5T46

Crystal structure of the human eIF4E-eIF4G complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d5t46c_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	Translation initiation factor eIF4e	Translation initiation factor eIF4e	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5t46a_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	Translation initiation factor eIF4e	Translation initiation factor eIF4e	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	eIF4e-like	8037387	3001871	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	eIF4e-like	8037387	3001871	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	IF4E	e5t46C1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: IF4E	ECOD (1.6)
A	IF4E	e5t46A1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: IF4E	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
A	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF01652	Eukaryotic initiation factor 4E (IF4E)	Eukaryotic initiation factor 4E	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Eukaryotic translation initiation factor 4E	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding translation initiation factor binding eukaryotic initiation factor 4G binding RNA binding mRNA cap binding RNA cap binding mRNA binding translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding translation initiation factor binding eukaryotic initiation factor 4G binding RNA binding mRNA cap binding RNA cap binding mRNA binding RNA 7-methylguanosine cap binding transcription factor binding DNA-binding transcription factor binding enzyme binding	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation biosynthetic process translational initiation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of protein metabolic process negative regulation of metabolic process regulation of macromolecule metabolic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process modulation of chemical synaptic transmission signaling regulation of translation at synapse, modulating synaptic transmission cell communication synaptic signaling postsynaptic modulation of chemical synaptic transmission trans-synaptic signaling regulation of signaling cell-cell signaling regulation of translation at postsynapse regulation of translation at synapse chemical synaptic transmission regulation of translation at postsynapse, modulating synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization cellular response to stimulus response to ketone response to lipid response to stimulus cellular response to endogenous stimulus response to hormone response to steroid hormone cellular response to ketone cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus response to endogenous stimulus cellular response to dexamethasone stimulus response to glucocorticoid cellular response to organic cyclic compound cellular response to glucocorticoid stimulus response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to corticosteroid stimulus response to corticosteroid cellular response to chemical stimulus response to chemical cellular response to lipid response to dexamethasone maintenance of cell number stem cell population maintenance mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process behavioral defense response behavior fear response behavioral fear response defense response response to stress multicellular organismal response to stress positive regulation of biological process positive regulation of cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle regulation of cell cycle positive regulation of cellular process	protein-containing complex ribonucleoprotein complex RNAi effector complex RISC complex intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex protein-containing complex ribonucleoprotein complex RNAi effector complex RISC complex intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol chromatoid body synapse cell junction glutamatergic synapse perinuclear region of cytoplasm P-body eukaryotic translation initiation factor 4F complex RNA cap binding complex intracellular protein-containing complex postsynapse
B, D	Eukaryotic translation initiation factor 4 gamma 1	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding eukaryotic initiation factor 4E binding protein binding translation initiation factor binding RNA binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding eukaryotic initiation factor 4E binding protein binding translation initiation factor binding RNA binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding mRNA binding molecular adaptor activity	regulation of biological process regulation of growth regulation of cellular process regulation of cellular component organization positive regulation of biological process biological regulation growth positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular process cellular component organization or biogenesis regulation of biological process regulation of growth regulation of cellular process regulation of cellular component organization positive regulation of biological process biological regulation growth positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular process cellular component organization or biogenesis positive regulation of cellular process biosynthetic process translational initiation metabolic process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process positive regulation of protein metabolic process regulation of protein metabolic process regulation of macromolecule metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of metabolic process positive regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis eukaryotic translation initiation factor 4F complex assembly regulation of cellular component biogenesis regulation of eukaryotic translation initiation factor 4F complex assembly cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly positive regulation of eukaryotic translation initiation factor 4F complex assembly protein-containing complex assembly cellular response to stimulus response to stimulus positive regulation of translation positive regulation of macromolecule biosynthetic process post-transcriptional regulation of gene expression regulation of translation in response to stress cellular response to stress positive regulation of biosynthetic process response to stress positive regulation of translation in response to stress response to endoplasmic reticulum stress positive regulation of translation in response to endoplasmic reticulum stress regulation of biosynthetic process regulation of translation in response to endoplasmic reticulum stress regulation of gene expression positive regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process regulation of peptidyl-threonine phosphorylation negative regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process peptidyl-amino acid modification peptidyl-threonine modification protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process protein phosphorylation phosphorylation negative regulation of metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of peptidyl-threonine phosphorylation negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation peptidyl-threonine phosphorylation cap-dependent translational initiation cytoplasmic translation cytoplasmic translational initiation cellular response to nutrient levels response to nutrient levels multicellular organismal process regulation of presynapse assembly multicellular organism development regulation of presynapse organization cell junction assembly anatomical structure development regulation of synapse structure or activity synapse organization regulation of biological quality regulation of synapse assembly system development developmental process presynapse organization nervous system development regulation of cell junction assembly regulation of synapse organization cell junction organization synapse assembly presynapse assembly tube development animal organ development respiratory tube development lung development respiratory system development multicellular organismal-level homeostasis homeostatic process energy homeostasis positive regulation of RNA binding positive regulation of mRNA cap binding regulation of binding regulation of mRNA binding positive regulation of binding regulation of RNA binding positive regulation of mRNA binding regulation of molecular function positive regulation of molecular function regulation of mRNA cap binding positive regulation of phosphorylation regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification positive regulation of protein modification process peptidyl-serine phosphorylation positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of peptidyl-serine phosphorylation negative regulation of translation miRNA-mediated gene silencing by inhibition of translation regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA-mediated gene silencing miRNA-mediated post-transcriptional gene silencing negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process post-transcriptional gene silencing positive regulation of protein localization to cell periphery protein localization regulation of localization cellular localization protein localization to cell periphery regulation of protein localization regulation of protein localization to cell periphery localization regulation of cellular localization cellular macromolecule localization macromolecule localization positive regulation of protein localization regulation of cellular response to stress regulation of response to stimulus regulation of response to stress cellular developmental process generation of neurons neurogenesis neuron differentiation cell differentiation regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition response to alcohol response to chemical response to oxygen-containing compound response to ethanol regulation of developmental process regulation of cell differentiation positive regulation of neuron differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of neuron differentiation regulation of translational initiation negative regulation of catabolic process catabolic process autophagy regulation of catabolic process regulation of autophagy negative regulation of autophagy process utilizing autophagic mechanism behavioral defense response behavior fear response behavioral fear response defense response multicellular organismal response to stress	intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule membrane cytosol ribosome intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule membrane cytosol ribosome protein-containing complex eukaryotic translation initiation factor 4F complex RNA cap binding complex intracellular protein-containing complex postsynapse synapse cell junction membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR023398	Translation Initiation factor eIF- 4e-like	Homologous Superfamily
A, C	IPR019770	Eukaryotic translation initiation factor 4E (eIF-4E), conserved site	Conserved Site
A, C	IPR001040	Translation Initiation factor eIF- 4e	Family
B, D	IPR016024	Armadillo-type fold	Homologous Superfamily
B, D	IPR003307	W2 domain	Domain
B, D	IPR003891	Initiation factor eIF-4 gamma, MA3	Domain
B, D	IPR045208	IF4G	Unknown
B, D	IPR003890	MIF4G-like, type 3	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: P06730	Neoplasm Invasiveness mantle cell lymphoma ovarian cancer primitive neuroectodermal tumor tuberculosis astrocytic tumor autism spectrum disorder cancer large cell medulloblastoma lymphangioma malignant ependymoma oligodendroglioma pilocytic astrocytoma renal cell carcinoma tuberous sclerosis Neoplasm Invasiveness mantle cell lymphoma ovarian cancer primitive neuroectodermal tumor tuberculosis astrocytic tumor autism spectrum disorder cancer large cell medulloblastoma lymphangioma malignant ependymoma oligodendroglioma pilocytic astrocytoma renal cell carcinoma tuberous sclerosis atypical teratoid rhabdoid tumor autism, susceptibility to, 19 disappearing bone disease lung lymphangioleiomyomatosis malignant glioma medulloblastoma osteosarcoma subependymal giant cell astrocytoma autism glioblastoma
B, D	Pharos: Q04637	Parkinson disease 18, autosomal dominant, susceptibility to Parkinson disease adenoma Autosomal dominant late onset Parkinson disease glioblastoma neurodegenerative disease amyotrophic lateral sclerosis colorectal cancer intellectual disability non-small cell lung carcinoma astrocytic tumor gastric carcinoma large cell medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.