6MAK

HBO1 is required for the maintenance of leukaemia stem cells

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6maka_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-acetyl transferase, NAT	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8084563	3000403	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	beta-beta-alpha zinc fingers	8093406	3001077	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MOZ_SAS_C	e6makA1	A: alpha arrays	X: HTH	H: HTH	T: HAT1, C-terminal domain	F: MOZ_SAS_C	ECOD (1.6)
A	MOZ_SAS_N	e6makA3	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: MOZ_SAS_N	ECOD (1.6)
A	PLN00104	e6makA2	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: PLN00104	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17772	MYST family zinc finger domain (zf-MYST)	MYST family zinc finger domain	This zinc finger domain is found in the MYST family of histone acetyltransferases [1].	Domain
A	PF01853	MOZ/SAS family (MOZ_SAS)	MOZ/SAS family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Histone acetyltransferase KAT7	catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity histone H3 acetyltransferase activity transferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity DNA binding catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity histone H3 acetyltransferase activity transferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding histone H4K12 acetyltransferase activity histone H4 acetyltransferase activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity histone H4K8 acetyltransferase activity chromatin binding histone H3K4 acetyltransferase activity histone H3K14 acetyltransferase activity histone H4K5 acetyltransferase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding histone H3K23 acetyltransferase activity	regulation of cellular process cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of cellular process cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis positive regulation of cellular process transcription initiation at RNA polymerase II promoter regulation of biosynthetic process regulation of biological process epigenetic regulation of gene expression cellular metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process response to stimulus response to chemical response to dithiothreitol response to oxygen-containing compound DNA metabolic process regulation of primary metabolic process DNA replication regulation of nucleobase-containing compound metabolic process regulation of DNA replication regulation of DNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of DNA replication positive regulation of DNA metabolic process response to carbohydrate response to sorbitol regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth response to actinomycin D response to nitrogen compound response to antibiotic regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of DNA-templated transcription cellular response to stimulus cellular response to stress DNA damage response response to stress DNA repair response to anisomycin developmental process regulation of stem cell proliferation cell population proliferation positive regulation of cell population proliferation cellular developmental process hemopoiesis cell development positive regulation of stem cell proliferation stem cell proliferation regulation of cell population proliferation cell differentiation positive regulation of hematopoietic stem cell proliferation anatomical structure development hematopoietic stem cell proliferation regulation of hematopoietic stem cell proliferation multicellular organismal process cell activation mononuclear cell differentiation natural killer cell activation lymphocyte differentiation lymphocyte activation leukocyte activation immune system process natural killer cell differentiation leukocyte differentiation regulation of DNA biosynthetic process DNA biosynthetic process protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization positive regulation of DNA-templated transcription positive regulation of DNA-templated transcription, elongation regulation of DNA-templated transcription elongation positive regulation of RNA metabolic process DNA-templated transcription elongation positive regulation of RNA biosynthetic process DNA replication-dependent chromatin disassembly regulation of DNA-templated DNA replication initiation DNA-templated DNA replication DNA replication initiation regulation of DNA-templated DNA replication signaling intracellular signal transduction cell communication stress-activated protein kinase signaling cascade signal transduction regulation of cellular response to stress nucleotide-excision repair regulation of response to stress regulation of DNA repair regulation of response to stimulus regulation of nucleotide-excision repair regulation of transcription by RNA polymerase II cell cycle regulation of cell cycle response to hydroxyurea peptidyl-lysine acetylation peptidyl-lysine modification protein acylation protein acetylation internal peptidyl-lysine acetylation macromolecule modification peptidyl-amino acid modification protein metabolic process protein modification process internal protein amino acid acetylation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle protein-containing complex catalytic complex transferase complex histone acetyltransferase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle protein-containing complex catalytic complex transferase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex chromosome, centromeric region chromosomal region membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen histone H3-K14 acetyltransferase complex nuclear protein-containing complex H3 histone acetyltransferase complex site of DNA damage
B	BRD1 protein	protein binding binding histone binding histone reader activity chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity cation binding ion binding metal ion binding small molecule binding	developmental process multicellular organismal process regulation of biological process regulation of multicellular organismal development regulation of cellular process cellular developmental process regulation of developmental process hemopoiesis biological regulation cell development regulation of cell differentiation regulation of cell development multicellular organism development cell differentiation immune system process developmental process multicellular organismal process regulation of biological process regulation of multicellular organismal development regulation of cellular process cellular developmental process regulation of developmental process hemopoiesis biological regulation cell development regulation of cell differentiation regulation of cell development multicellular organism development cell differentiation immune system process anatomical structure development regulation of hemopoiesis cellular process regulation of immune system process regulation of multicellular organismal process response to electrical stimulus response to stimulus response to abiotic stimulus cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process homeostatic process positive regulation of biological process positive regulation of developmental process positive regulation of cell differentiation myeloid cell homeostasis positive regulation of cellular process erythrocyte homeostasis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation positive regulation of myeloid cell differentiation homeostasis of number of cells response to immobilization stress response to stress transcription by RNA polymerase II regulation of transcription by RNA polymerase II erythrocyte development erythrocyte maturation developmental maturation anatomical structure maturation myeloid cell development cell maturation cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-containing complex catalytic complex histone H3-K14 acetyltransferase complex nuclear protein-containing complex chromatin chromosome transferase complex H3 histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex intracellular non-membrane-bounded organelle protein acetyltransferase complex intracellular protein-containing complex non-membrane-bounded organelle MOZ/MORF histone acetyltransferase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002515	Zinc finger, C2H2C-type	Repeat
A	IPR050603	MYST family histone acetyltransferases	Family
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A	IPR040706	MYST, zinc finger domain	Domain
A	IPR036060	Zinc finger, C2H2C-type superfamily	Homologous Superfamily
A	IPR002717	Histone acetyltransferase domain, MYST-type	Domain
B	IPR001965	Zinc finger, PHD-type	Domain
B	IPR018359	Bromodomain, conserved site	Conserved Site
B	IPR001487	Bromodomain	Domain
B	IPR000313	PWWP domain	Domain
B	IPR042009	BRPF2, PHD domain	Domain
B	IPR019787	Zinc finger, PHD-finger	Domain
B	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
B	IPR019542	Enhancer of polycomb-like, N-terminal	Domain
B	IPR019786	Zinc finger, PHD-type, conserved site	Conserved Site
B	IPR034732	Extended PHD (ePHD) domain	Domain
B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
B	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
B	IPR042004	BRPF2, ePHD domain	Domain
B	IPR050701	Histone Modification Regulator	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O95251	acute myeloid leukemia psoriasis congestive heart failure diabetes mellitus
B	Pharos: O95696	adenoid cystic carcinoma salivary gland adenoid cystic carcinoma osteosarcoma schizophrenia bipolar disorder ovarian cancer subependymal giant cell astrocytoma medulloblastoma tuberculosis