6BML

Structure of human DHHC20 palmitoyltransferase, irreversibly inhibited by 2-bromopalmitate

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e6bmlA2	A: alpha bundles	X: Palmitoyltransferase DHHC transmembrane domain (From Topology)	H: Palmitoyltransferase DHHC transmembrane domain (From Topology)	T: Palmitoyltransferase DHHC transmembrane domain	F: UNK_F_TYPE	ECOD (1.6)
A	UNK_F_TYPE	e6bmlA1	A: few secondary structure elements	X: Zinc hairpin stack (From Topology)	H: Zinc hairpin stack (From Topology)	T: Zinc hairpin stack	F: UNK_F_TYPE	ECOD (1.6)
A	UNK_F_TYPE	e6bmlA3	A: extended segments	X: Palmitoyltransferase DHHC C-terminal domain (From Topology)	H: Palmitoyltransferase DHHC C-terminal domain (From Topology)	T: Palmitoyltransferase DHHC C-terminal domain	F: UNK_F_TYPE	ECOD (1.6)
B	UNK_F_TYPE	e6bmlB1	A: alpha bundles	X: Palmitoyltransferase DHHC transmembrane domain (From Topology)	H: Palmitoyltransferase DHHC transmembrane domain (From Topology)	T: Palmitoyltransferase DHHC transmembrane domain	F: UNK_F_TYPE	ECOD (1.6)
B	UNK_F_TYPE	e6bmlB2	A: few secondary structure elements	X: Zinc hairpin stack (From Topology)	H: Zinc hairpin stack (From Topology)	T: Zinc hairpin stack	F: UNK_F_TYPE	ECOD (1.6)
B	UNK_F_TYPE	e6bmlB3	A: extended segments	X: Palmitoyltransferase DHHC C-terminal domain (From Topology)	H: Palmitoyltransferase DHHC C-terminal domain (From Topology)	T: Palmitoyltransferase DHHC C-terminal domain	F: UNK_F_TYPE	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01529	DHHC palmitoyltransferase (DHHC)	DHHC palmitoyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	human DHHC20 palmitoyltransferase	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding protein-cysteine S-stearoyltransferase activity protein-cysteine S-acyltransferase activity catalytic activity, acting on a protein acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity S-acyltransferase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding protein-cysteine S-stearoyltransferase activity protein-cysteine S-acyltransferase activity catalytic activity, acting on a protein acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity S-acyltransferase activity catalytic activity protein-cysteine S-palmitoyltransferase activity palmitoyltransferase activity myristoyltransferase activity protein-cysteine S-myristoyltransferase activity	cellular biosynthetic process lipoprotein biosynthetic process cellular metabolic process lipoprotein metabolic process primary metabolic process macromolecule biosynthetic process protein acylation protein lipidation protein palmitoylation biosynthetic process macromolecule modification metabolic process cellular process protein metabolic process cellular biosynthetic process lipoprotein biosynthetic process cellular metabolic process lipoprotein metabolic process primary metabolic process macromolecule biosynthetic process protein acylation protein lipidation protein palmitoylation biosynthetic process macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process modulation by host of viral process biological process involved in interspecies interaction between organisms viral process modulation by host of symbiont process positive regulation by host of viral process biological process involved in interaction with symbiont biological process involved in symbiotic interaction peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine peptidyl-cysteine modification peptidyl-amino acid modification peptidyl-L-cysteine S-palmitoylation protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization cellular macromolecule localization macromolecule localization vesicle organization cellular component organization developmental process synaptic vesicle maturation organelle organization cellular component organization or biogenesis developmental maturation	membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system Golgi membrane bounding membrane of organelle organelle membrane endoplasmic reticulum-Golgi intermediate compartment membrane membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system Golgi membrane bounding membrane of organelle organelle membrane endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment perinuclear region of cytoplasm cell periphery plasma membrane endoplasmic reticulum organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001594	Palmitoyltransferase, DHHC domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q5W0Z9	malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia spina bifida pancreatic ductal adenocarcinoma rheumatoid arthritis pancreatic intraductal papillary-mucinous neoplasm Sjogren syndrome

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM				DHHC palmitoyltransferase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	S-acyltransferases	DHHC palmitoyltransferase, P2₁ space group

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.