Annotations: 6M18

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Metalloproteases (zincins), catalytic domain	8037105	3001975	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Metalloproteases (zincins), catalytic domain	8037105	3001975	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SNF	e6m18A1	A: alpha complex topology	X: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	H: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	T: Sodium:neurotransmitter symporter family (SNF)-like	F: SNF	ECOD (1.6)
C	SNF	e6m18C1	A: alpha complex topology	X: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	H: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	T: Sodium:neurotransmitter symporter family (SNF)-like	F: SNF	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00209	Sodium:neurotransmitter symporter family (SNF)	Sodium:neurotransmitter symporter family	-	Family
B, D	PF16959	Renal amino acid transporter (Collectrin)	Renal amino acid transporter	Collectrin is a single-pass transmembrane protein that is homologous to the C-terminal region of human angiotensin-converting enzyme 2, ACE2, SwissProt:Q9BYF1, found in Peptidase_M2 Pfam:PF01401 [1]. Collectrin is critical for normal amino acid reabs ...	Collectrin is a single-pass transmembrane protein that is homologous to the C-terminal region of human angiotensin-converting enzyme 2, ACE2, SwissProt:Q9BYF1, found in Peptidase_M2 Pfam:PF01401 [1]. Collectrin is critical for normal amino acid reabsorption in the kidney [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Sodium-dependent neutral amino acid transporter B(0)AT1	amino acid transmembrane transporter activity neutral L-amino acid transmembrane transporter activity transporter activity transmembrane transporter activity active transmembrane transporter activity symporter activity secondary active transmembrane transporter activity	amino acid transport localization transport neutral amino acid transport establishment of localization viral process viral life cycle response to nutrient levels response to stimulus response to chemical response to nutrient monoatomic ion transmembrane transport sodium ion transmembrane transport inorganic ion transmembrane transport amino acid transport localization transport neutral amino acid transport establishment of localization viral process viral life cycle response to nutrient levels response to stimulus response to chemical response to nutrient monoatomic ion transmembrane transport sodium ion transmembrane transport inorganic ion transmembrane transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport monoatomic ion transport cellular process monoatomic cation transport sodium ion transport	cell periphery cellular anatomical structure apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cellular anatomical structure apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle brush border membrane cluster of actin-based cell projections plasma membrane bounded cell projection brush border cell projection cell projection membrane
B, D	Angiotensin-converting enzyme 2	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding virus receptor activity exogenous protein binding peptidyl-dipeptidase activity exopeptidase activity carboxypeptidase activity endopeptidase activity cation binding peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding virus receptor activity exogenous protein binding peptidyl-dipeptidase activity exopeptidase activity carboxypeptidase activity endopeptidase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding identical protein binding	regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process signaling receptor ligand precursor processing protein maturation circulatory system process proteolysis amide metabolic process protein metabolic process regulation of biological quality blood circulation regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process signaling receptor ligand precursor processing protein maturation circulatory system process proteolysis amide metabolic process protein metabolic process regulation of biological quality blood circulation regulation of blood pressure regulation of hormone levels biological regulation regulation of systemic arterial blood pressure by circulatory renin-angiotensin primary metabolic process gene expression macromolecule biosynthetic process hormone metabolic process regulation of systemic arterial blood pressure endocrine process biosynthetic process regulation of angiotensin levels in blood protein processing metabolic process cellular process macromolecule metabolic process angiotensin maturation membrane organization cellular component organization membrane fusion cellular component organization or biogenesis heart process regulation of biological process regulation of cardiac conduction regulation of heart contraction regulation of system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process heart contraction regulation of blood volume by renin-angiotensin nervous system process feeding behavior brain renin-angiotensin system behavior drinking behavior angiotensin-mediated drinking behavior nervous system process involved in regulation of systemic arterial blood pressure viral process viral life cycle positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization gap junction assembly positive regulation of biological process cellular component biogenesis cellular component assembly positive regulation of gap junction assembly cell junction assembly positive regulation of cellular process cell-cell junction assembly cell-cell junction organization positive regulation of cellular component biogenesis regulation of gap junction assembly regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization regulation of localization regulation of transport transport regulation of transmembrane transporter activity establishment of localization regulation of transporter activity transmembrane transport regulation of molecular function localization regulation of transmembrane transport import into cell receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms biological process involved in interaction with host vesicle-mediated transport biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host endocytosis involved in viral entry into host cell endocytosis receptor-mediated endocytosis transport of virus multi-multicellular organism process maternal process involved in female pregnancy reproductive process multicellular organismal reproductive process female pregnancy multi-organism reproductive process negative regulation of cell population proliferation cell population proliferation regulation of smooth muscle cell proliferation negative regulation of biological process smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation regulation of cell population proliferation negative regulation of cellular process muscle cell proliferation regulation of tube diameter regulation of tube size regulation of vasoconstriction vascular process in circulatory system blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade regulation of signaling receptor activity negative regulation of molecular function negative regulation of signaling receptor activity regulation of biosynthetic process regulation of macromolecule metabolic process regulation of gene expression regulation of cytokine production cytokine production regulation of macromolecule biosynthetic process regulation of metabolic process reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process positive regulation of metabolic process regulation of reactive oxygen species metabolic process virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus response to stress regulation of response to stress inflammatory response nitrogen compound transport positive regulation of amine transport amine transport amino acid transport positive regulation of amino acid transport positive regulation of transport regulation of amino acid transport regulation of amine transport aromatic amino acid transport organic anion transport carboxylic acid transport organic cation transport organic acid transport tryptophan transport carboxylic acid transmembrane transport regulation of L-proline import across plasma membrane regulation of proline transport organic acid transmembrane transport import across plasma membrane L-proline transmembrane transport proline transport regulation of amino acid import across plasma membrane L-alpha-amino acid transmembrane transport amino acid import across plasma membrane proline import across plasma membrane regulation of proline import across plasma membrane positive regulation of L-proline import across plasma membrane amino acid transmembrane transport L-amino acid transport positive regulation of transmembrane transport regulation of amino acid transmembrane transport neutral amino acid transport L-proline import across plasma membrane positive regulation of organic acid transport proline transmembrane transport positive regulation of proline import across plasma membrane regulation of organic acid transport entry receptor-mediated virion attachment to host cell positive regulation of blood circulation positive regulation of cardiac muscle contraction cardiac muscle contraction striated muscle contraction positive regulation of striated muscle contraction regulation of cardiac muscle contraction muscle contraction muscle system process regulation of muscle system process positive regulation of heart contraction regulation of striated muscle contraction regulation of muscle contraction positive regulation of muscle contraction positive regulation of multicellular organismal process	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection membrane cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane extracellular exosome extracellular vesicle membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection membrane cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cell surface membrane microdomain membrane raft intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane cytoplasm organelle membrane endocytic vesicle membrane-enclosed lumen endomembrane system intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum brush border membrane cluster of actin-based cell projections brush border cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR000175	Sodium:neurotransmitter symporter	Family
A, C	IPR002438	Neutral amino acid SLC6 transporter	Family
A, C	IPR037272	Sodium:neurotransmitter symporter superfamily	Homologous Superfamily
B, D	IPR031588	Collectrin domain	Domain
B, D	IPR001548	Peptidase M2, peptidyl-dipeptidase A	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: Q695T7	Hartnup disease iminoglycinuria hyperglycinuria melanoma osteosarcoma prostate carcinoma testicular cancer atypical teratoid rhabdoid tumor brain glioma colorectal cancer estrogen-receptor negative breast cancer lung adenocarcinoma nasopharyngeal disease ovarian cancer skin basal cell carcinoma Hartnup disease iminoglycinuria hyperglycinuria melanoma osteosarcoma prostate carcinoma testicular cancer atypical teratoid rhabdoid tumor brain glioma colorectal cancer estrogen-receptor negative breast cancer lung adenocarcinoma nasopharyngeal disease ovarian cancer skin basal cell carcinoma testicular germ cell tumor B-cell chronic lymphocytic leukemia breast carcinoma cutaneous melanoma exocrine pancreatic carcinoma intellectual disability lung carcinoma non-small cell lung carcinoma ovarian carcinoma systemic lupus erythematosus uterine corpus leiomyoma benign prostatic hyperplasia colorectal adenoma Epileptic encephalopathy glioblastoma idiopathic pulmonary fibrosis large cell medulloblastoma
B, D	Pharos: Q9BYF1	endomyocardial fibrosis hypertensive disorder abdominal aortic aneurysm inborn carbohydrate metabolic disorder kidney disease Middle East respiratory syndrome obesity disorder adult acute respiratory distress syndrome pulmonary edema common cold Spontaneous abortion COVID-19–associated multisystem inflammatory syndrome in children ulcerative colitis cystic fibrosis heart disease endomyocardial fibrosis hypertensive disorder abdominal aortic aneurysm inborn carbohydrate metabolic disorder kidney disease Middle East respiratory syndrome obesity disorder adult acute respiratory distress syndrome pulmonary edema common cold Spontaneous abortion COVID-19–associated multisystem inflammatory syndrome in children ulcerative colitis cystic fibrosis heart disease influenza nephrosclerosis pneumonia cerebrovascular disorder pulmonary embolism coronary artery disease thrombotic disease Crohn disease diabetes mellitus diarrheal disease Ebola hemorrhagic fever intellectual disability lymphopenia psoriasis chronic obstructive pulmonary disease severe acute respiratory syndrome COVID-19 transitional cell carcinoma cutaneous lupus erythematosus diabetic kidney disease disseminated intravascular coagulation

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	APC (Amino acid-Polyamine-organoCation) superfamily	Neurotransmitter: sodium symporter

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Solute Carrier (SLC) Transporter Superfamily	B⁰AT1 (SLC6A19) in complex with angiotensin-converting enzyme 2 (ACE2), closed conformation

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.