Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNuclear receptor ligand-binding domain 8039119 3001442 SCOP2B (2022-06-29)
C [auth H]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8039119 3001442 SCOP2B (2022-06-29)
B [auth D]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038695 3001442 SCOP2B (2022-06-29)
D [auth L]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038695 3001442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHormone_recep_1e6a5zA1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recep_1ECOD (1.6)
C [auth H]Hormone_recep_1e6a5zH1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recep_1ECOD (1.6)
B [auth D]Hormone_recepe6a5zD1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
D [auth L]Hormone_recepe6a5zL1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
C [auth H]
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
C [auth H]
Bile acid receptor
B [auth D],
D [auth L]
Retinoic acid receptor RXR-alpha
E,
F,
G,
H [auth I]
Nuclear receptor coactivator 1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A,
C [auth H]
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
A,
C [auth H]
IPR001728Thyroid hormone receptorFamily
A,
C [auth H]
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
A,
C [auth H]
IPR044114Bile acid receptor, ligand binding domainDomain
A,
C [auth H]
IPR050234Nuclear hormone receptor family NR1 subfamilyFamily
A,
C [auth H]
IPR001723Nuclear hormone receptorFamily
A,
C [auth H]
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
A,
C [auth H]
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
B [auth D],
D [auth L]
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
B [auth D],
D [auth L]
IPR021780Nuclear/hormone receptor activator site AF-1Domain
B [auth D],
D [auth L]
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
B [auth D],
D [auth L]
IPR000003Retinoid X receptor/HNF4Family
B [auth D],
D [auth L]
IPR050274Nuclear hormone receptor family NR2 subfamilyFamily
B [auth D],
D [auth L]
IPR001723Nuclear hormone receptorFamily
B [auth D],
D [auth L]
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
B [auth D],
D [auth L]
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
E,
F,
G,
H [auth I]
IPR010011Nuclear receptor coactivator, DUF1518Domain
E,
F,
G,
H [auth I]
IPR028819Nuclear receptor coactivator 1, basic helix-loop-helixDomain
E,
F,
G,
H [auth I]
IPR009110Nuclear receptor coactivator, interlockingHomologous Superfamily
E,
F,
G,
H [auth I]
IPR017426Nuclear receptor coactivatorFamily
E,
F,
G,
H [auth I]
IPR014935Nuclear receptor coactivator, receptor-binding domainDomain
E,
F,
G,
H [auth I]
IPR014920Nuclear receptor coactivator, Ncoa-type, interlockingDomain
E,
F,
G,
H [auth I]
IPR035965PAS domain superfamilyHomologous Superfamily
E,
F,
G,
H [auth I]
IPR036638Helix-loop-helix DNA-binding domain superfamilyHomologous Superfamily
E,
F,
G,
H [auth I]
IPR037077Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyHomologous Superfamily
E,
F,
G,
H [auth I]
IPR013767PAS foldDomain
E,
F,
G,
H [auth I]
IPR000014PAS domainDomain
E,
F,
G,
H [auth I]
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A,
C [auth H]
PharosQ96RI1
B [auth D],
D [auth L]
PharosP19793
E,
F,
G,
H [auth I]
PharosQ15788