Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6eg8a_ All beta proteins 7-bladed beta-propeller WD40 repeat-like WD40-repeat beta1-subunit of the signal-transducing G protein heterotrimer Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd6eg8b1 All beta proteins 7-bladed beta-propeller WD40 repeat-like WD40-repeat beta1-subunit of the signal-transducing G protein heterotrimer Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd6eg8b2 Artifacts Tags Tags Tags N-terminal Tags Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd6eg8d1 All beta proteins 7-bladed beta-propeller WD40 repeat-like WD40-repeat beta1-subunit of the signal-transducing G protein heterotrimer Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd6eg8d2 Artifacts Tags Tags Tags N-terminal Tags Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd6eg8f1 All beta proteins 7-bladed beta-propeller WD40 repeat-like WD40-repeat beta1-subunit of the signal-transducing G protein heterotrimer Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd6eg8f2 Artifacts Tags Tags Tags N-terminal Tags Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd6eg8c_ All alpha proteins Non-globular all-alpha subunits of globular proteins Transducin (heterotrimeric G protein), gamma chain Transducin (heterotrimeric G protein), gamma chain Transducin (heterotrimeric G protein), gamma chain Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed6eg8e_ All alpha proteins Non-globular all-alpha subunits of globular proteins Transducin (heterotrimeric G protein), gamma chain Transducin (heterotrimeric G protein), gamma chain Transducin (heterotrimeric G protein), gamma chain Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Gd6eg8g_ All alpha proteins Non-globular all-alpha subunits of globular proteins Transducin (heterotrimeric G protein), gamma chain Transducin (heterotrimeric G protein), gamma chain Transducin (heterotrimeric G protein), gamma chain Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Hd6eg8h_ All alpha proteins Non-globular all-alpha subunits of globular proteins Transducin (heterotrimeric G protein), gamma chain Transducin (heterotrimeric G protein), gamma chain Transducin (heterotrimeric G protein), gamma chain Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
CSCOP2B SuperfamilyTransducin (heterotrimeric G protein), gamma chain 8070798 3001771 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyTransducin (heterotrimeric G protein), gamma chain 8070798 3001771 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyTransducin (heterotrimeric G protein), gamma chain 8070798 3001771 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyTransducin (heterotrimeric G protein), gamma chain 8070798 3001771 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
IG-alphae6eg8I1 A: alpha arraysX: Transducin (alpha subunit), insertion domain (From Topology)H: Transducin (alpha subunit), insertion domain (From Topology)T: Transducin (alpha subunit), insertion domainF: G-alphaECOD (1.6)
IRase6eg8I2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
JG-alphae6eg8J1 A: alpha arraysX: Transducin (alpha subunit), insertion domain (From Topology)H: Transducin (alpha subunit), insertion domain (From Topology)T: Transducin (alpha subunit), insertion domainF: G-alphaECOD (1.6)
JRase6eg8J2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
LG-alphae6eg8L2 A: alpha arraysX: Transducin (alpha subunit), insertion domain (From Topology)H: Transducin (alpha subunit), insertion domain (From Topology)T: Transducin (alpha subunit), insertion domainF: G-alphaECOD (1.6)
LRase6eg8L1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
KG-alphae6eg8K1 A: alpha arraysX: Transducin (alpha subunit), insertion domain (From Topology)H: Transducin (alpha subunit), insertion domain (From Topology)T: Transducin (alpha subunit), insertion domainF: G-alphaECOD (1.6)
KRase6eg8K2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
AANAPC4_WD40_3e6eg8A1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_3ECOD (1.6)
BANAPC4_WD40_3e6eg8B1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_3ECOD (1.6)
DANAPC4_WD40_3e6eg8D1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_3ECOD (1.6)
FANAPC4_WD40_3e6eg8F1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_3ECOD (1.6)
CG-gammae6eg8C1 A: extended segmentsX: Transducin (heterotrimeric G protein), gamma chain (From Topology)H: Transducin (heterotrimeric G protein), gamma chain (From Topology)T: Transducin (heterotrimeric G protein), gamma chainF: G-gammaECOD (1.6)
EG-gammae6eg8E1 A: extended segmentsX: Transducin (heterotrimeric G protein), gamma chain (From Topology)H: Transducin (heterotrimeric G protein), gamma chain (From Topology)T: Transducin (heterotrimeric G protein), gamma chainF: G-gammaECOD (1.6)
GG-gammae6eg8G1 A: extended segmentsX: Transducin (heterotrimeric G protein), gamma chain (From Topology)H: Transducin (heterotrimeric G protein), gamma chain (From Topology)T: Transducin (heterotrimeric G protein), gamma chainF: G-gammaECOD (1.6)
HG-gammae6eg8H1 A: extended segmentsX: Transducin (heterotrimeric G protein), gamma chain (From Topology)H: Transducin (heterotrimeric G protein), gamma chain (From Topology)T: Transducin (heterotrimeric G protein), gamma chainF: G-gammaECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
I3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (utative)
I1.10.400.10 Mainly Alpha Orthogonal Bundle GI Alpha 1, domain 2-like GI Alpha 1, domain 2-likeCATH (utative)
J3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (utative)
J1.10.400.10 Mainly Alpha Orthogonal Bundle GI Alpha 1, domain 2-like GI Alpha 1, domain 2-likeCATH (utative)
L3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (utative)
L1.10.400.10 Mainly Alpha Orthogonal Bundle GI Alpha 1, domain 2-like GI Alpha 1, domain 2-likeCATH (utative)
K3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (utative)
K1.10.400.10 Mainly Alpha Orthogonal Bundle GI Alpha 1, domain 2-like GI Alpha 1, domain 2-likeCATH (utative)
A2.130.10.10 Mainly Beta 7 Propeller Methylamine Dehydrogenase Chain HCATH (utative)
B2.130.10.10 Mainly Beta 7 Propeller Methylamine Dehydrogenase Chain HCATH (utative)
D2.130.10.10 Mainly Beta 7 Propeller Methylamine Dehydrogenase Chain HCATH (utative)
F2.130.10.10 Mainly Beta 7 Propeller Methylamine Dehydrogenase Chain HCATH (utative)
C4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chainCATH (utative)
E4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chainCATH (utative)
G4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chainCATH (utative)
H4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chainCATH (utative)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
I, J, K, L
PF00503G-protein alpha subunit (G-alpha)G-protein alpha subunitG proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like ...G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site [3]. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA [3].
Domain
A, B, D, F
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
C, E, G, H
PF00631GGL domain (G-gamma)GGL domainG-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins [1]. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA [2] ...G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins [1]. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA [2]. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta [2]. All organisms that posses a G-beta possess a G-gamma [2].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
I, J, K, L
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
A, B, D, F
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
C, E, G, H
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
I, J, K, L
PharosP63092
A, B, D, F
PharosP62873
C, E, G, H
PharosP59768