Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AKNTase_Ce6nmnA1 A: alpha bundlesX: Four-helical up-and-down bundleH: HEPNT: Nucleotidyltransferase substrate binding subunit/domainF: KNTase_CECOD (1.6)
ANTP_transf_2e6nmnA2 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NTP_transf_2ECOD (1.6)
BKNTase_Ce6nmnB1 A: alpha bundlesX: Four-helical up-and-down bundleH: HEPNT: Nucleotidyltransferase substrate binding subunit/domainF: KNTase_CECOD (1.6)
BNTP_transf_2e6nmnB2 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NTP_transf_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B
ARO:3002623ANT(4')-IaANT(4')-Ia is a plasmid-encoded aminoglycoside nucleotidyltransferase in S. epidermidis, S. aureus, Enterococcus spp. and Bacillus spp.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B
ARO:3000229ANT(4')aminoglycoside antibioticantibiotic inactivationCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF07827KNTase C-terminal domain (KNTase_C)KNTase C-terminal domainKanamycin nucleotidyltransferase (KNTase) is involved in conferring resistance to aminoglycoside antibiotics and catalyses the transfer of a nucleoside monophosphate group from a nucleotide to kanamycin. This enzyme is dimeric with each subunit be ...Kanamycin nucleotidyltransferase (KNTase) is involved in conferring resistance to aminoglycoside antibiotics and catalyses the transfer of a nucleoside monophosphate group from a nucleotide to kanamycin. This enzyme is dimeric with each subunit being composed of two domains. The C-terminal domain contains five alpha helices, four of which are organised into an up-and-down alpha helical bundle. Residues found in this domain may contribute to this enzyme's active site [1].
Domain

InterPro: Protein Family Classification InterPro Database Homepage