6CYQ

Crystal structure of CTX-M-14 S70G/N106S beta-lactamase in complex with hydrolyzed cefotaxime


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Bd6cyqb_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like beta-Lactamase/D-ala carboxypeptidase automated matches (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Cd6cyqc_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like beta-Lactamase/D-ala carboxypeptidase automated matches (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Dd6cyqd_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like beta-Lactamase/D-ala carboxypeptidase automated matches (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Fd6cyqf_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like beta-Lactamase/D-ala carboxypeptidase automated matches (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad6cyqa_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like beta-Lactamase/D-ala carboxypeptidase automated matches (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ed6cyqe_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like beta-Lactamase/D-ala carboxypeptidase automated matches (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Gd6cyqg_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like beta-Lactamase/D-ala carboxypeptidase automated matches (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Hd6cyqh_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like beta-Lactamase/D-ala carboxypeptidase automated matches (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069815 3001604 SCOP2B (2022-06-29)
CSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069815 3001604 SCOP2B (2022-06-29)
DSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069815 3001604 SCOP2B (2022-06-29)
FSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069815 3001604 SCOP2B (2022-06-29)
ASCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069815 3001604 SCOP2B (2022-06-29)
ESCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069815 3001604 SCOP2B (2022-06-29)
GSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069815 3001604 SCOP2B (2022-06-29)
HSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069815 3001604 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BPeptidase_S11_1st_1e6cyqB1 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Peptidase_S11_1st_1ECOD (1.6)
BBeta-lactamase2e6cyqB2 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase2ECOD (1.6)
CPeptidase_S11_1st_1e6cyqC2 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Peptidase_S11_1st_1ECOD (1.6)
CBeta-lactamase2e6cyqC1 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase2ECOD (1.6)
DPeptidase_S11_1st_1e6cyqD2 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Peptidase_S11_1st_1ECOD (1.6)
DBeta-lactamase2e6cyqD1 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase2ECOD (1.6)
FPeptidase_S11_1st_1e6cyqF2 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Peptidase_S11_1st_1ECOD (1.6)
FBeta-lactamase2e6cyqF1 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase2ECOD (1.6)
APeptidase_S11_1st_1e6cyqA2 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Peptidase_S11_1st_1ECOD (1.6)
ABeta-lactamase2e6cyqA1 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase2ECOD (1.6)
EPeptidase_S11_1st_1e6cyqE1 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Peptidase_S11_1st_1ECOD (1.6)
EBeta-lactamase2e6cyqE2 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase2ECOD (1.6)
GPeptidase_S11_1st_1e6cyqG1 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Peptidase_S11_1st_1ECOD (1.6)
GBeta-lactamase2e6cyqG2 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase2ECOD (1.6)
HPeptidase_S11_1st_1e6cyqH2 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Peptidase_S11_1st_1ECOD (1.6)
HBeta-lactamase2e6cyqH1 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B, C, D, E
ARO:3000016CTX-M beta-lactamasecephalosporinantibiotic inactivationCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF13354Beta-lactamase enzyme family (Beta-lactamase2)Beta-lactamase enzyme familyThis is the catalytic domain of class A beta-lactamases [1]. It is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxype ...This is the catalytic domain of class A beta-lactamases [1]. It is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.
Domain

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR045155Beta-lactamase class A, catalytic domainDomain
A, B, C, D, E
IPR012338Beta-lactamase/transpeptidase-likeHomologous Superfamily
A, B, C, D, E
IPR000871Beta-lactamase, class-AFamily
A, B, C, D, E
IPR023650Beta-lactamase, class-A active siteActive Site