Annotations: 5UI2

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5ui2a1	All alpha proteins	Orange carotenoid protein, N-terminal domain	Orange carotenoid protein, N-terminal domain	Orange carotenoid protein, N-terminal domain	Orange carotenoid protein, N-terminal domain	(Limnospira maxima ) [TaxId: 129910 ],	SCOPe (2.08)
A	d5ui2a2	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Orange carotenoid protein, C-terminal domain	Orange carotenoid protein, C-terminal domain	(Limnospira maxima ) [TaxId: 129910 ],	SCOPe (2.08)
B	d5ui2b1	All alpha proteins	Orange carotenoid protein, N-terminal domain	Orange carotenoid protein, N-terminal domain	Orange carotenoid protein, N-terminal domain	Orange carotenoid protein, N-terminal domain	(Limnospira maxima ) [TaxId: 129910 ],	SCOPe (2.08)
B	d5ui2b2	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Orange carotenoid protein, C-terminal domain	Orange carotenoid protein, C-terminal domain	(Limnospira maxima ) [TaxId: 129910 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Orange carotenoid protein, N-terminal domain	8031020	4002541	SCOP2 (2022-06-29)
A	SCOP2 Family	Orange carotenoid protein, C-terminal domain	8031021	4003185	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Orange carotenoid protein, N-terminal domain	8043398	3001394	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	NTF2-like	8043399	3000472	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	NTF2-like	8043399	3000472	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Orange carotenoid protein, N-terminal domain	8043398	3001394	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Carot_N	e5ui2A1	A: alpha arrays	X: Orange carotenoid protein, N-terminal domain (From Topology)	H: Orange carotenoid protein, N-terminal domain (From Topology)	T: Orange carotenoid protein, N-terminal domain	F: Carot_N	ECOD (1.6)
A	NTF2	e5ui2A2	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: NTF2	ECOD (1.6)
B	Carot_N	e5ui2B2	A: alpha arrays	X: Orange carotenoid protein, N-terminal domain (From Topology)	H: Orange carotenoid protein, N-terminal domain (From Topology)	T: Orange carotenoid protein, N-terminal domain	F: Carot_N	ECOD (1.6)
B	NTF2	e5ui2B1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: NTF2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.2090.10	Mainly Alpha	Orthogonal Bundle	orange carotenoid protein, domain 2	Orange carotenoid-binding protein, N-terminal domain	CATH (4.3.0)
A	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
B	1.10.2090.10	Mainly Alpha	Orthogonal Bundle	orange carotenoid protein, domain 2	Orange carotenoid-binding protein, N-terminal domain	CATH (4.3.0)
B	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF09150	Orange carotenoid protein, N-terminal (Carot_N)	Orange carotenoid protein, N-terminal	Members of this family adopt an alpha-helical structure consisting of two four-helix bundles. They are predominantly found in prokaryotic orange carotenoid protein, and carotenoid binding proteins [1].	Domain
A, B	PF02136	Nuclear transport factor 2 (NTF2) domain (NTF2)	Nuclear transport factor 2 (NTF2) domain	This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Orange carotenoid-binding protein	molecular transducer activity photoreceptor activity signaling receptor activity ion binding binding anion binding chloride ion binding small molecule binding	detection of light stimulus response to light stimulus detection of external stimulus response to stimulus response to external stimulus detection of abiotic stimulus detection of stimulus light absorption response to abiotic stimulus response to radiation cellular process	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane intracellular membraneless organelle plasma membrane-derived chromatophore thylakoid membrane intracellular organelle cell periphery cellular anatomical structure plasma membrane-derived thylakoid membrane organelle membraneless organelle plasma membrane region intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane intracellular membraneless organelle plasma membrane-derived chromatophore thylakoid membrane intracellular organelle cell periphery cellular anatomical structure plasma membrane-derived thylakoid membrane organelle membraneless organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid protein-containing complex membrane protein complex light-harvesting complex phycobilisome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR015233	Orange carotenoid-binding protein, N-terminal	Domain
A, B	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A, B	IPR002075	Nuclear transport factor 2 domain	Domain
A, B	IPR036917	Orange carotenoid-binding protein, N-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.