Annotations: 6X3A

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	fn3	e6x3aA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00041	Fibronectin type III domain (fn3)	Fibronectin type III domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Receptor-type tyrosine-protein phosphatase delta	protein binding binding signaling receptor binding phosphoric ester hydrolase activity molecular transducer activity catalytic activity, acting on a protein phosphatase activity signaling receptor activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity transmembrane receptor protein phosphatase activity transmembrane signaling receptor activity protein binding binding signaling receptor binding phosphoric ester hydrolase activity molecular transducer activity catalytic activity, acting on a protein phosphatase activity signaling receptor activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity transmembrane receptor protein phosphatase activity transmembrane signaling receptor activity transmembrane receptor protein tyrosine phosphatase activity catalytic activity cell adhesion molecule binding	positive regulation of nervous system development multicellular organismal process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of nervous system development positive regulation of developmental process cellular component organization cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly anatomical structure development positive regulation of nervous system development multicellular organismal process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of nervous system development positive regulation of developmental process cellular component organization cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly anatomical structure development regulation of multicellular organismal process regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of synapse assembly regulation of biological quality positive regulation of cellular process system development developmental process regulation of multicellular organismal development regulation of biological process positive regulation of cellular component biogenesis biological regulation nervous system development regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly regulation of synapse organization cell junction organization positive regulation of multicellular organismal process cellular process synapse assembly positive regulation of synapse assembly membrane organization presynapse organization membrane biogenesis presynaptic membrane assembly membrane assembly presynaptic membrane organization presynapse assembly cell adhesion cell-cell adhesion synaptic membrane adhesion cell-cell adhesion via plasma-membrane adhesion molecules response to stimulus regulation of response to stimulus immune response immune system process regulation of immune response regulation of immune system process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cellular developmental process generation of neurons neurogenesis neuron differentiation cell differentiation trans-synaptic signaling synaptic signaling trans-synaptic signaling by trans-synaptic complex signaling cell-cell signaling cell communication cellular response to stimulus cell surface receptor signaling pathway via STAT negative regulation of signaling negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of cellular process regulation of receptor signaling pathway via JAK-STAT signal transduction negative regulation of receptor signaling pathway via JAK-STAT regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of cell communication negative regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT modulation of chemical synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of postsynaptic specialization assembly regulation of excitatory synapse assembly postsynaptic density organization regulation of postsynaptic density organization postsynapse organization organelle assembly postsynaptic specialization assembly postsynapse assembly regulation of postsynapse organization regulation of organelle organization excitatory synapse assembly organelle organization regulation of organelle assembly postsynaptic specialization organization postsynaptic density assembly regulation of postsynaptic density assembly cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process cell surface receptor protein tyrosine phosphatase signaling pathway enzyme-linked receptor protein signaling pathway positive regulation of dendritic spine morphogenesis cell projection organization positive regulation of dendritic spine development regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell morphogenesis regulation of cell development cell projection morphogenesis neuron projection morphogenesis regulation of dendrite morphogenesis positive regulation of cell projection organization dendritic spine morphogenesis dendritic spine development dendritic spine organization regulation of cell projection organization positive regulation of cell development positive regulation of cell morphogenesis regulation of dendrite development regulation of neuron projection development plasma membrane bounded cell projection morphogenesis cell development regulation of dendritic spine development cell morphogenesis dendrite development positive regulation of neuron projection development positive regulation of cell differentiation positive regulation of neurogenesis regulation of anatomical structure morphogenesis plasma membrane bounded cell projection organization dendrite morphogenesis positive regulation of dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron development regulation of dendritic spine morphogenesis neuron projection organization regulation of plasma membrane bounded cell projection organization	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane presynapse extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane presynapse synapse cell junction presynaptic membrane plasma membrane region synaptic membrane glutamatergic synapse neuron to neuron synapse hippocampal mossy fiber to CA3 synapse Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR003598	Immunoglobulin subtype 2	Domain
A	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
A	IPR003599	Immunoglobulin domain subtype	Domain
A	IPR013098	Immunoglobulin I-set	Domain
A	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A	IPR050713	Receptor-type Tyrosine-protein Phosphatases/Ushers	Family
A	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A	IPR003961	Fibronectin type III	Domain
A	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain	Domain
A	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR045905	Receptor-type tyrosine-protein phosphatase delta, PTPase domain, repeat 1	Domain
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P23468	restless legs syndrome breast carcinoma colorectal cancer breast cancer Liver Cirrhosis, Experimental malignant colon neoplasm malignant mesothelioma acute myeloid leukemia ovarian cancer attention deficit hyperactivity disorder, inattentive type psoriasis type 2 diabetes mellitus facioscapulohumeral muscular dystrophy interstitial cystitis lung adenocarcinoma restless legs syndrome breast carcinoma colorectal cancer breast cancer Liver Cirrhosis, Experimental malignant colon neoplasm malignant mesothelioma acute myeloid leukemia ovarian cancer attention deficit hyperactivity disorder, inattentive type psoriasis type 2 diabetes mellitus facioscapulohumeral muscular dystrophy interstitial cystitis lung adenocarcinoma malignant ependymoma maturity-onset diabetes of the young non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor ulcerative colitis Down syndrome glioblastoma large cell medulloblastoma lung cancer malignant glioma medulloblastoma osteosarcoma pituitary cancer subependymal giant cell astrocytoma colorectal carcinoma Emery-Dreifuss muscular dystrophy hydrolethalus syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.