6HKQ

Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6hkqa1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d6hkqa2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GSHPx	e6hkqA1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: GSHPx	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00255	Glutathione peroxidase (GSHPx)	Glutathione peroxidase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Phospholipid hydroperoxide glutathione peroxidase	phospholipid-hydroperoxide glutathione peroxidase activity peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity glutathione peroxidase activity identical protein binding protein binding binding selenium binding small molecule binding	cellular component organization cellular component biogenesis protein polymerization cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction cellular component organization cellular component biogenesis protein polymerization cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation icosanoid metabolic process fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process small molecule metabolic process metabolic process lipoxygenase pathway monocarboxylic acid metabolic process lipid metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process long-chain fatty acid metabolic process unsaturated fatty acid metabolic process arachidonate metabolic process olefinic compound metabolic process response to oxidative stress response to stimulus response to stress monocarboxylic acid biosynthetic process small molecule biosynthetic process long-chain fatty acid biosynthetic process lipid biosynthetic process organic acid biosynthetic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process negative regulation of ferroptosis regulation of biological process regulation of cellular process negative regulation of programmed cell death biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of cellular process regulation of ferroptosis ferroptosis programmed cell death response to lipid response to chemical response to estradiol response to oxygen-containing compound response to organic cyclic compound chromatin organization	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle envelope nuclear envelope nucleus endomembrane system extracellular exosome extracellular vesicle membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle envelope nuclear envelope nucleus endomembrane system extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR029759	Glutathione peroxidase active site	Active Site
A	IPR029760	Glutathione peroxidase conserved site	Conserved Site
A	IPR000889	Glutathione peroxidase	Family
A	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P36969	spondylometaphyseal dysplasia, Sedaghatian type colorectal cancer Fibrosis cadmium poisoning glucose intolerance cryptorchidism male infertility breast carcinoma congestive heart failure heart failure pancreatic ductal adenocarcinoma colorectal carcinoma Crohn disease age-related macular degeneration breast cancer spondylometaphyseal dysplasia, Sedaghatian type colorectal cancer Fibrosis cadmium poisoning glucose intolerance cryptorchidism male infertility breast carcinoma congestive heart failure heart failure pancreatic ductal adenocarcinoma colorectal carcinoma Crohn disease age-related macular degeneration breast cancer plasma cell myeloma wet macular degeneration fatty liver disease inflammatory bowel disease ovarian cancer skin basal cell carcinoma ductal breast carcinoma in situ

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Monotopic/peripheral	Alpha/Beta monotopic/peripheral	Thioredoxin-like	Glutathione peroxidase

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.