6TNH

Deoxyguanylosuccinate synthase (DgsS) quaternary structure with AMPPcP, dGMP, Asp, Magnesium at 2.21 Angstrom resolution

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Adenylsucc_synt	e6tnhA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Adenylsucc_synt	ECOD (1.6)
B	Adenylsucc_synt	e6tnhB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Adenylsucc_synt	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00709	Adenylosuccinate synthetase (Adenylsucc_synt)	Adenylosuccinate synthetase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Adenylosuccinate synthetase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding adenylosuccinate synthase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity	IMP metabolic process nucleoside phosphate metabolic process ribose phosphate metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine nucleoside monophosphate metabolic process IMP metabolic process nucleoside phosphate metabolic process ribose phosphate metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process purine ribonucleotide metabolic process phosphorus metabolic process nucleoside monophosphate metabolic process nucleotide biosynthetic process nucleobase-containing compound biosynthetic process biosynthetic process organophosphate biosynthetic process purine-containing compound biosynthetic process nucleoside phosphate biosynthetic process purine nucleotide biosynthetic process 'de novo' AMP biosynthetic process purine ribonucleoside monophosphate biosynthetic process purine ribonucleotide biosynthetic process AMP metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process ribose phosphate biosynthetic process carbohydrate derivative biosynthetic process nucleoside monophosphate biosynthetic process AMP biosynthetic process ribonucleoside monophosphate biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001114	Adenylosuccinate synthetase	Family
A, B	IPR046383	N6-succino-2-amino-2'-deoxyadenylate synthase	Family
A, B	IPR042109	Adenylosuccinate synthetase, domain 1	Homologous Superfamily
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.