Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6r2ea_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth C]d6r2ec_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
C [auth D]d6r2ed_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
D [auth B]d6r2eb_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
E [auth F]d6r2ef_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
F [auth H]d6r2eh_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
G [auth E]d6r2ee_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
H [auth G]d6r2eg_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
B [auth C]SCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
C [auth D]SCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
D [auth B]SCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
E [auth F]SCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
F [auth H]SCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
G [auth E]SCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)
H [auth G]SCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8036156 3000544 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AThymidylat_synte6r2eA1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
B [auth C]Thymidylat_synte6r2eC1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
C [auth D]Thymidylat_synte6r2eD1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
D [auth B]Thymidylat_synte6r2eB1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
E [auth F]Thymidylat_synte6r2eF1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
F [auth H]Thymidylat_synte6r2eH1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
G [auth E]Thymidylat_synte6r2eE1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
H [auth G]Thymidylat_synte6r2eG1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00303Thymidylate synthase (Thymidylat_synt)Thymidylate synthaseThis is a family of proteins that are flavin-dependent thymidylate synthases.Domain
G [auth E],
H [auth G]
PF00303Thymidylate synthase (Thymidylat_synt)Thymidylate synthaseThis is a family of proteins that are flavin-dependent thymidylate synthases.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Thymidylate synthase
G [auth E],
H [auth G]
Thymidylate synthase

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP04818
G [auth E],
H [auth G]
PharosP04818

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
CME Parent Component: CYS

G [auth E],
H [auth G]
CME Parent Component: CYS

G [auth E],
H [auth G]
SCH Parent Component: CYS

RESIDAA0101

PSI-MOD :  L-cysteine methyl disulfide MOD:00110