Annotations: 6JU8

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Tyrosinase	e6ju8A1	A: alpha arrays	X: Di-copper centre-containing domain (From Topology)	H: Di-copper centre-containing domain (From Topology)	T: Di-copper centre-containing domain	F: Tyrosinase	ECOD (1.6)
B	Tyrosinase	e6ju8B1	A: alpha arrays	X: Di-copper centre-containing domain (From Topology)	H: Di-copper centre-containing domain (From Topology)	T: Di-copper centre-containing domain	F: Tyrosinase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.1280.10	Mainly Alpha	Orthogonal Bundle	di-copper center containing domain from catechol oxidase	Di-copper center containing domain from catechol oxidase	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00264	Common central domain of tyrosinase (Tyrosinase)	Common central domain of tyrosinase	This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to Pfam:PF00372.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Tyrosinase	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen oxidoreductase activity monooxygenase activity tyrosinase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen catalytic activity cation binding ion binding binding metal ion binding small molecule binding	pigment metabolic process organic hydroxy compound metabolic process pigment biosynthetic process melanin metabolic process secondary metabolic process biosynthetic process secondary metabolite biosynthetic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process phenol-containing compound biosynthetic process metabolic process melanin biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008922	Di-copper centre-containing domain superfamily	Homologous Superfamily
A, B	IPR015021	Ester hydrolase C11orf54, Domain of unknown function DUF1907	Domain
A, B	IPR041640	Tyrosinase, C-terminal	Domain
A, B	IPR050316	Tyrosinase and Hemocyanin	Family
A, B	IPR002227	Tyrosinase copper-binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.