6R2E
Crystal structure of the human thymidylate synthase (hTS) interface variant Q62R
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
- Protein Modification Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
B [auth C] | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
C [auth D] | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
D [auth B] | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
E [auth F] | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
F [auth H] | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
G [auth E] | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
H [auth G] | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8036156 | 3000544 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Thymidylat_synt | e6r2eA1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
B [auth C] | Thymidylat_synt | e6r2eC1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
C [auth D] | Thymidylat_synt | e6r2eD1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
D [auth B] | Thymidylat_synt | e6r2eB1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
E [auth F] | Thymidylat_synt | e6r2eF1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
F [auth H] | Thymidylat_synt | e6r2eH1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
G [auth E] | Thymidylat_synt | e6r2eE1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
H [auth G] | Thymidylat_synt | e6r2eG1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
B [auth C] | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
C [auth D] | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
D [auth B] | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
E [auth F] | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
F [auth H] | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
G [auth E] | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
H [auth G] | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (utative) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00303 | Thymidylate synthase (Thymidylat_synt) | Thymidylate synthase | This is a family of proteins that are flavin-dependent thymidylate synthases. | Domain | |
G [auth E], H [auth G] | PF00303 | Thymidylate synthase (Thymidylat_synt) | Thymidylate synthase | This is a family of proteins that are flavin-dependent thymidylate synthases. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Pharos: Disease Associations Pharos Homepage Annotation
Protein Modification Annotation
Modified Residue(s) | ||
---|---|---|
Chain | Residue(s) | Description |
CME | Parent Component: CYS | |
G [auth E], H [auth G] | CME | Parent Component: CYS |
G [auth E], H [auth G] | SCH | Parent Component: CYS :  AA0101 :  L-cysteine methyl disulfide MOD:00110 |