6PYY

Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PF-06840003 in Active Site and Exo site

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8098710	3001961	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8098710	3001961	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8098710	3001961	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8098710	3001961	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Trp_dioxygenase	e6pyyA1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
C	Trp_dioxygenase	e6pyyC1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
D	Trp_dioxygenase	e6pyyD1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
B	Trp_dioxygenase	e6pyyB1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Tryptophan 2,3-dioxygenase	oxygen binding binding small molecule binding organic cyclic compound binding tetrapyrrole binding heme binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen tryptophan 2,3-dioxygenase activity oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity amino acid binding cation binding oxygen binding binding small molecule binding organic cyclic compound binding tetrapyrrole binding heme binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen tryptophan 2,3-dioxygenase activity oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity amino acid binding cation binding ion binding metal ion binding identical protein binding protein binding	response to stimulus response to chemical response to oxygen-containing compound response to nitroglycerin response to nitrogen compound catabolic process oxoacid metabolic process aromatic amino acid family catabolic process indole-containing compound metabolic process amino acid metabolic process organic acid catabolic process organic acid metabolic process alpha-amino acid metabolic process cellular catabolic process response to stimulus response to chemical response to oxygen-containing compound response to nitroglycerin response to nitrogen compound catabolic process oxoacid metabolic process aromatic amino acid family catabolic process indole-containing compound metabolic process amino acid metabolic process organic acid catabolic process organic acid metabolic process alpha-amino acid metabolic process cellular catabolic process non-proteinogenic amino acid metabolic process cellular ketone metabolic process carboxylic acid catabolic process indolalkylamine metabolic process small molecule metabolic process amino acid catabolic process aromatic amino acid metabolic process benzene-containing compound metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process amine metabolic process kynurenine metabolic process tryptophan catabolic process to kynurenine alpha-amino acid catabolic process indole-containing compound catabolic process tryptophan catabolic process metabolic process cellular process small molecule catabolic process biogenic amine metabolic process protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis acetyl-CoA metabolic process nucleobase-containing compound metabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process amide catabolic process phosphate-containing compound metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process purine-containing compound metabolic process organophosphate metabolic process tryptophan catabolic process to acetyl-CoA	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR037217	Tryptophan/Indoleamine 2,3-dioxygenase-like	Homologous Superfamily
A, B, C, D	IPR004981	Tryptophan 2,3-dioxygenase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P48775	Starvation familial hypertryptophanemia pancreatic ductal adenocarcinoma primitive neuroectodermal tumor schizophrenia amyotrophic lateral sclerosis spina bifida breast carcinoma ductal breast carcinoma in situ head and neck cancer lung adenocarcinoma medulloblastoma oligodendroglioma periodontitis psoriasis Starvation familial hypertryptophanemia pancreatic ductal adenocarcinoma primitive neuroectodermal tumor schizophrenia amyotrophic lateral sclerosis spina bifida breast carcinoma ductal breast carcinoma in situ head and neck cancer lung adenocarcinoma medulloblastoma oligodendroglioma periodontitis psoriasis astrocytic tumor bipolar disorder chronic obstructive pulmonary disease interstitial cystitis major depressive disorder non-small cell lung carcinoma ovarian cancer pituitary cancer Sjogren syndrome autism ulcerative colitis breast cancer cutaneous lupus erythematosus gastric carcinoma invasive ductal breast carcinoma malignant mesothelioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.