6FC0

Crystal structure of the eIF4E-eIF4G complex from Chaetomium thermophilum

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6fc0a1	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	(Thermochaetoides thermophila DSM 1495 ) [TaxId: 759272 ],	SCOPe (2.08)
A	d6fc0a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Thermochaetoides thermophila DSM 1495 ) [TaxId: 759272 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Translation initiation factor eIF4e	8072939	4001578	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	eIF4e-like	8072940	3001871	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IF4E	e6fc0A1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: IF4E	ECOD (1.6)
B	UNK_F_TYPE	e6fc0B1	A: alpha arrays	X: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain (From Topology)	H: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain (From Topology)	T: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01652	Eukaryotic initiation factor 4E (IF4E)	Eukaryotic initiation factor 4E	-	Domain
B	PF12152	Eukaryotic translation initiation factor 4G1 (eIF_4G1)	Eukaryotic translation initiation factor 4G1	This domain is found in eukaryotes, and is about 80 amino acids in length. It is found in association with Pfam:PF02854. This domain is part of the protein eIF_4G. It binds to eIF_4E by wrapping around its N terminal to form the eIF_4F complex. This ...	This domain is found in eukaryotes, and is about 80 amino acids in length. It is found in association with Pfam:PF02854. This domain is part of the protein eIF_4G. It binds to eIF_4E by wrapping around its N terminal to form the eIF_4F complex. This complex binds various eIF_4E-BPs (binding proteins) to regulate initiation of translation.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Eukaryotic translation initiation factor 4E-like protein	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding RNA binding	-	cellular anatomical structure intracellular anatomical structure cytoplasm
B	Eukaryotic translation initiation factor 4G	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding RNA binding mRNA binding	-	protein-containing complex eukaryotic translation initiation factor 4F complex cellular anatomical structure intracellular anatomical structure RNA cap binding complex cytoplasm intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR023398	Translation Initiation factor eIF- 4e-like	Homologous Superfamily
A	IPR019770	Eukaryotic translation initiation factor 4E (eIF-4E), conserved site	Conserved Site
A	IPR001040	Translation Initiation factor eIF- 4e	Family
B	IPR036211	eIF4G, eIF4e-binding domain superfamily	Homologous Superfamily
B	IPR003890	MIF4G-like, type 3	Domain
B	IPR045208	IF4G	Unknown
B	IPR016024	Armadillo-type fold	Homologous Superfamily
B	IPR022745	Eukaryotic translation initiation factor 4G1, eIF4E-binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.