5TXN
STRUCTURE OF Q151M MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | RVT_thumb | e5txnA2 | A: alpha bundles | X: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | H: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | T: helical bundle domain in reverse transcriptase-like polymerases | F: RVT_thumb | ECOD (1.6) |
A | RVT_1 | e5txnA1 | A: a+b two layers | X: Alpha-beta plaits | H: Adenylyl and guanylyl cyclase catalytic domain-like | T: Adenylyl and guanylyl cyclase catalytic domain-like | F: RVT_1 | ECOD (1.6) |
A | RNase_H | e5txnA3 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: RNase_H | ECOD (1.6) |
A | RVT_connect | e5txnA4 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: RNaseH-like domain in reverse transcriptase (From Topology) | T: RNaseH-like domain in reverse transcriptase | F: RVT_connect | ECOD (1.6) |
E [auth C] | RVT_thumb | e5txnC4 | A: alpha bundles | X: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | H: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | T: helical bundle domain in reverse transcriptase-like polymerases | F: RVT_thumb | ECOD (1.6) |
E [auth C] | RVT_1 | e5txnC3 | A: a+b two layers | X: Alpha-beta plaits | H: Adenylyl and guanylyl cyclase catalytic domain-like | T: Adenylyl and guanylyl cyclase catalytic domain-like | F: RVT_1 | ECOD (1.6) |
E [auth C] | RNase_H | e5txnC1 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: RNase_H | ECOD (1.6) |
E [auth C] | RVT_connect | e5txnC2 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: RNaseH-like domain in reverse transcriptase (From Topology) | T: RNaseH-like domain in reverse transcriptase | F: RVT_connect | ECOD (1.6) |
B | RVT_thumb | e5txnB1 | A: alpha bundles | X: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | H: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | T: helical bundle domain in reverse transcriptase-like polymerases | F: RVT_thumb | ECOD (1.6) |
B | RVT_1 | e5txnB3 | A: a+b two layers | X: Alpha-beta plaits | H: Adenylyl and guanylyl cyclase catalytic domain-like | T: Adenylyl and guanylyl cyclase catalytic domain-like | F: RVT_1 | ECOD (1.6) |
B | RVT_connect | e5txnB2 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: RNaseH-like domain in reverse transcriptase (From Topology) | T: RNaseH-like domain in reverse transcriptase | F: RVT_connect | ECOD (1.6) |
F [auth D] | RVT_thumb | e5txnD3 | A: alpha bundles | X: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | H: helical bundle domain in reverse transcriptase-like polymerases (From Topology) | T: helical bundle domain in reverse transcriptase-like polymerases | F: RVT_thumb | ECOD (1.6) |
F [auth D] | RVT_1 | e5txnD1 | A: a+b two layers | X: Alpha-beta plaits | H: Adenylyl and guanylyl cyclase catalytic domain-like | T: Adenylyl and guanylyl cyclase catalytic domain-like | F: RVT_1 | ECOD (1.6) |
F [auth D] | RVT_connect | e5txnD2 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: RNaseH-like domain in reverse transcriptase (From Topology) | T: RNaseH-like domain in reverse transcriptase | F: RVT_connect | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, E [auth C] | PF06817 | Reverse transcriptase thumb domain (RVT_thumb) | Reverse transcriptase thumb domain | This domain is known as the thumb domain. It is composed of a four helix bundle [1]. | Domain |
A, E [auth C] | PF06815 | Reverse transcriptase connection domain (RVT_connect) | Reverse transcriptase connection domain | This domain is known as the connection domain. This domain lies between the thumb and palm domains [1]. | Domain |
A, E [auth C] | PF00075 | RNase H (RNase_H) | RNase H | RNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers. | Domain |
A, E [auth C] | PF00078 | Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1) | Reverse transcriptase (RNA-dependent DNA polymerase) | A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ... | Domain |
B, F [auth D] | PF06817 | Reverse transcriptase thumb domain (RVT_thumb) | Reverse transcriptase thumb domain | This domain is known as the thumb domain. It is composed of a four helix bundle [1]. | Domain |
B, F [auth D] | PF06815 | Reverse transcriptase connection domain (RVT_connect) | Reverse transcriptase connection domain | This domain is known as the connection domain. This domain lies between the thumb and palm domains [1]. | Domain |
B, F [auth D] | PF00078 | Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1) | Reverse transcriptase (RNA-dependent DNA polymerase) | A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ... | Domain |