6DY2

Guinea pig N-acylethanolamine-hydrolyzing acid amidase (NAAA) covalently bound to beta-lactam inhibitor ARN726

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	UNK_F_TYPE	e6dy2B1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Penicillin acylase, catalytic domain	F: UNK_F_TYPE	ECOD (1.6)
D	UNK_F_TYPE	e6dy2D1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Penicillin acylase, catalytic domain	F: UNK_F_TYPE	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF15508	beta subunit of N-acylethanolamine-hydrolyzing acid amidase (NAAA-beta)	beta subunit of N-acylethanolamine-hydrolyzing acid amidase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	N-acylethanolamine acid amidase alpha-subunit	N-(long-chain-acyl)ethanolamine deacylase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds fatty acid amide hydrolase activity N-acylsphingosine amidohydrolase activity	fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process lipid catabolic process catabolic process fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process lipid catabolic process catabolic process phosphatidylethanolamine metabolic process glycerophospholipid metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process glycerolipid metabolic process amide metabolic process N-acylphosphatidylethanolamine metabolic process phosphorus metabolic process membrane lipid metabolic process polyol metabolic process organic hydroxy compound metabolic process sphingolipid metabolic process alcohol metabolic process sphingosine metabolic process sphingoid metabolic process diol metabolic process N-acylethanolamine metabolic process amine metabolic process ethanolamine-containing compound metabolic process biogenic amine metabolic process primary alcohol metabolic process	membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle lytic vacuole vacuole cytoplasm intracellular membrane-bounded organelle lysosome
B, D	N-acylethanolamine acid amidase beta-subunit	N-(long-chain-acyl)ethanolamine deacylase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds fatty acid amide hydrolase activity N-acylsphingosine amidohydrolase activity	fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process lipid catabolic process catabolic process fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process cellular lipid metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process lipid catabolic process catabolic process phosphatidylethanolamine metabolic process glycerophospholipid metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process glycerolipid metabolic process amide metabolic process N-acylphosphatidylethanolamine metabolic process phosphorus metabolic process membrane lipid metabolic process polyol metabolic process organic hydroxy compound metabolic process sphingolipid metabolic process alcohol metabolic process sphingosine metabolic process sphingoid metabolic process diol metabolic process N-acylethanolamine metabolic process amine metabolic process ethanolamine-containing compound metabolic process biogenic amine metabolic process primary alcohol metabolic process	membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle lytic vacuole vacuole cytoplasm intracellular membrane-bounded organelle lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR029130	Acid ceramidase, N-terminal	Domain
A, C	IPR016699	Acid ceramidase-like	Family
B, D	IPR029130	Acid ceramidase, N-terminal	Domain
B, D	IPR016699	Acid ceramidase-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.