Annotations: 5YH2

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fam20C	e5yh2A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Fam20C	ECOD (1.6)
C [auth B]	Fam20C	e5yh2B1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Fam20C	ECOD (1.6)
B [auth C]	Fam20C	e5yh2C1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Fam20C	ECOD (1.6)
D	Fam20C	e5yh2D1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Fam20C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF06702	Golgi casein kinase, C-terminal, Fam20 (Fam20C)	Golgi casein kinase, C-terminal, Fam20	-	Family
B [auth C], D	PF06702	Golgi casein kinase, C-terminal, Fam20 (Fam20C)	Golgi casein kinase, C-terminal, Fam20	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	Pseudokinase FAM20A	enzyme regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity	inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus developmental process inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus developmental process enamel mineralization tooth mineralization odontogenesis of dentin-containing tooth odontogenesis animal organ development amelogenesis tissue development anatomical structure morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis animal organ morphogenesis biomineral tissue development regulation of cellular process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process regulation of biological process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification regulation of phosphorus metabolic process metabolic process cellular process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process tooth eruption	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle endoplasmic reticulum
B [auth C], D	Family with sequence similarity 20, member Ca	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding metal ion binding	developmental process enamel mineralization tooth mineralization odontogenesis of dentin-containing tooth odontogenesis animal organ development amelogenesis tissue development anatomical structure morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis animal organ morphogenesis biomineral tissue development	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR024869	FAM20	Family
A, C [auth B]	IPR009581	FAM20, C-terminal	Domain
B [auth C], D	IPR024869	FAM20	Family
B [auth C], D	IPR009581	FAM20, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth B]	Pharos: Q96MK3	amelogenesis imperfecta amelogenesis imperfecta type 1G juvenile idiopathic arthritis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis amelogenesis imperfecta-gingival hyperplasia syndrome exocrine pancreatic carcinoma intellectual disability Juvenile arthritis malignant pancreatic neoplasm ovarian cancer pituitary cancer breast cancer head and neck cancer amelogenesis imperfecta amelogenesis imperfecta type 1G juvenile idiopathic arthritis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis amelogenesis imperfecta-gingival hyperplasia syndrome exocrine pancreatic carcinoma intellectual disability Juvenile arthritis malignant pancreatic neoplasm ovarian cancer pituitary cancer breast cancer head and neck cancer interstitial cystitis large cell medulloblastoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma chronic obstructive pulmonary disease heart disease invasive ductal breast carcinoma lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.