6FMD

Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6fmda_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	FMN-linked oxidoreductases	FMN-linked oxidoreductases	Dihydroorotate dehydrogenase	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	FMN-linked oxidoreductases	8044611	3000014	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DHO_dh	e6fmdA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: DHO_dh	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01180	Dihydroorotate dehydrogenase (DHO_dh)	Dihydroorotate dehydrogenase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Dihydroorotate dehydrogenase (quinone), mitochondrial	dihydroorotase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds dihydroorotate dehydrogenase (quinone) activity oxidoreductase activity dihydroorotate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	ribose phosphate metabolic process pyrimidine nucleoside diphosphate metabolic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process UDP metabolic process nucleobase-containing compound metabolic process nucleoside diphosphate biosynthetic process ribonucleotide biosynthetic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process pyrimidine ribonucleoside diphosphate metabolic process ribonucleoside diphosphate metabolic process phosphate-containing compound metabolic process ribose phosphate metabolic process pyrimidine nucleoside diphosphate metabolic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process UDP metabolic process nucleobase-containing compound metabolic process nucleoside diphosphate biosynthetic process ribonucleotide biosynthetic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process pyrimidine ribonucleoside diphosphate metabolic process ribonucleoside diphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process pyrimidine-containing compound biosynthetic process phosphorus metabolic process ribose phosphate biosynthetic process pyrimidine ribonucleotide metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process pyrimidine-containing compound metabolic process cellular metabolic process primary metabolic process pyrimidine ribonucleoside diphosphate biosynthetic process nucleobase-containing compound biosynthetic process nucleotide metabolic process nucleoside diphosphate metabolic process UDP biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process pyrimidine nucleoside diphosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process pyrimidine nucleotide biosynthetic process ribonucleoside diphosphate biosynthetic process pyrimidine ribonucleotide biosynthetic process nucleobase biosynthetic process pyrimidine nucleobase biosynthetic process pyrimidine nucleobase metabolic process nucleobase metabolic process 'de novo' pyrimidine nucleobase biosynthetic process 'de novo' UMP biosynthetic process UMP biosynthetic process ribonucleoside monophosphate metabolic process UMP metabolic process nucleoside monophosphate metabolic process pyrimidine nucleoside monophosphate metabolic process pyrimidine ribonucleoside monophosphate metabolic process nucleoside monophosphate biosynthetic process pyrimidine ribonucleoside monophosphate biosynthetic process pyrimidine nucleoside monophosphate biosynthetic process ribonucleoside monophosphate biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A	IPR005719	Dihydroorotate dehydrogenase, class 2	Family
A	IPR005720	Dihydroorotate dehydrogenase, catalytic	Domain
A	IPR001295	Dihydroorotate dehydrogenase, conserved site	Conserved Site
A	IPR050074	Dihydroorotate dehydrogenase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q02127	postaxial acrofacial dysostosis sickle cell anemia beta thalassemia hereditary spherocytosis acute erythroid leukemia heart disease intellectual disability osteosarcoma psoriasis hereditary persistence of fetal hemoglobin malignant mesothelioma pancreatic ductal adenocarcinoma psoriatic arthritis Thalassemia Intermedia multiple sclerosis postaxial acrofacial dysostosis sickle cell anemia beta thalassemia hereditary spherocytosis acute erythroid leukemia heart disease intellectual disability osteosarcoma psoriasis hereditary persistence of fetal hemoglobin malignant mesothelioma pancreatic ductal adenocarcinoma psoriatic arthritis Thalassemia Intermedia multiple sclerosis rheumatoid arthritis thalassemia minor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.