5YAK

The crystal structure of human IYD Thr239 mutant with ligand 3-Fluorotyrosine (F-Tyr)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8086289	3001947	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8086289	3001947	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8086289	3001947	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8086289	3001947	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8086289	3001947	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	FMN-dependent nitroreductase-like	8086289	3001947	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Nitroreductase	e5yakA1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
C	Nitroreductase	e5yakC1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
D	Nitroreductase	e5yakD1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
E	Nitroreductase	e5yakE1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
F	Nitroreductase	e5yakF1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)
B	Nitroreductase	e5yakB1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: Nitroreductase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
C	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
D	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
E	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
F	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)
B	3.40.109.10	Alpha Beta	3-Layer(aba) Sandwich	NADH Oxidase	NADH Oxidase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00881	Nitroreductase family (Nitroreductase)	Nitroreductase family	The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Iodotyrosine deiodinase 1	oxidoreductase activity catalytic activity oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond iodotyrosine deiodinase activity binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding oxidoreductase activity catalytic activity oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond iodotyrosine deiodinase activity binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	regulation of hormone levels phenol-containing compound metabolic process organic hydroxy compound metabolic process biological regulation modified amino acid metabolic process metabolic process cellular process regulation of biological quality hormone metabolic process thyroid hormone metabolic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process aromatic amino acid metabolic process oxoacid metabolic process carboxylic acid metabolic process regulation of hormone levels phenol-containing compound metabolic process organic hydroxy compound metabolic process biological regulation modified amino acid metabolic process metabolic process cellular process regulation of biological quality hormone metabolic process thyroid hormone metabolic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process aromatic amino acid metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process small molecule metabolic process tyrosine metabolic process	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane cell periphery plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR050627	Nitroreductase/BluB	Family
A, B, C, D, E A, B, C, D, E, F	IPR029479	Nitroreductase	Domain
A, B, C, D, E A, B, C, D, E, F	IPR000415	Nitroreductase-like	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q6PHW0	congenital hypothyroidism thyroid dyshormonogenesis 4 Liver Cirrhosis, Experimental hypothyroidism pancreatic intraductal papillary-mucinous neoplasm familial thyroid dyshormonogenesis psoriasis familial thyroid dyshormonogenesis 1 pancreatic intraductal papillary-mucinous carcinoma Sjogren syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.