6U7F
HCoV-229E RBD Class IV in complex with human APN
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | ERAP1, insert domain | 8054110 | 3002272 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Metalloproteases (zincins), catalytic domain | 8054109 | 3001975 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Leukotriene A4 hydrolase N-terminal domain | 8054108 | 3000390 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | ARM repeat-like | 8054111 | 3000116 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Metalloproteases (zincins), catalytic domain | 8054109 | 3001975 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | ERAP1, insert domain | 8054110 | 3002272 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | ARM repeat-like | 8054111 | 3000116 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Leukotriene A4 hydrolase N-terminal domain | 8054108 | 3000390 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | SARS coronavirus receptor-binding domain-like | 8093788 | 3001706 | SCOP2B (2022-06-29) |
D | SCOP2 Family | HCov-NL63 receptor-binding domain-like | 8093787 | 4006418 | SCOP2 (2022-06-29) |
D | SCOP2 Superfamily | SARS coronavirus receptor-binding domain-like | 8093788 | 3001706 | SCOP2 (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | ERAP1_C | e6u7fA1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: ERAP1_C | ECOD (1.6) |
A | Peptidase_M1_2 | e6u7fA2 | A: beta sandwiches | X: Baculovirus p35 protein-related (From Topology) | H: Baculovirus p35 protein-related (From Topology) | T: Baculovirus p35 protein-related | F: Peptidase_M1_2 | ECOD (1.6) |
A | ERAP1_C | e6u7fA3 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: ERAP1_C | ECOD (1.6) |
A | Peptidase_M1 | e6u7fA4 | A: mixed a+b and a/b | X: Zincin-like | H: Metalloproteases (zincins) catalytic domain (From Topology) | T: Metalloproteases (zincins) catalytic domain | F: Peptidase_M1 | ECOD (1.6) |
B | ERAP1_C | e6u7fB2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: ERAP1_C | ECOD (1.6) |
B | Peptidase_M1_2 | e6u7fB4 | A: beta sandwiches | X: Baculovirus p35 protein-related (From Topology) | H: Baculovirus p35 protein-related (From Topology) | T: Baculovirus p35 protein-related | F: Peptidase_M1_2 | ECOD (1.6) |
B | ERAP1_C | e6u7fB1 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: ERAP1_C | ECOD (1.6) |
B | Peptidase_M1 | e6u7fB3 | A: mixed a+b and a/b | X: Zincin-like | H: Metalloproteases (zincins) catalytic domain (From Topology) | T: Metalloproteases (zincins) catalytic domain | F: Peptidase_M1 | ECOD (1.6) |
C | Corona_S1_2nd | e6u7fC1 | A: a+b three layers | X: Coronavirus spike protein receptor-binding domain (From Homology) | H: Coronavirus spike protein receptor-binding domain | T: Alpha-coronavirus spike protein receptor-binding domain | F: Corona_S1_2nd | ECOD (1.6) |
D | Corona_S1_2nd | e6u7fD1 | A: a+b three layers | X: Coronavirus spike protein receptor-binding domain (From Homology) | H: Coronavirus spike protein receptor-binding domain | T: Alpha-coronavirus spike protein receptor-binding domain | F: Corona_S1_2nd | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.60.40.1730 | Mainly Beta | Sandwich | Immunoglobulin-like | tricorn interacting facor f3 domain | CATH (utative) |
A | 1.10.390.10 | Mainly Alpha | Orthogonal Bundle | Neutral Protease | domain 2 | CATH (utative) |
A | 2.60.40.1910 | Mainly Beta | Sandwich | Immunoglobulin-like | CATH (utative) | |
A | 1.25.50.20 | Mainly Alpha | Alpha Horseshoe | Zincin-like fold | CATH (utative) | |
B | 2.60.40.1730 | Mainly Beta | Sandwich | Immunoglobulin-like | tricorn interacting facor f3 domain | CATH (utative) |
B | 1.10.390.10 | Mainly Alpha | Orthogonal Bundle | Neutral Protease | domain 2 | CATH (utative) |
B | 2.60.40.1910 | Mainly Beta | Sandwich | Immunoglobulin-like | CATH (utative) | |
B | 1.25.50.20 | Mainly Alpha | Alpha Horseshoe | Zincin-like fold | CATH (utative) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF11838 | ERAP1-like C-terminal domain (ERAP1_C) | ERAP1-like C-terminal domain | This large domain is composed of 16 alpha helices organized as 8 HEAT-like repeats. This domain forms a concave face that faces towards the active site of the peptidase. | Domain | |
PF01433 | Peptidase family M1 domain (Peptidase_M1) | Peptidase family M1 domain | Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase Swiss:P09960, this enzyme also has an aminopeptidase activ ... | Domain | |
PF17900 | Peptidase M1 N-terminal domain (Peptidase_M1_N) | Peptidase M1 N-terminal domain | This domain is found at the N-terminus of aminopeptidases from the M1 family. | Domain | |