5X03

Crystal structure of the C-terminal domain of Bacillus subtilis GabR reveals a closed conformation by the binding of gamma-aminobutyric acid, inducing the transcriptional activation

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aminotran_1_2_C_11	e5x03A2	A: a+b two layers	X: C-terminal domain in some PLP-dependent transferases (From Topology)	H: C-terminal domain in some PLP-dependent transferases (From Topology)	T: C-terminal domain in some PLP-dependent transferases	F: Aminotran_1_2_C_11	ECOD (1.6)
A	Aminotran_1_2_N	e5x03A1	A: a/b three-layered sandwiches	X: PLP-dependent transferases (From Topology)	H: PLP-dependent transferases (From Topology)	T: PLP-dependent transferases	F: Aminotran_1_2_N	ECOD (1.6)
B	Aminotran_1_2_C_11	e5x03B2	A: a+b two layers	X: C-terminal domain in some PLP-dependent transferases (From Topology)	H: C-terminal domain in some PLP-dependent transferases (From Topology)	T: C-terminal domain in some PLP-dependent transferases	F: Aminotran_1_2_C_11	ECOD (1.6)
B	Aminotran_1_2_N	e5x03B1	A: a/b three-layered sandwiches	X: PLP-dependent transferases (From Topology)	H: PLP-dependent transferases (From Topology)	T: PLP-dependent transferases	F: Aminotran_1_2_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.640.10	Alpha Beta	3-Layer(aba) Sandwich	Aspartate Aminotransferase	domain 2	CATH (4.3.0)
B	3.40.640.10	Alpha Beta	3-Layer(aba) Sandwich	Aspartate Aminotransferase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00155	Aminotransferase class I and II (Aminotran_1_2)	Aminotransferase class I and II	-	Domain
B	PF00155	Aminotransferase class I and II (Aminotran_1_2)	Aminotransferase class I and II	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	HTH-type transcriptional regulatory protein GabR	DNA binding binding organic cyclic compound binding nucleic acid binding transferase activity, transferring nitrogenous groups transaminase activity transferase activity catalytic activity transcription regulator activity DNA-binding transcription factor activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding DNA binding binding organic cyclic compound binding nucleic acid binding transferase activity, transferring nitrogenous groups transaminase activity transferase activity catalytic activity transcription regulator activity DNA-binding transcription factor activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding anion binding heterocyclic compound binding small molecule binding	biosynthetic process metabolic process	-
B	HTH-type transcriptional regulatory protein GabR	DNA binding binding organic cyclic compound binding nucleic acid binding transferase activity, transferring nitrogenous groups transaminase activity transferase activity catalytic activity transcription regulator activity DNA-binding transcription factor activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding DNA binding binding organic cyclic compound binding nucleic acid binding transferase activity, transferring nitrogenous groups transaminase activity transferase activity catalytic activity transcription regulator activity DNA-binding transcription factor activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding anion binding heterocyclic compound binding small molecule binding	biosynthetic process metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015424	Pyridoxal phosphate-dependent transferase	Homologous Superfamily
A	IPR015421	Pyridoxal phosphate-dependent transferase, major domain	Homologous Superfamily
A	IPR051446	HTH-type transcriptional regulator with aminotransferase domain	Family
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR000524	Transcription regulator HTH, GntR	Domain
A	IPR004839	Aminotransferase, class I/classII, large domain	Domain
A	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
B	IPR015424	Pyridoxal phosphate-dependent transferase	Homologous Superfamily
B	IPR015421	Pyridoxal phosphate-dependent transferase, major domain	Homologous Superfamily
B	IPR051446	HTH-type transcriptional regulator with aminotransferase domain	Family
B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
B	IPR000524	Transcription regulator HTH, GntR	Domain
B	IPR004839	Aminotransferase, class I/classII, large domain	Domain
B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.