Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
DC1-set_2e6ss7D2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
DMHC_Ie6ss7D1 A: a+b two layersX: MHC antigen-recognition domain (From Topology)H: MHC antigen-recognition domain (From Topology)T: MHC antigen-recognition domainF: MHC_IECOD (1.6)
AC1-set_2e6ss7A2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
AMHC_Ie6ss7A1 A: a+b two layersX: MHC antigen-recognition domain (From Topology)H: MHC antigen-recognition domain (From Topology)T: MHC antigen-recognition domainF: MHC_IECOD (1.6)
BC1-set_2e6ss7B1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
EC1-set_2e6ss7E1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
A, D
MH1 HLA-A*0201 I-ALPHA Homo sapiens (human) HLA-A*0201, HLA-A*0203, HLA-A*0204, HLA-A*0207, HLA-A*0209, HLA-A*0212, HLA-A*0213, HLA-A*0216, HLA-A*0217, HLA-A*0218, HLA-A*0222, HLA-A*0224, HLA-A*0226, HLA-A*0233, HLA-A*0266, HLA-A*0289, HLA-A*0268, HLA-A*0265, HLA-A*0277, HLA-A*0260, HLA-A*9232, HLA-A*9234, HLA-A*9235 G-DOMAIN G-ALPHA1, G-DOMAIN G-ALPHA2, C-LIKE-DOMAIN C-LIKE MH MH1-ALPHA_B2M IMGT (202449-0)
B, E
MH1 HLA-A*0201 B2M Homo sapiens (human) B2M*01, B2M*02 C-LIKE-DOMAIN C-LIKE MH MH1-ALPHA_B2M IMGT (202449-0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, D
PF00129Class I Histocompatibility antigen, domains alpha 1 and 2 (MHC_I)Class I Histocompatibility antigen, domains alpha 1 and 2- Domain
A, D
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
B, E
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, D
HLA class I histocompatibility antigen, A-2 alpha chain
B, E
Beta-2-microglobulin
C, F
LEU-LEU-TRP-ALA-GLY-PRO-MET-ALA-VAL

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, D
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
A, D
IPR010579MHC class I, alpha chain, C-terminalDomain
A, D
IPR011162MHC classes I/II-like antigen recognition proteinHomologous Superfamily
A, D
IPR001039MHC class I alpha chain, alpha1 alpha2 domainsDomain
A, D
IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
A, D
IPR013783Immunoglobulin-like foldHomologous Superfamily
A, D
IPR007110Immunoglobulin-like domainDomain
A, D
IPR050208Antigen-presenting and immune regulatory MHC class I-relatedFamily
A, D
IPR003597Immunoglobulin C1-setDomain
A, D
IPR011161MHC class I-like antigen recognition-likeDomain
A, D
IPR037055MHC class I-like antigen recognition-like superfamilyHomologous Superfamily
B, E
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
B, E
IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
B, E
IPR013783Immunoglobulin-like foldHomologous Superfamily
B, E
IPR007110Immunoglobulin-like domainDomain
B, E
IPR050160Major Histocompatibility Complex/ImmunoglobulinFamily
B, E
IPR003597Immunoglobulin C1-setDomain
B, E
IPR015707Beta-2-MicroglobulinFamily
C, F
IPR000208RNA-directed RNA polymerase, fingers/palm subdomains, flavivirusDomain
C, F
IPR014756Immunoglobulin E-setHomologous Superfamily
C, F
IPR001122Capsid protein C, flavivirusDomain
C, F
IPR027287Glycoprotein E, immunoglobulin-like domain, flavivirusDomain
C, F
IPR014412Genome polyprotein, FlavivirusFamily
C, F
IPR036253Flavivirus glycoprotein, central and dimerisation domain superfamilyHomologous Superfamily
C, F
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
C, F
IPR026490mRNA cap 0/1 methyltransferaseDomain
C, F
IPR009003Peptidase S1, PA clanHomologous Superfamily
C, F
IPR001650Helicase, C-terminal domain-likeDomain
C, F
IPR014001Helicase superfamily 1/2, ATP-binding domainDomain
C, F
IPR013755Flaviviral glycoprotein E, central domain, subdomain 1Homologous Superfamily
C, F
IPR000752Flavivirus non-structural protein NS2ADomain
C, F
IPR047530RNA-dependent RNA polymerase, flavivirusDomain
C, F
IPR049486Flavivridae NS3 helicase, C-terminal helical domainDomain
C, F
IPR046811RNA-directed RNA polymerase, thumb subdomain, flavivirusDomain
C, F
IPR038055Flaviviral glycoprotein E, dimerisation domainHomologous Superfamily
C, F
IPR002877Ribosomal RNA methyltransferase, FtsJ domainDomain
C, F
IPR038302Envelope glycoprotein M superfamily, flavivirusHomologous Superfamily
C, F
IPR000069Envelope glycoprotein M, flavivirusDomain
C, F
IPR011492Non-structural protein NS3-like, DEAD box helicase, flavivirusDomain
C, F
IPR038345Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamilyHomologous Superfamily
C, F
IPR038688Flavivirus polyprotein propeptide superfamilyHomologous Superfamily
C, F
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
C, F
IPR026470Flavivirus envelope glycoprotein E, Stem/Anchor domainDomain
C, F
IPR011998Envelope glycoprotein E, central and dimerisation domain, flavivirusDomain
C, F
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
C, F
IPR037172Flavivirus capsid protein C superfamilyHomologous Superfamily
C, F
IPR000404Flavivirus non-structural protein NS4ADomain
C, F
IPR000487Non-structural protein NS2B, flavivirusDomain
C, F
IPR001528Flavivirus non-structural protein NS4BDomain
C, F
IPR001157Non-structural protein NS1, flavivirusDomain
C, F
IPR013756Flaviviral glycoprotein E, central domain, subdomain 2Homologous Superfamily
C, F
IPR001850Non-structural protein NS3, peptidase S7, flavivirusDomain
C, F
IPR000336Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamilyHomologous Superfamily
C, F
IPR002535Flavivirus polyprotein propeptideDomain
C, F
IPR007094RNA-directed RNA polymerase, catalytic domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, D
PharosP04439
B, E
PharosP61769