Annotations: 5YH3

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fam20C	e5yh3A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Fam20C	ECOD (1.6)
C [auth B]	Fam20C	e5yh3B1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Fam20C	ECOD (1.6)
B [auth C]	Fam20C	e5yh3C1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Fam20C	ECOD (1.6)
D	Fam20C	e5yh3D1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Fam20C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF06702	Golgi casein kinase, C-terminal, Fam20 (Fam20C)	Golgi casein kinase, C-terminal, Fam20	-	Family
B [auth C], D	PF06702	Golgi casein kinase, C-terminal, Fam20 (Fam20C)	Golgi casein kinase, C-terminal, Fam20	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	Pseudokinase FAM20A	enzyme regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity	inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus developmental process inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus developmental process enamel mineralization tooth mineralization odontogenesis of dentin-containing tooth odontogenesis animal organ development amelogenesis tissue development anatomical structure morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis animal organ morphogenesis biomineral tissue development regulation of cellular process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process regulation of biological process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification regulation of phosphorus metabolic process metabolic process cellular process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process tooth eruption	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle endoplasmic reticulum
B [auth C], D	Extracellular serine/threonine protein kinase FAM20C	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding manganese ion binding transition metal ion binding protein binding enzyme binding protease binding catalytic activity, acting on a protein kinase activity protein kinase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding manganese ion binding transition metal ion binding protein binding enzyme binding protease binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding protein serine/threonine kinase activity	response to fibroblast growth factor cellular response to stimulus cellular response to growth factor stimulus regulation of cellular process response to stimulus signaling regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of biological process regulation of signaling response to fibroblast growth factor cellular response to stimulus cellular response to growth factor stimulus regulation of cellular process response to stimulus signaling regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus biological regulation regulation of response to stimulus fibroblast growth factor receptor signaling pathway regulation of cell communication cellular process response to growth factor cellular response to fibroblast growth factor stimulus regulation of fibroblast growth factor receptor signaling pathway cellular metabolic process regulation of phosphorus metabolic process metabolic process regulation of cellular metabolic process phosphorus metabolic process regulation of metabolic process developmental process enamel mineralization tooth mineralization odontogenesis of dentin-containing tooth odontogenesis animal organ development amelogenesis tissue development anatomical structure morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis animal organ morphogenesis biomineral tissue development multicellular organismal process regulation of developmental process positive regulation of biological process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process multicellular organism development positive regulation of biomineral tissue development ossification regulation of multicellular organismal process regulation of multicellular organismal development bone mineralization positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification macromolecule modification primary metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process dentinogenesis protein phosphorylation phosphorylation phosphate-containing compound metabolic process regulation of osteoblast differentiation cellular developmental process regulation of cell differentiation osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of cell differentiation cell differentiation positive regulation of cellular process myeloid leukocyte differentiation cell development skeletal system development osteoclast differentiation bone cell development cell maturation bone development system development hemopoiesis developmental maturation osteoclast development osteoclast maturation myeloid cell differentiation anatomical structure maturation myeloid cell development leukocyte differentiation epithelium development epithelial cell differentiation neuroepithelial cell differentiation odontoblast differentiation columnar/cuboidal epithelial cell differentiation	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen Golgi apparatus cytoplasm endomembrane system endoplasmic reticulum lumen endoplasmic reticulum Golgi membrane membrane bounding membrane of organelle organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR024869	FAM20	Family
A, C [auth B]	IPR009581	FAM20, C-terminal	Domain
B [auth C], D	IPR024869	FAM20	Family
B [auth C], D	IPR009581	FAM20, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth B]	Pharos: Q96MK3	amelogenesis imperfecta amelogenesis imperfecta type 1G juvenile idiopathic arthritis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis amelogenesis imperfecta-gingival hyperplasia syndrome exocrine pancreatic carcinoma intellectual disability Juvenile arthritis malignant pancreatic neoplasm ovarian cancer pituitary cancer breast cancer head and neck cancer amelogenesis imperfecta amelogenesis imperfecta type 1G juvenile idiopathic arthritis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis amelogenesis imperfecta-gingival hyperplasia syndrome exocrine pancreatic carcinoma intellectual disability Juvenile arthritis malignant pancreatic neoplasm ovarian cancer pituitary cancer breast cancer head and neck cancer interstitial cystitis large cell medulloblastoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma chronic obstructive pulmonary disease heart disease invasive ductal breast carcinoma lung carcinoma
B [auth C], D	Pharos: Q8IXL6	lethal osteosclerotic bone dysplasia ulcerative colitis amelogenesis imperfecta breast cancer cystic fibrosis intellectual disability malignant glioma osteogenesis imperfecta pilocytic astrocytoma arthrogryposis choanal atresia glioblastoma interstitial cystitis malignant pancreatic neoplasm ovarian cancer lethal osteosclerotic bone dysplasia ulcerative colitis amelogenesis imperfecta breast cancer cystic fibrosis intellectual disability malignant glioma osteogenesis imperfecta pilocytic astrocytoma arthrogryposis choanal atresia glioblastoma interstitial cystitis malignant pancreatic neoplasm ovarian cancer rickets brain glioma craniosynostosis hydrocephalus medulloblastoma pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.