6AY7

Cartilage homing cysteine-dense-peptides

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6ay7a1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Sahara scorpion (Androctonus australis ) [TaxId: 6858 ],	SCOPe (2.08)
A	d6ay7a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Sahara scorpion (Androctonus australis ) [TaxId: 6858 ],	SCOPe (2.08)
B	d6ay7b1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	automated matches	Sahara scorpion (Androctonus australis ) [TaxId: 6858 ],	SCOPe (2.08)
B	d6ay7b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Sahara scorpion (Androctonus australis ) [TaxId: 6858 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Short-chain scorpion toxins	8065289	4003142	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Scorpion toxin-like	8065290	3000309	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Scorpion toxin-like	8065290	3000309	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Toxin_2	e6ay7A1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Toxin_2	ECOD (1.6)
B	Toxin_2	e6ay7B1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Toxin_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00451	Scorpion short toxin, BmKK2 (Toxin_2)	Scorpion short toxin, BmKK2	Members of this family, which are found in various scorpion toxins, confer potassium channel blocking activity [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Potassium channel toxin alpha-KTx 3.5	molecular function inhibitor activity channel regulator activity transporter inhibitor activity ion channel inhibitor activity ion channel regulator activity molecular function regulator activity transporter regulator activity channel inhibitor activity potassium channel regulator activity toxin activity	-	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036574	Knottin, scorpion toxin-like superfamily	Homologous Superfamily
A, B	IPR001947	Scorpion short chain toxin, potassium channel inhibitor	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.