Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6t0xa1 All beta proteins PUA domain-like PUA domain-like automated matches automated matches (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad6t0xa2 Artifacts Tags Tags Tags N-terminal Tags (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd6t0xb1 All beta proteins PUA domain-like PUA domain-like automated matches automated matches (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd6t0xb2 Artifacts Tags Tags Tags N-terminal Tags (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyPUA domain-like 8090679 3001015 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPUA domain-like 8090679 3001015 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AYTHe6t0xA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PUA domainF: YTHECOD (1.6)
BYTHe6t0xB1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PUA domainF: YTHECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.10.590.10 Alpha Beta Roll ph1033 like fold ph1033 like domainsCATH (utative)
B3.10.590.10 Alpha Beta Roll ph1033 like fold ph1033 like domainsCATH (utative)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF04146YT521-B-like domain (YTH)YT521-B-like domainA protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells [3]. It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppr ...A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells [3]. It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing. The rat protein Swiss:Q9QY02 YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner [1]. The YTH domain has been identified as part of the PUA superfamily [4].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
YTHDC1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR007275YTH domainDomain
A, B
IPR045168YTH domain containing proteinFamily