6IEJ

The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6ieja1	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	PLC-like (P variant)	automated matches	Chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
A	d6ieja2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
C	d6iejc1	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	PLC-like (P variant)	automated matches	Chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
C	d6iejc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d6iejb1	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	PLC-like (P variant)	automated matches	Chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d6iejb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain, calb)	8093952	3000965	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	C2 domain (calcium/lipid-binding domain, calb)	8093952	3000965	SCOP2B (2022-06-29)
B	SCOP2 Family	PLC-like (P variant)	8093951	4002218	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	C2 domain (calcium/lipid-binding domain, calb)	8093952	3000965	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C2_1	e6iejA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: C2_1	ECOD (1.6)
C	C2_1	e6iejC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: C2_1	ECOD (1.6)
B	C2_1	e6iejB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: C2_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (utative)
C	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (utative)
B	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00168	C2 domain (C2)	C2 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Cytosolic phospholipase A2	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phospholipase A2 activity calcium-dependent phospholipase A2 activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phospholipase A2 activity calcium-dependent phospholipase A2 activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity lysophospholipase activity calcium-dependent phospholipid binding phospholipid binding lipid binding amide binding ceramide binding sphingolipid binding anion binding ceramide 1-phosphate binding calcium-independent phospholipase A2 activity phosphatidylinositol phosphate binding phosphatidylinositol-4-phosphate binding phosphatidylinositol binding phosphatidylinositol-5-phosphate binding phosphatidylinositol-3-phosphate binding O-acyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity	icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process leukotriene biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process icosanoid biosynthetic process small molecule metabolic process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process leukotriene biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process icosanoid biosynthetic process small molecule metabolic process metabolic process cellular process regulation of macrophage activation multicellular organismal process regulation of biological process positive regulation of macrophage activation regulation of cellular process regulation of leukocyte activation cell activation biological regulation positive regulation of biological process regulation of cell activation myeloid leukocyte activation leukocyte activation macrophage activation positive regulation of cell activation immune system process positive regulation of leukocyte activation positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of immune system process positive regulation of immune system process positive regulation of cellular process lipid catabolic process catabolic process phospholipid catabolic process glycerophospholipid metabolic process glycerolipid catabolic process organophosphate catabolic process primary metabolic process cellular lipid catabolic process phospholipid metabolic process cellular catabolic process phosphatidylcholine catabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphatidylcholine metabolic process glycerolipid metabolic process glycerophospholipid catabolic process phosphorus metabolic process lipid metabolic process glycerol ether metabolic process ether metabolic process lipid biosynthetic process platelet activating factor biosynthetic process ether biosynthetic process cellular lipid biosynthetic process ether lipid biosynthetic process platelet activating factor metabolic process glycerol ether biosynthetic process glycerophospholipid biosynthetic process phospholipid biosynthetic process glycerolipid biosynthetic process organophosphate biosynthetic process ether lipid metabolic process prostaglandin metabolic process unsaturated fatty acid metabolic process prostanoid metabolic process prostaglandin biosynthetic process prostanoid biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process monocarboxylic acid metabolic process positive regulation of T-helper 1 type immune response adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains response to stimulus immune response regulation of adaptive immune response T-helper 1 type immune response adaptive immune response regulation of T-helper 1 type immune response positive regulation of response to stimulus regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of response to stimulus positive regulation of immune response regulation of immune response positive regulation of adaptive immune response phosphatidylcholine acyl-chain remodeling organic anion transport carboxylic acid transport secretion transport arachidonate transport lipid localization lipid transport establishment of localization organic acid transport localization arachidonate secretion monocarboxylic acid transport fatty acid transport icosanoid transport macromolecule localization icosanoid secretion long-chain fatty acid transport cellular localization establishment of localization in cell neutral lipid metabolic process neutral lipid biosynthetic process acylglycerol biosynthetic process monoacylglycerol biosynthetic process monoacylglycerol metabolic process acylglycerol metabolic process cellular response to stimulus cellular response to antibiotic cellular response to chemical stimulus response to chemical response to antibiotic phosphatidylglycerol metabolic process phosphatidylglycerol catabolic process long-chain fatty acid metabolic process arachidonate metabolic process olefinic compound metabolic process cell population proliferation regulation of cell population proliferation regulation of localization cell communication regulation of prostaglandin secretion prostaglandin secretion positive regulation of icosanoid secretion regulation of fatty acid transport regulation of secretion positive regulation of lipid transport lipid export from cell prostaglandin transport signaling regulation of lipid transport positive regulation of secretion by cell regulation of secretion by cell secretion by cell positive regulation of secretion signal release regulation of icosanoid secretion positive regulation of prostaglandin secretion regulation of transport export from cell cell-cell signaling positive regulation of lipid localization positive regulation of organic acid transport positive regulation of transport regulation of lipid localization regulation of organic acid transport positive regulation of fatty acid transport regulation of body fluid levels positive regulation of platelet activation response to stress coagulation regulation of biological quality response to wounding wound healing hemostasis blood coagulation regulation of platelet activation platelet activation	membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol cytoplasmic vesicle intracellular vesicle membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol cytoplasmic vesicle intracellular vesicle vesicle Golgi apparatus Golgi membrane membrane bounding membrane of organelle organelle membrane endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
A, B, C	IPR002642	Lysophospholipase, catalytic domain	Domain
A, B, C	IPR041847	Cytosolic phospholipase A2, C2 domain	Domain
A, B, C	IPR000008	C2 domain	Domain
A, B, C	IPR035892	C2 domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.