6WYK

Cryo-EM structure of the GltPh L152C-G321C mutant in the intermediate chloride conducting state.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Proton glutamate symport protein	8043308	3001772	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SDF	e6wykA1	A: alpha complex topology	X: Proton glutamate symport protein (From Topology)	H: Proton glutamate symport protein (From Topology)	T: Proton glutamate symport protein	F: SDF	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00375	Sodium:dicarboxylate symporter family (SDF)	Sodium:dicarboxylate symporter family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Glutamate transporter homolog	monoatomic cation transmembrane transporter activity amino acid:sodium symporter activity solute:sodium symporter activity solute:monoatomic cation symporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity active monoatomic ion transmembrane transporter activity amino acid transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity amino acid:monoatomic cation symporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity monoatomic cation transmembrane transporter activity amino acid:sodium symporter activity solute:sodium symporter activity solute:monoatomic cation symporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity active monoatomic ion transmembrane transporter activity amino acid transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity amino acid:monoatomic cation symporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity symporter activity L-amino acid transmembrane transporter activity L-aspartate transmembrane transporter activity carboxylic acid transmembrane transporter activity C4-dicarboxylate transmembrane transporter activity dicarboxylic acid transmembrane transporter activity acidic amino acid transmembrane transporter activity organic acid transmembrane transporter activity organic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic anion transmembrane transporter activity inorganic anion transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport cellular process inorganic anion transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport cellular process inorganic anion transport protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport aspartate transmembrane transport amino acid transmembrane transport L-amino acid transport C4-dicarboxylate transport organic acid transport amino acid transport dicarboxylic acid transport L-alpha-amino acid transmembrane transport L-aspartate transmembrane transport import into cell import across plasma membrane amino acid import across plasma membrane L-aspartate import across plasma membrane	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001991	Sodium:dicarboxylate symporter	Family
A	IPR018107	Sodium:dicarboxylate symporter, conserved site	Conserved Site
A	IPR036458	Sodium:dicarboxylate symporter superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	Dicarboxylate/amino acid:Cation Symporter (DAACS)	Proton glutamate symport protein

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Amino Acid Secondary Transporters	Glutamate Transporter Homologue (Glt_Ph), V216C-A391C mutant cross-linked in outward-facing state

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.