6I22

Flavin Analogue Sheds Light on Light-Oxygen-Voltage Domain Mechanism

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6i22a1	Alpha and beta proteins (a+b)	Profilin-like	PYP-like sensor domain (PAS domain)	automated matches	automated matches	Golden alga (Ochromonas danica ) [TaxId: 2986 ],	SCOPe (2.08)
A	d6i22a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Golden alga (Ochromonas danica ) [TaxId: 2986 ],	SCOPe (2.08)
B	d6i22b1	Alpha and beta proteins (a+b)	Profilin-like	PYP-like sensor domain (PAS domain)	automated matches	automated matches	Golden alga (Ochromonas danica ) [TaxId: 2986 ],	SCOPe (2.08)
B	d6i22b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Golden alga (Ochromonas danica ) [TaxId: 2986 ],	SCOPe (2.08)
C	d6i22c1	Alpha and beta proteins (a+b)	Profilin-like	PYP-like sensor domain (PAS domain)	automated matches	automated matches	Golden alga (Ochromonas danica ) [TaxId: 2986 ],	SCOPe (2.08)
C	d6i22c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Golden alga (Ochromonas danica ) [TaxId: 2986 ],	SCOPe (2.08)
D	d6i22d1	Alpha and beta proteins (a+b)	Profilin-like	PYP-like sensor domain (PAS domain)	automated matches	automated matches	Golden alga (Ochromonas danica ) [TaxId: 2986 ],	SCOPe (2.08)
D	d6i22d2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Golden alga (Ochromonas danica ) [TaxId: 2986 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8097434	3000471	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8097434	3000471	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8097434	3000471	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8097434	3000471	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PAS	e6i22A1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS	ECOD (1.6)
B	PAS	e6i22B1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS	ECOD (1.6)
C	PAS	e6i22C1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS	ECOD (1.6)
D	PAS	e6i22D1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (utative)
B	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (utative)
C	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (utative)
D	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF13426	PAS domain (PAS_9)	PAS domain	This domain is found in many signalling proteins in which it functions as a sensor domain. It recognises FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Aureochrome1-like protein	transcription regulator activity DNA-binding transcription factor activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding cation binding ion binding metal ion binding	-	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR035965	PAS domain superfamily	Homologous Superfamily
A, B, C, D	IPR001610	PAC motif	Repeat
A, B, C, D	IPR000700	PAS-associated, C-terminal	Domain
A, B, C, D	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily
A, B, C, D	IPR000014	PAS domain	Domain
A, B, C, D	IPR004827	Basic-leucine zipper domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.