5T47
Crystal structure of the D. melanogaster eIF4E-eIF4G complex
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d5t47a1 | Alpha and beta proteins (a+b) | eIF4e-like | eIF4e-like | automated matches | automated matches | Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ], | SCOPe (2.08) |
A | d5t47a2 | Artifacts | Tags | Tags | Tags | N-terminal Tags | Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ], | SCOPe (2.08) |
C | d5t47c1 | Alpha and beta proteins (a+b) | eIF4e-like | eIF4e-like | automated matches | automated matches | Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ], | SCOPe (2.08) |
C | d5t47c2 | Artifacts | Tags | Tags | Tags | N-terminal Tags | Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | IF4E | e5t47A1 | A: a+b two layers | X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology) | H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology) | T: Translation initiation factor eIF4e and phosphothreonine lyase | F: IF4E | ECOD (1.6) |
C | IF4E | e5t47C1 | A: a+b two layers | X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology) | H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology) | T: Translation initiation factor eIF4e and phosphothreonine lyase | F: IF4E | ECOD (1.6) |
B | eIF_4G1_like | e5t47B1 | A: alpha arrays | X: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain (From Topology) | H: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain (From Topology) | T: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain | F: eIF_4G1_like | ECOD (1.6) |
D | eIF_4G1_like | e5t47D1 | A: alpha arrays | X: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain (From Topology) | H: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain (From Topology) | T: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain | F: eIF_4G1_like | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.30.760.10 | Alpha Beta | 2-Layer Sandwich | RNA Cap, Translation Initiation Factor Eif4e | RNA Cap, Translation Initiation Factor Eif4e | CATH (4.3.0) |
C | 3.30.760.10 | Alpha Beta | 2-Layer Sandwich | RNA Cap, Translation Initiation Factor Eif4e | RNA Cap, Translation Initiation Factor Eif4e | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF01652 | Eukaryotic initiation factor 4E (IF4E) | Eukaryotic initiation factor 4E | - | Domain | |
PF21140 | Translation initiation factor eIF4G-like, eIF4E-binding domain (eIF4G1-like_eIF4E-bd) | Translation initiation factor eIF4G-like, eIF4E-binding domain | This domain is found in proteins from animals, including Translation initiation factor eIF4G (eIF4G1) from Drosophila melanogaster. This domain shows a canonical helix, a linker and an elbow loop. It shows a conserved sequence YXR/KXXLXXXR/K/Q that p ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR019770 | Eukaryotic translation initiation factor 4E (eIF-4E), conserved site | Conserved Site | |
IPR023398 | Translation Initiation factor eIF- 4e-like | Homologous Superfamily | |
IPR001040 | Translation Initiation factor eIF- 4e | Family | |
IPR016024 | Armadillo-type fold | Homologous Superfamily | |
IPR003307 | W2 domain | Domain | |
IPR003891 | Initiation factor eIF-4 gamma, MA3 | Domain | |
IPR003890 | MIF4G-like, type 3 | Domain | |
IPR045208 | IF4G | Unknown | |
IPR049485 | Translation initiation factor eIF4G-like, eIF4E-binding domain | Domain |