6HL6

Factor Inhibiting HIF (FIH) in complex with zinc, NOG and iASPP(670-693)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Clavaminate synthase-like	8043914	3001848	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	JmjC_1	e6hl6A1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: JmjC_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (utative)
A	1.10.287.1010	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Clavaminate synthase-like	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13621	Cupin-like domain (Cupin_8)	Cupin-like domain	This cupin like domain shares similarity to the JmjC domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Hypoxia-inducible factor 1-alpha inhibitor	transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding signaling receptor binding Notch binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding NF-kappaB binding cation binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding signaling receptor binding Notch binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding NF-kappaB binding cation binding transition metal ion binding iron ion binding ion binding ferrous iron binding metal ion binding small molecule binding identical protein binding protein homodimerization activity protein dimerization activity molecular sensor activity molecular function regulator activity oxygen sensor activity ankyrin repeat binding protein domain specific binding oxidoreductase activity catalytic activity, acting on a protein oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen peptidyl-aspartic acid 3-dioxygenase activity catalytic activity 2-oxoglutarate-dependent dioxygenase activity dioxygenase activity [protein]-asparagine 3-dioxygenase activity zinc ion binding organic acid binding anion binding carboxylic acid binding peptidyl-histidine dioxygenase activity	developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development regulation of myoblast differentiation cellular process myoblast differentiation positive regulation of cellular process multicellular organismal process regulation of vasculogenesis vasculogenesis multicellular organism development tube morphogenesis blood vessel development system development blood vessel morphogenesis tube development vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculogenesis cellular response to stimulus response to stimulus negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of cellular process signal transduction regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction Notch signaling pathway negative regulation of Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
B [auth S]	RelA-associated inhibitor	transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cell adhesion molecule binding cadherin binding protein binding binding identical protein binding	cellular process apoptotic process cell death programmed cell death regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus biological regulation negative regulation of biological process response to external stimulus cellular process apoptotic process cell death programmed cell death regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus biological regulation negative regulation of biological process response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response developmental process regulation of cellular process regulation of developmental process cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation positive regulation of cellular process heart development multicellular organismal process cardiac muscle tissue development animal organ development tissue development striated muscle tissue development circulatory system development multicellular organism development ventricular cardiac muscle tissue development anatomical structure development muscle tissue development system development multicellular organismal-level homeostasis homeostatic process heart process system process circulatory system process cardiac muscle contraction heart contraction muscle contraction muscle system process blood circulation striated muscle contraction hair cycle molting cycle sensory organ development eye development visual system development embryo development embryonic camera-type eye development camera-type eye development embryonic organ development sensory system development RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process multicellular organism growth developmental growth growth cardiac chamber morphogenesis heart morphogenesis cardiac right ventricle morphogenesis anatomical structure morphogenesis cardiac ventricle morphogenesis cardiac chamber development animal organ morphogenesis cardiac ventricle development post-embryonic development	cellular anatomical structure cell junction intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle cellular anatomical structure cell junction intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intercellular bridge

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003347	JmjC domain	Domain
A	IPR027452	Hypoxia-inducible factor 1-alpha inhibitor, domain II	Homologous Superfamily
A	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily
A	IPR041667	Cupin-like domain 8	Domain
B [auth S]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
B [auth S]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
B [auth S]	IPR028320	RelA-associated inhibitor	Family
B [auth S]	IPR002110	Ankyrin repeat	Repeat
B [auth S]	IPR042722	RelA-associated inhibitor, SH3 domain	Domain
B [auth S]	IPR001452	SH3 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9NWT6	diabetes mellitus ovarian cancer large cell medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia osteosarcoma psoriasis
B [auth S]	Pharos: Q8WUF5	leukemia adenoma interstitial cystitis malignant ependymoma pituitary cancer cutaneous lupus erythematosus malignant mesothelioma spina bifida esophageal adenocarcinoma malignant colon neoplasm pancreatic ductal adenocarcinoma ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.