Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ATransketolase_C_1e5xqaA2 A: a/b three-layered sandwichesX: TK C-terminal domain-like (From Topology)H: TK C-terminal domain-like (From Topology)T: TK C-terminal domain-likeF: Transketolase_C_1ECOD (1.6)
ATransketolase_Ne5xqaA3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: Transketolase_NECOD (1.6)
ATransket_pyre5xqaA1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: Transket_pyrECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.970 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domainsCATH (4.3.0)
A3.40.50.920 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF02779Transketolase, pyrimidine binding domain (Transket_pyr)Transketolase, pyrimidine binding domainThis family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.Domain
PF22613Transketolase-like TK C-terminal domain (Transketolase_C_1)Transketolase-like TK C-terminal domainThis entry represents the C-terminal domain found in transketolase and transketolase-like enzymes [1-5], such as pyruvate dehydrogenase E1 component (OPD1) [4].Domain
PF00456Transketolase, thiamine diphosphate binding domain (Transketolase_N)Transketolase, thiamine diphosphate binding domainThis family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4. Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common ...This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4. Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Transketolase