6P3W
Crystal structure of the Cyclin A-CDK2-ORC1 complex
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d6p3wa_ | Alpha and beta proteins (a+b) | Protein kinase-like (PK-like) | Protein kinase-like (PK-like) | Protein kinases, catalytic subunit | Cyclin-dependent PK, CDK2 | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
D [auth C] | d6p3wc_ | Alpha and beta proteins (a+b) | Protein kinase-like (PK-like) | Protein kinase-like (PK-like) | Protein kinases, catalytic subunit | Cyclin-dependent PK, CDK2 | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d6p3wb1 | All alpha proteins | Cyclin-like | Cyclin-like | Cyclin | Cyclin A | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
E [auth D] | d6p3wd1 | All alpha proteins | Cyclin-like | Cyclin-like | Cyclin | Cyclin A | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Protein kinase-like (PK-like) | 8040310 | 3000066 | SCOP2B (2022-06-29) |
D [auth C] | SCOP2B Superfamily | Protein kinase-like (PK-like) | 8040310 | 3000066 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Cyclin-like | 8038665 | 3000768 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Cyclin-like | 8038664 | 3000768 | SCOP2B (2022-06-29) |
E [auth D] | SCOP2B Superfamily | Cyclin-like | 8038665 | 3000768 | SCOP2B (2022-06-29) |
E [auth D] | SCOP2B Superfamily | Cyclin-like | 8038664 | 3000768 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Pkinase_Tyr | e6p3wA1 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: Protein kinase | F: Pkinase_Tyr | ECOD (1.6) |
D [auth C] | Pkinase_Tyr | e6p3wC1 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: Protein kinase | F: Pkinase_Tyr | ECOD (1.6) |
B | Cyclin_C | e6p3wB1 | A: alpha arrays | X: HTH | H: HTH | T: Cyclin-like | F: Cyclin_C | ECOD (1.6) |
B | Cyclin_N | e6p3wB2 | A: alpha arrays | X: HTH | H: HTH | T: Cyclin-like | F: Cyclin_N | ECOD (1.6) |
E [auth D] | Cyclin_C | e6p3wD2 | A: alpha arrays | X: HTH | H: HTH | T: Cyclin-like | F: Cyclin_C | ECOD (1.6) |
E [auth D] | Cyclin_N | e6p3wD1 | A: alpha arrays | X: HTH | H: HTH | T: Cyclin-like | F: Cyclin_N | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 1.10.472.10 | Mainly Alpha | Orthogonal Bundle | Cyclin A | domain 1 | CATH (utative) |
E [auth D] | 1.10.472.10 | Mainly Alpha | Orthogonal Bundle | Cyclin A | domain 1 | CATH (utative) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, D [auth C] | PF00069 | Protein kinase domain (Pkinase) | Protein kinase domain | - | Domain |
B, E [auth D] | PF02984 | Cyclin, C-terminal domain (Cyclin_C) | Cyclin, C-terminal domain | Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain. | Domain |
B, E [auth D] | PF00134 | Cyclin, N-terminal domain (Cyclin_N) | Cyclin, N-terminal domain | Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain. | Domain |