6E7W

Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-115

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AANF_receptor_3rde6e7wA1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_3rdECOD (1.6)
AANF_receptor_2nde6e7wA2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_2ndECOD (1.6)
CANF_receptor_3rde6e7wC1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_3rdECOD (1.6)
CANF_receptor_2nde6e7wC2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_2ndECOD (1.6)
BANF_receptor_3rde6e7wB2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_3rdECOD (1.6)
BANF_receptor_2nde6e7wB1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_2ndECOD (1.6)
DANF_receptor_3rde6e7wD2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_3rdECOD (1.6)
DANF_receptor_2nde6e7wD1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_2ndECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.2300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Response regulatorCATH (4.3.0)
C3.40.50.2300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Response regulatorCATH (4.3.0)
B3.40.50.2300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Response regulatorCATH (4.3.0)
D3.40.50.2300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Response regulatorCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF01094Receptor family ligand binding region (ANF_receptor)Receptor family ligand binding region- Family
B, D
PF01094Receptor family ligand binding region (ANF_receptor)Receptor family ligand binding region- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
Glutamate receptor ionotropic, NMDA 1
B, D
Glutamate receptor ionotropic, NMDA 2B

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C
IPR028082Periplasmic binding protein-like IHomologous Superfamily
A, C
IPR049873Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domainDomain
A, C
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
A, C
IPR015683Ionotropic glutamate receptorFamily
A, C
IPR049872Glutamate [NMDA] receptor subunit 1-like, ligand-binding domainDomain
A, C
IPR001508Ionotropic glutamate receptor, metazoaFamily
A, C
IPR001320Ionotropic glutamate receptor, C-terminalDomain
A, C
IPR001828Receptor, ligand binding regionDomain
B, D
IPR018884Glutamate [NMDA] receptor, epsilon subunit, C-terminalDomain
B, D
IPR028082Periplasmic binding protein-like IHomologous Superfamily
B, D
IPR001828Receptor, ligand binding regionDomain
B, D
IPR001320Ionotropic glutamate receptor, C-terminalDomain
B, D
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
B, D
IPR001508Ionotropic glutamate receptor, metazoaFamily
B, D
IPR015683Ionotropic glutamate receptorFamily

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

ChainsResource LinkGroupSubgroupProtein
A, B, C, D
mpstrucTRANSMEMBRANE PROTEINS: ALPHA-HELICALChannels: Other Ion ChannelsGluN1b-GluN2B NMDA receptor heterodimer, amino-terminal domains bound to allosteric inhibitor 93-4