5RZY

EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z219104216

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5rzya2	All alpha proteins	Acyl-CoA binding protein-like	Second domain of FERM	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5rzya3	All beta proteins	PH domain-like barrel	PH domain-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5rzya1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Ubiquitin-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FERM_C	e5rzyA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: FERM_C	ECOD (1.6)
A	FERM_M	e5rzyA2	A: alpha bundles	X: Acyl-CoA binding protein-like (From Topology)	H: Acyl-CoA binding protein-like (From Topology)	T: Acyl-CoA binding protein-like	F: FERM_M	ECOD (1.6)
A	FERM_N	e5rzyA3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: FERM_N	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09379	FERM N-terminal domain (FERM_N)	FERM N-terminal domain	This domain is the N-terminal ubiquitin-like structural domain of the FERM domain.	Domain
A	PF09380	FERM C-terminal PH-like domain (FERM_C)	FERM C-terminal PH-like domain	-	Domain
A	PF00373	FERM central domain (FERM_M)	FERM central domain	This domain is the central structural domain of the FERM domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Isoform 2 of Band 4.1-like protein 3	cytoskeletal protein-membrane anchor activity protein-membrane adaptor activity protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity cytoskeletal protein binding actin binding protein binding binding structural constituent of cytoskeleton structural molecule activity	protein localization localization cellular localization cellular macromolecule localization macromolecule localization protein localization to juxtaparanode region of axon cellular process protein localization to axon apoptotic process cell death programmed cell death protein localization to cell periphery protein localization to plasma membrane localization within membrane protein localization localization cellular localization cellular macromolecule localization macromolecule localization protein localization to juxtaparanode region of axon cellular process protein localization to axon apoptotic process cell death programmed cell death protein localization to cell periphery protein localization to plasma membrane localization within membrane protein localization to membrane cellular component organization organelle organization actomyosin structure organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization multicellular organismal process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development generation of neurons anatomical structure morphogenesis neuron development regulation of biological process regulation of developmental process biological regulation regulation of cell shape regulation of cell morphogenesis regulation of biological quality regulation of anatomical structure morphogenesis cortical cytoskeleton organization membrane organization myelination myelin maintenance axon ensheathment ensheathment of neurons plasma membrane organization endomembrane system organization cortical actin cytoskeleton organization cellular component assembly involved in morphogenesis myelin assembly cellular component biogenesis cellular anatomical entity morphogenesis cellular component assembly cell junction assembly cell-cell junction assembly cell-cell junction organization cell junction organization anatomical structure formation involved in morphogenesis paranodal junction assembly protein localization to paranode region of axon	cell junction cellular anatomical entity axon cell projection main axon juxtaparanode region of axon neuron projection plasma membrane bounded cell projection cell-cell junction anchoring junction paranode region of axon intracellular anatomical structure cytoplasm cytosol cell junction cellular anatomical entity axon cell projection main axon juxtaparanode region of axon neuron projection plasma membrane bounded cell projection cell-cell junction anchoring junction paranode region of axon intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000299	FERM domain	Domain
A	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A	IPR019748	FERM central domain	Domain
A	IPR018980	FERM, C-terminal PH-like domain	Domain
A	IPR000798	Ezrin/radixin/moesin-like	Family
A	IPR008379	Band 4.1, C-terminal	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR014847	FERM adjacent	Domain
A	IPR030691	Band 4.1-like protein 3, FERM domain, F1 sub-domain	Domain
A	IPR019749	Band 4.1 domain	Domain
A	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A	IPR019747	FERM conserved site	Conserved Site
A	IPR018979	FERM, N-terminal	Domain
A	IPR007477	SAB domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y2J2	breast carcinoma malignant mesothelioma Mammary Neoplasms, Human nephrosclerosis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adenoma primitive neuroectodermal tumor astrocytic tumor subependymal giant cell astrocytoma ulcerative colitis diabetes mellitus gastric carcinoma lung adenocarcinoma malignant ependymoma breast carcinoma malignant mesothelioma Mammary Neoplasms, Human nephrosclerosis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adenoma primitive neuroectodermal tumor astrocytic tumor subependymal giant cell astrocytoma ulcerative colitis diabetes mellitus gastric carcinoma lung adenocarcinoma malignant ependymoma medulloblastoma non-small cell lung carcinoma ovarian cancer Pick disease adrenal cortex carcinoma psoriasis atypical teratoid rhabdoid tumor transitional cell carcinoma cerebrovascular disorder Duchenne muscular dystrophy Gaucher disease lung cancer malignant glioma nasopharyngeal carcinoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer amyotrophic lateral sclerosis Sjogren syndrome breast cancer tuberculosis cystic fibrosis facioscapulohumeral muscular dystrophy glioblastoma malignant colon neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.