5V7I

Crystal structure of homo sapiens serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), in complex with glycine, PLP and folate-competitive pyrazolopyran inhibitor: 6-amino-4-isopropyl-3-methyl-4-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyPLP-dependent transferases 8036728 3000954 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPLP-dependent transferases 8036728 3000954 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ASHMTe5v7iA1 A: a+b two layersX: C-terminal domain in some PLP-dependent transferases (From Topology)H: C-terminal domain in some PLP-dependent transferases (From Topology)T: C-terminal domain in some PLP-dependent transferasesF: SHMTECOD (1.6)
AAminotran_5_Ne5v7iA2 A: a/b three-layered sandwichesX: PLP-dependent transferases (From Topology)H: PLP-dependent transferases (From Topology)T: PLP-dependent transferasesF: Aminotran_5_NECOD (1.6)
BSHMTe5v7iB1 A: a+b two layersX: C-terminal domain in some PLP-dependent transferases (From Topology)H: C-terminal domain in some PLP-dependent transferases (From Topology)T: C-terminal domain in some PLP-dependent transferasesF: SHMTECOD (1.6)
BAminotran_5_Ne5v7iB2 A: a/b three-layered sandwichesX: PLP-dependent transferases (From Topology)H: PLP-dependent transferases (From Topology)T: PLP-dependent transferasesF: Aminotran_5_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00464Serine hydroxymethyltransferase (SHMT)Serine hydroxymethyltransferase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Serine hydroxymethyltransferase, mitochondrial

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A, B
LLP Parent Component: LYS

RESIDAA0119

PSI-MOD :  N6-pyridoxal phosphate-L-lysine MOD:00128