6S0L

Structure of the A2A adenosine receptor determined at SwissFEL using native-SAD at 4.57 keV from all available diffraction patterns

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091190	3000473	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_3	e6s0lA2	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_3	ECOD (1.6)
A	Cytochrom_B562_1	e6s0lA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Cytochromes (From Topology)	T: Cytochromes	F: Cytochrom_B562_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	A2a adenosine receptor	molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity G protein-coupled adenosine receptor activity protein-containing complex binding binding protein binding calmodulin binding identical protein binding cytoskeletal protein binding alpha-actinin binding actinin binding lipid binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity G protein-coupled adenosine receptor activity protein-containing complex binding binding protein binding calmodulin binding identical protein binding cytoskeletal protein binding alpha-actinin binding actinin binding lipid binding type 5 metabotropic glutamate receptor binding signaling receptor binding glutamate receptor binding G protein-coupled receptor binding G protein-coupled glutamate receptor binding enzyme binding	response to stimulus response to chemical response to xenobiotic stimulus multicellular organismal process regulation of body fluid levels wound healing hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of cellular process response to stimulus response to chemical response to xenobiotic stimulus multicellular organismal process regulation of body fluid levels wound healing hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of cellular process regulation of alpha-beta T cell activation regulation of leukocyte activation negative regulation of biological process regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation leukocyte cell-cell adhesion negative regulation of cell adhesion leukocyte activation cell adhesion cell-cell adhesion T cell activation negative regulation of cellular process alpha-beta T cell activation regulation of multicellular organismal process regulation of immune system process regulation of cell-cell adhesion regulation of biological process regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation negative regulation of T cell activation negative regulation of immune system process negative regulation of leukocyte cell-cell adhesion immune system process negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion cellular process negative regulation of alpha-beta T cell activation negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of lymphocyte activation developmental process multicellular organism development central nervous system development anatomical structure development nervous system development system development trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission signaling cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of apoptotic signaling pathway positive regulation of response to stimulus signal transduction positive regulation of cellular process positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus apoptotic process programmed cell death positive regulation of signaling regulation of apoptotic signaling pathway regulation of calcium ion transport regulation of localization transport regulation of transport regulation of monoatomic ion transport establishment of localization metal ion transport calcium ion transport localization monoatomic ion transport regulation of metal ion transport monoatomic cation transport import into cell phagocytosis endocytosis vesicle-mediated transport response to nitrogen compound response to purine-containing compound response to organic cyclic compound response to caffeine response to alkaloid purinergic nucleotide receptor signaling pathway cell surface receptor signaling pathway G protein-coupled purinergic receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled adenosine receptor signaling pathway system process sensory perception nervous system process negative regulation of vascular permeability regulation of vascular permeability circulatory system process vascular process in circulatory system blood circulation startle response regulation of response to external stimulus neuromuscular process negative regulation of response to stimulus prepulse inhibition response to external stimulus negative regulation of response to external stimulus nitrogen compound transport positive regulation of neurotransmitter secretion positive regulation of amine transport acetylcholine secretion, neurotransmission establishment of localization in cell positive regulation of acetylcholine secretion, neurotransmission positive regulation of neurotransmitter transport positive regulation of synaptic transmission, cholinergic neurotransmitter secretion positive regulation of synaptic transmission regulation of acetylcholine secretion, neurotransmission neurotransmitter transport organic cation transport acetate ester transport regulation of secretion signal release from synapse acetylcholine transport cellular localization positive regulation of secretion by cell regulation of secretion by cell secretion by cell positive regulation of secretion signal release acetylcholine secretion secretion regulation of neurotransmitter transport export from cell amine transport positive regulation of transport regulation of neurotransmitter secretion synaptic transmission, cholinergic regulation of amine transport regulation of synaptic transmission, cholinergic cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process cellular developmental process astrocyte differentiation cell development astrocyte activation glial cell development neurogenesis astrocyte development gliogenesis cell differentiation defense response glial cell differentiation glial cell activation inflammatory response neuroinflammatory response synaptic transmission, dopaminergic regulation of postsynaptic membrane potential chemical synaptic transmission, postsynaptic inhibitory postsynaptic potential regulation of membrane potential cellular defense response behavior locomotory behavior long-term synaptic potentiation positive regulation of long-term synaptic potentiation regulation of synaptic plasticity regulation of long-term synaptic potentiation synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic positive regulation of synaptic transmission, glutamatergic regulation of mitochondrial membrane potential positive regulation of synaptic transmission, GABAergic synaptic transmission, GABAergic regulation of synaptic transmission, GABAergic regulation of defense response negative regulation of inflammatory response regulation of inflammatory response regulation of response to stress negative regulation of defense response renal system process positive regulation of urine volume regulation of urine volume eating behavior feeding behavior adenylate cyclase-modulating G protein-coupled receptor signaling pathway rhythmic process circadian sleep/wake cycle, sleep circadian sleep/wake cycle rhythmic behavior regulation of circadian sleep/wake cycle circadian rhythm regulation of circadian rhythm regulation of behavior circadian behavior positive regulation of behavior positive regulation of circadian rhythm positive regulation of multicellular organismal process sleep positive regulation of circadian sleep/wake cycle, sleep regulation of circadian sleep/wake cycle, sleep circadian sleep/wake cycle process monoamine transport regulation of catecholamine secretion organic hydroxy compound transport catecholamine transport norepinephrine transport catecholamine secretion norepinephrine secretion regulation of norepinephrine secretion neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death negative regulation of apoptotic process regulation of neuron apoptotic process cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis cellular component organization cell projection morphogenesis neuron differentiation neuron projection morphogenesis cellular component organization or biogenesis plasma membrane bounded cell projection organization generation of neurons anatomical structure morphogenesis neuron development adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of tube diameter regulation of tube size blood vessel diameter maintenance vasodilation regulation of anatomical structure size excitatory postsynaptic potential protein localization establishment of protein localization regulation of protein localization positive regulation of establishment of protein localization protein localization to extracellular region positive regulation of protein transport cellular macromolecule localization regulation of establishment of protein localization establishment of protein localization to extracellular region regulation of protein transport protein secretion positive regulation of protein secretion regulation of protein secretion protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation response to amine response to amphetamine membrane depolarization regulation of glutamate secretion regulation of amino acid transport glutamate secretion organic anion transport carboxylic acid transport positive regulation of glutamate secretion positive regulation of organic acid transport organic acid transport amino acid transport acidic amino acid transport positive regulation of amino acid transport regulation of organic acid transport dicarboxylic acid transport	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane presynapse presynaptic active zone presynaptic membrane somatodendritic compartment cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane presynapse presynaptic active zone presynaptic membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection glutamatergic synapse axon cell leading edge axolemma leading edge membrane neuron projection membrane main axon cell projection membrane cell body neuronal cell body polymeric cytoskeletal fiber intracellular anatomical structure intermediate filament cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle intermediate filament supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle neuron to neuron synapse asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001634	Adenosine receptor	Family
A	IPR001513	Adenosine A2A receptor	Family
A	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A	IPR017452	GPCR, rhodopsin-like, 7TM	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P29274	cardiomyopathy rheumatoid arthritis Sepsis panic disorder amphetamine abuse Parkinson disease substance withdrawal syndrome drug allergy visual epilepsy melancholia endogenous depression bronchitis heart disease common cold lung disease cardiomyopathy rheumatoid arthritis Sepsis panic disorder amphetamine abuse Parkinson disease substance withdrawal syndrome drug allergy visual epilepsy melancholia endogenous depression bronchitis heart disease common cold lung disease migraine disorder anxiety disorder inherited disease susceptibility acne pulmonary emphysema neurotic disorder hypotensive disorder insomnia ischemia reperfusion injury allergic rhinitis depressive disorder drug psychosis movement disorder schizophrenia asthma

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.