Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6nmma2 All alpha proteins Four-helical up-and-down bundle Nucleotidyltransferase substrate binding subunit/domain Kanamycin nucleotidyltransferase (KNTase), C-terminal domain automated matches Bacillus stearothermophilus (Geobacillus stearothermophilus ) [TaxId: 1422 ], SCOPe (2.08)
Ad6nmma1 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase Kanamycin nucleotidyltransferase (KNTase), N-terminal domain automated matches Bacillus stearothermophilus (Geobacillus stearothermophilus ) [TaxId: 1422 ], SCOPe (2.08)
Bd6nmmb2 All alpha proteins Four-helical up-and-down bundle Nucleotidyltransferase substrate binding subunit/domain Kanamycin nucleotidyltransferase (KNTase), C-terminal domain automated matches Bacillus stearothermophilus (Geobacillus stearothermophilus ) [TaxId: 1422 ], SCOPe (2.08)
Bd6nmmb1 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase Kanamycin nucleotidyltransferase (KNTase), N-terminal domain automated matches Bacillus stearothermophilus (Geobacillus stearothermophilus ) [TaxId: 1422 ], SCOPe (2.08)
Cd6nmmc2 All alpha proteins Four-helical up-and-down bundle Nucleotidyltransferase substrate binding subunit/domain Kanamycin nucleotidyltransferase (KNTase), C-terminal domain automated matches Bacillus stearothermophilus (Geobacillus stearothermophilus ) [TaxId: 1422 ], SCOPe (2.08)
Cd6nmmc1 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase Kanamycin nucleotidyltransferase (KNTase), N-terminal domain automated matches Bacillus stearothermophilus (Geobacillus stearothermophilus ) [TaxId: 1422 ], SCOPe (2.08)
Dd6nmmd2 All alpha proteins Four-helical up-and-down bundle Nucleotidyltransferase substrate binding subunit/domain Kanamycin nucleotidyltransferase (KNTase), C-terminal domain automated matches Bacillus stearothermophilus (Geobacillus stearothermophilus ) [TaxId: 1422 ], SCOPe (2.08)
Dd6nmmd1 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase Kanamycin nucleotidyltransferase (KNTase), N-terminal domain automated matches Bacillus stearothermophilus (Geobacillus stearothermophilus ) [TaxId: 1422 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AKNTase_Ce6nmmA2 A: alpha bundlesX: Four-helical up-and-down bundleH: HEPNT: Nucleotidyltransferase substrate binding subunit/domainF: KNTase_CECOD (1.6)
ANTP_transf_2e6nmmA1 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NTP_transf_2ECOD (1.6)
BKNTase_Ce6nmmB2 A: alpha bundlesX: Four-helical up-and-down bundleH: HEPNT: Nucleotidyltransferase substrate binding subunit/domainF: KNTase_CECOD (1.6)
BNTP_transf_2e6nmmB1 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NTP_transf_2ECOD (1.6)
CKNTase_Ce6nmmC1 A: alpha bundlesX: Four-helical up-and-down bundleH: HEPNT: Nucleotidyltransferase substrate binding subunit/domainF: KNTase_CECOD (1.6)
CNTP_transf_2e6nmmC2 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NTP_transf_2ECOD (1.6)
DKNTase_Ce6nmmD2 A: alpha bundlesX: Four-helical up-and-down bundleH: HEPNT: Nucleotidyltransferase substrate binding subunit/domainF: KNTase_CECOD (1.6)
DNTP_transf_2e6nmmD1 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NTP_transf_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B, C, D
ARO:3002623ANT(4')-IaANT(4')-Ia is a plasmid-encoded aminoglycoside nucleotidyltransferase in S. epidermidis, S. aureus, Enterococcus spp. and Bacillus spp.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B, C, D
ARO:3000229ANT(4')aminoglycoside antibioticantibiotic inactivationCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF07827KNTase C-terminal domain (KNTase_C)KNTase C-terminal domainKanamycin nucleotidyltransferase (KNTase) is involved in conferring resistance to aminoglycoside antibiotics and catalyses the transfer of a nucleoside monophosphate group from a nucleotide to kanamycin. This enzyme is dimeric with each subunit be ...Kanamycin nucleotidyltransferase (KNTase) is involved in conferring resistance to aminoglycoside antibiotics and catalyses the transfer of a nucleoside monophosphate group from a nucleotide to kanamycin. This enzyme is dimeric with each subunit being composed of two domains. The C-terminal domain contains five alpha helices, four of which are organised into an up-and-down alpha helical bundle. Residues found in this domain may contribute to this enzyme's active site [1].
Domain

InterPro: Protein Family Classification InterPro Database Homepage