6DXD

Crystal structure of chalcone synthase from Arabidopsis thaliana - C347S mutant

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d6dxdb1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Chalcone synthase-like	automated matches	Mouse-ear cress (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
C	d6dxdc1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Chalcone synthase-like	automated matches	Mouse-ear cress (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
A	d6dxda1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Chalcone synthase-like	automated matches	Mouse-ear cress (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
D	d6dxdd1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Chalcone synthase-like	automated matches	Mouse-ear cress (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	ACP_syn_III_C	e6dxdB2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ACP_syn_III_C	ECOD (1.6)
B	Chal_sti_synt_N	e6dxdB1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Chal_sti_synt_N	ECOD (1.6)
C	ACP_syn_III_C	e6dxdC1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ACP_syn_III_C	ECOD (1.6)
C	Chal_sti_synt_N	e6dxdC2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Chal_sti_synt_N	ECOD (1.6)
A	ACP_syn_III_C	e6dxdA1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ACP_syn_III_C	ECOD (1.6)
A	Chal_sti_synt_N	e6dxdA2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Chal_sti_synt_N	ECOD (1.6)
D	ACP_syn_III_C	e6dxdD1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ACP_syn_III_C	ECOD (1.6)
D	Chal_sti_synt_N	e6dxdD2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Chal_sti_synt_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
C	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
A	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
D	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00195	Chalcone and stilbene synthases, N-terminal domain (Chal_sti_synt_N)	Chalcone and stilbene synthases, N-terminal domain	The C-terminal domain of Chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in this N-terminal domain.	Domain
A, B, C, D	PF02797	Chalcone and stilbene synthases, C-terminal domain (Chal_sti_synt_C)	Chalcone and stilbene synthases, C-terminal domain	This domain of chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in the N-terminal domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Chalcone synthase	acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity naringenin-chalcone synthase activity	flavonoid metabolic process flavonoid biosynthetic process biosynthetic process metabolic process cellular process anthocyanin-containing compound biosynthetic process regulation of biosynthetic process pigment metabolic process regulation of biological process regulation of cellular process regulation of anthocyanin biosynthetic process biological regulation pigment biosynthetic process primary metabolic process flavonoid metabolic process flavonoid biosynthetic process biosynthetic process metabolic process cellular process anthocyanin-containing compound biosynthetic process regulation of biosynthetic process pigment metabolic process regulation of biological process regulation of cellular process regulation of anthocyanin biosynthetic process biological regulation pigment biosynthetic process primary metabolic process regulation of primary metabolic process regulation of flavonoid biosynthetic process anthocyanin-containing compound metabolic process regulation of metabolic process regulation of anthocyanin metabolic process response to stimulus response to stress response to wounding response to auxin response to hormone response to endogenous stimulus response to chemical response to light stimulus response to radiation response to abiotic stimulus response to UV response to UV-B response to lipid response to jasmonic acid response to fatty acid response to oxygen-containing compound response to oxidative stress response to gravity localization auxin polar transport transport regulation of hormone levels auxin transport hormone transport regulation of biological quality establishment of localization	membrane-bounded organelle vacuolar membrane plant-type vacuole membrane intracellular anatomical structure membrane vacuole intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure bounding membrane of organelle organelle plant-type vacuole cytoplasm organelle membrane membrane-bounded organelle vacuolar membrane plant-type vacuole membrane intracellular anatomical structure membrane vacuole intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure bounding membrane of organelle organelle plant-type vacuole cytoplasm organelle membrane nucleus endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001099	Chalcone/stilbene synthase, N-terminal	Domain
A, B, C, D	IPR016039	Thiolase-like	Homologous Superfamily
A, B, C, D	IPR012328	Chalcone/stilbene synthase, C-terminal	Domain
A, B, C, D	IPR011141	Polyketide synthase, type III	Family
A, B, C, D	IPR018088	Chalcone/stilbene synthase, active site	Active Site

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D	CSD	Parent Component: CYS RESID: AA0262 PSI-MOD : L-cysteine sulfinic acid MOD:00267

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.