	Metalloprotease PmbA	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity	cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex peptidase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR051463	Peptidase U62 metalloprotease	Family
A, C	IPR036059	Metalloprotease TldD/PmbA superfamily	Homologous Superfamily
A, C	IPR045570	Metalloprotease TldD/E, central domain	Domain
A, C	IPR045569	Metalloprotease TldD/E, C-terminal domain	Domain
A, C	IPR002510	Metalloprotease TldD/E, N-terminal domain	Domain
A, C	IPR025502	TldD	Family
A, C	IPR035068	Metalloprotease TldD/PmbA, N-terminal	Homologous Superfamily
E, F	IPR000215	Serpin family	Family
E, F	IPR042178	Serpin superfamily, domain 1	Homologous Superfamily
E, F	IPR023795	Serpin, conserved site	Conserved Site
E, F	IPR033834	Angiotensinogen, serpin domain	Domain
E, F	IPR036186	Serpin superfamily	Homologous Superfamily
E, F	IPR000227	Angiotensinogen	Family
E, F	IPR023796	Serpin domain	Domain
E, F	IPR042185	Serpin superfamily, domain 2	Homologous Superfamily
B, D	IPR002510	Metalloprotease TldD/E, N-terminal domain	Domain
B, D	IPR036059	Metalloprotease TldD/PmbA superfamily	Homologous Superfamily
B, D	IPR035068	Metalloprotease TldD/PmbA, N-terminal	Homologous Superfamily
B, D	IPR045570	Metalloprotease TldD/E, central domain	Domain
B, D	IPR045569	Metalloprotease TldD/E, C-terminal domain	Domain
B, D	IPR047657	Metalloprotease PmbA	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E, F	Pharos: P01019	hypertensive disorder endomyocardial fibrosis IgA glomerulonephritis abdominal aortic aneurysm aortic aneurysm retinopathy of prematurity essential hypertension kidney disease heart disease renal hypertension cardiomyopathy kidney failure glomerulonephritis diabetic retinopathy Hypertrophy hypertensive disorder endomyocardial fibrosis IgA glomerulonephritis abdominal aortic aneurysm aortic aneurysm retinopathy of prematurity essential hypertension kidney disease heart disease renal hypertension cardiomyopathy kidney failure glomerulonephritis diabetic retinopathy Hypertrophy preeclampsia glucose intolerance anemia visual epilepsy renal tubular dysgenesis of genetic origin myocardial infarction cardiovascular disease focal segmental glomerulosclerosis alcoholic cardiomyopathy cirrhosis of liver potassium deficiency disease ureteral obstruction nephrosis carotid artery disease cholestasis pneumonia congestive heart failure proteinuria anuria pulmonary fibrosis malignant hypertension atherosclerosis bipolar disorder esophageal adenocarcinoma pneumonitis ulcerative colitis large cell medulloblastoma psoriasis lung cancer arteriosclerosis disorder malignant pancreatic neoplasm diabetic kidney disease Down syndrome hypotensive disorder subependymal giant cell astrocytoma interstitial cystitis pancreatic ductal adenocarcinoma pituitary cancer congenital diaphragmatic hernia primitive neuroectodermal tumor lung carcinoma depressive disorder atypical teratoid rhabdoid tumor breast cancer myocardial ischemia essential hypertension, genetic idiopathic interstitial pneumonia fetal growth restriction intellectual disability pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia thrombotic disease ischemia reperfusion injury gastric carcinoma lung adenocarcinoma coronary artery disease heart failure renal tubular dysgenesis medulloblastoma