6EOT

DPP8 - SLRFLYEG, space group 19

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6eotA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
A	Hydrolase_4	e6eotA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
C [auth B]	F_UNCLASSIFIED	e6eotB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth B]	Hydrolase_4	e6eotB2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
G	F_UNCLASSIFIED	e6eotG1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
G	Hydrolase_4	e6eotG2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
E [auth D]	F_UNCLASSIFIED	e6eotD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth D]	Hydrolase_4	e6eotD2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
I	F_UNCLASSIFIED	e6eotI1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
I	Hydrolase_4	e6eotI2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
K	F_UNCLASSIFIED	e6eotK2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: F_UNCLASSIFIED	ECOD (1.6)
K	Hydrolase_4	e6eotK1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B], E [auth D], G, I, A, C [auth B], E [auth D], G, I, K	PF00930	Dipeptidyl peptidase IV (DPP IV) N-terminal region (DPPIV_N)	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	Repeat
A, C [auth B], E [auth D], G, I, A, C [auth B], E [auth D], G, I, K	PF00326	Prolyl oligopeptidase family (Peptidase_S9)	Prolyl oligopeptidase family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth F], D [auth C], F [auth E], H, J, B [auth F], D [auth C], F [auth E], H, J, L	SER-LEU-ARG-PHE-LEU-TYR-GLU-GLY	protein binding binding small protein activating enzyme binding enzyme binding RNA binding organic cyclic compound binding nucleic acid binding ubiquitin-specific protease binding protease binding transcription factor binding ubiquitin-like protein ligase binding protein tag activity molecular tag activity potassium channel regulator activity protein binding binding small protein activating enzyme binding enzyme binding RNA binding organic cyclic compound binding nucleic acid binding ubiquitin-specific protease binding protease binding transcription factor binding ubiquitin-like protein ligase binding protein tag activity molecular tag activity potassium channel regulator activity channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity ubiquitin protein ligase binding	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process heart process multicellular organismal process system process regulation of actin filament-based process regulation of heart contraction regulation of system process cardiac muscle contraction striated muscle contraction circulatory system process actin filament-based process regulation of multicellular organismal process blood circulation cardiac muscle cell contraction regulation of cardiac muscle contraction actin filament-based movement muscle contraction muscle system process regulation of muscle system process regulation of blood circulation regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction actin-mediated cell contraction heart contraction protein localization negative regulation of protein transport regulation of localization establishment of protein localization cellular localization negative regulation of nucleocytoplasmic transport nitrogen compound transport nucleocytoplasmic transport regulation of protein localization transport nuclear transport negative regulation of intracellular protein transport regulation of protein localization to nucleus negative regulation of transport negative regulation of protein import into nucleus localization import into nucleus regulation of protein import into nucleus cellular macromolecule localization establishment of localization in cell protein import into nucleus regulation of intracellular transport negative regulation of protein localization negative regulation of intracellular transport regulation of transport regulation of establishment of protein localization negative regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of localization negative regulation of protein localization to nucleus establishment of protein localization to organelle protein transport regulation of cellular localization macromolecule localization protein localization to organelle regulation of intracellular protein transport intracellular protein transport regulation of protein stability regulation of biological quality protein stabilization negative regulation of DNA-binding transcription factor activity negative regulation of molecular function regulation of molecular function regulation of DNA-binding transcription factor activity positive regulation of cellular component organization regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of biological process regulation of cellular component biogenesis cellular component organization cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process cellular response to stimulus cellular response to heat response to stimulus cellular response to stress response to stress response to heat response to abiotic stimulus response to temperature stimulus protein localization to nuclear pore protein localization to nuclear envelope peptidyl-lysine modification protein sumoylation macromolecule modification peptidyl-amino acid modification protein metabolic process protein modification process post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process regulation of protein metabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process nuclear body organization nucleus organization organelle organization PML body organization negative regulation of ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity regulation of delayed rectifier potassium channel activity negative regulation of voltage-gated potassium channel activity negative regulation of cation transmembrane transport monoatomic cation transport regulation of potassium ion transmembrane transporter activity regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport regulation of cation channel activity inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport potassium ion transport regulation of potassium ion transport negative regulation of cation channel activity monoatomic ion transmembrane transport negative regulation of monoatomic ion transport regulation of transmembrane transporter activity potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport negative regulation of transmembrane transport metal ion transport regulation of transporter activity monoatomic cation transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of delayed rectifier potassium channel activity monoatomic ion transport regulation of metal ion transport negative regulation of potassium ion transport regulation of monoatomic ion transmembrane transporter activity negative regulation of transporter activity negative regulation of potassium ion transmembrane transport regulation of monoatomic cation transmembrane transport regulation of action potential negative regulation of action potential action potential regulation of membrane potential DNA metabolic process DNA damage response DNA repair regulation of DNA binding regulation of binding negative regulation of binding negative regulation of DNA binding cellular response to metal ion cellular response to chemical stimulus response to metal ion response to chemical cellular response to cadmium ion response to cadmium ion regulation of calcium ion transport calcium ion transport regulation of calcium ion transmembrane transport calcium ion transmembrane transport negative regulation of transcription by transcription factor localization developmental process anatomical structure development roof of mouth development	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen nuclear speck nuclear body nucleoplasm nuclear membrane membrane endomembrane system organelle envelope nuclear envelope organelle membrane cytoplasm cytosol XY body sex chromosome chromosome cell periphery plasma membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear stress granule ribonucleoprotein granule supramolecular complex PML body
A, C [auth B], E [auth D], G, I, A, C [auth B], E [auth D], G, I, K	Dipeptidyl peptidase 8	peptidase activity catalytic activity, acting on a protein dipeptidyl-peptidase activity hydrolase activity exopeptidase activity catalytic activity serine hydrolase activity serine-type peptidase activity aminopeptidase activity	response to stimulus immune response immune system process cellular process apoptotic process cell death programmed cell death proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process regulation of biological process regulation of cellular process response to stimulus immune response immune system process cellular process apoptotic process cell death programmed cell death proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process regulation of biological process regulation of cellular process negative regulation of programmed cell death biological regulation negative regulation of cellular process negative regulation of biological process regulation of programmed cell death	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth F], D [auth C], F [auth E], H, J, B [auth F], D [auth C], F [auth E], H, J, L	IPR046332	Small ubiquitin-related modifier 1, Ubl domain	Domain
B [auth F], D [auth C], F [auth E], H, J, B [auth F], D [auth C], F [auth E], H, J, L	IPR000626	Ubiquitin-like domain	Domain
B [auth F], D [auth C], F [auth E], H, J, B [auth F], D [auth C], F [auth E], H, J, L	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
B [auth F], D [auth C], F [auth E], H, J, B [auth F], D [auth C], F [auth E], H, J, L	IPR022617	Rad60/SUMO-like domain	Domain
A, C [auth B], E [auth D], G, I, A, C [auth B], E [auth D], G, I, K	IPR045785	Dipeptidyl peptidase 8 /9 ,N-terminal	Domain
A, C [auth B], E [auth D], G, I, A, C [auth B], E [auth D], G, I, K	IPR050278	Serine protease S9B/DPPIV	Family
A, C [auth B], E [auth D], G, I, A, C [auth B], E [auth D], G, I, K	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A, C [auth B], E [auth D], G, I, A, C [auth B], E [auth D], G, I, K	IPR001375	Peptidase S9, prolyl oligopeptidase, catalytic domain	Domain
A, C [auth B], E [auth D], G, I, A, C [auth B], E [auth D], G, I, K	IPR002469	Dipeptidylpeptidase IV, N-terminal domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth F], D [auth C], F [auth E], H, J, B [auth F], D [auth C], F [auth E], H, J, L	Pharos: P63165	orofacial cleft 10 cleft palate Neoplasm Invasiveness cleft lip pancreatic intraductal papillary-mucinous neoplasm
A, C [auth B], E [auth D], G, I, A, C [auth B], E [auth D], G, I, K	Pharos: Q6V1X1	atypical teratoid rhabdoid tumor lymphoplasmacytic lymphoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia glioblastoma malignant glioma ovarian cancer plasma cell myeloma large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm type 2 diabetes mellitus

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.