Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyProtein kinase-like (PK-like) 8040310 3000066 SCOP2B (2022-06-29)
D [auth C]SCOP2B SuperfamilyProtein kinase-like (PK-like) 8040310 3000066 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCyclin-like 8038665 3000768 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCyclin-like 8038664 3000768 SCOP2B (2022-06-29)
E [auth D]SCOP2B SuperfamilyCyclin-like 8038665 3000768 SCOP2B (2022-06-29)
E [auth D]SCOP2B SuperfamilyCyclin-like 8038664 3000768 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APkinase_Tyre6p3wA1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
D [auth C]Pkinase_Tyre6p3wC1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
BCyclin_Ce6p3wB1 A: alpha arraysX: HTHH: HTHT: Cyclin-likeF: Cyclin_CECOD (1.6)
BCyclin_Ne6p3wB2 A: alpha arraysX: HTHH: HTHT: Cyclin-likeF: Cyclin_NECOD (1.6)
E [auth D]Cyclin_Ce6p3wD2 A: alpha arraysX: HTHH: HTHT: Cyclin-likeF: Cyclin_CECOD (1.6)
E [auth D]Cyclin_Ne6p3wD1 A: alpha arraysX: HTHH: HTHT: Cyclin-likeF: Cyclin_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
B1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A domain 1CATH (utative)
E [auth D]1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A domain 1CATH (utative)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
D [auth C]
PF00069Protein kinase domain (Pkinase)Protein kinase domain- Domain
B,
E [auth D]
PF02984Cyclin, C-terminal domain (Cyclin_C)Cyclin, C-terminal domainCyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.Domain
B,
E [auth D]
PF00134Cyclin, N-terminal domain (Cyclin_N)Cyclin, N-terminal domainCyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
D [auth C]
Cyclin-dependent kinase 2
B,
E [auth D]
Cyclin-A2
C [auth E],
F
ORC1 Peptide

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A,
D [auth C]
PharosP24941
B,
E [auth D]
PharosP20248
C [auth E],
F
PharosQ13415