6Y02

Thrombin in complex with 13k

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
B [auth H]SCOP2B SuperfamilyTrypsin-like serine proteases 8042154 3000114 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
B [auth H]Trypsine6y02H1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrel 2F: TrypsinECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B [auth H]PF00089Trypsin (Trypsin)Trypsin- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth L]Prothrombin
B [auth H]Prothrombin
Hirudin variant-2 -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth L]IPR018992Thrombin light chainDomain
A [auth L]IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
A [auth L]IPR003966Prothrombin/thrombinFamily
A [auth L]IPR018114Serine proteases, trypsin family, histidine active siteActive Site
A [auth L]IPR009003Peptidase S1, PA clanHomologous Superfamily
A [auth L]IPR033116Serine proteases, trypsin family, serine active siteActive Site
A [auth L]IPR001254Serine proteases, trypsin domainDomain
A [auth L]IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
A [auth L]IPR000001KringleDomain
A [auth L]IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
A [auth L]IPR051659Serine Protease S1 Domain-Containing ProteinFamily
A [auth L]IPR018056Kringle, conserved siteConserved Site
A [auth L]IPR013806Kringle-like foldHomologous Superfamily
A [auth L]IPR038178Kringle superfamilyHomologous Superfamily
A [auth L]IPR001314Peptidase S1A, chymotrypsin familyFamily
A [auth L]IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
B [auth H]IPR018992Thrombin light chainDomain
B [auth H]IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
B [auth H]IPR003966Prothrombin/thrombinFamily
B [auth H]IPR018114Serine proteases, trypsin family, histidine active siteActive Site
B [auth H]IPR009003Peptidase S1, PA clanHomologous Superfamily
B [auth H]IPR033116Serine proteases, trypsin family, serine active siteActive Site
B [auth H]IPR001254Serine proteases, trypsin domainDomain
B [auth H]IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
B [auth H]IPR000001KringleDomain
B [auth H]IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
B [auth H]IPR051659Serine Protease S1 Domain-Containing ProteinFamily
B [auth H]IPR018056Kringle, conserved siteConserved Site
B [auth H]IPR013806Kringle-like foldHomologous Superfamily
B [auth H]IPR038178Kringle superfamilyHomologous Superfamily
B [auth H]IPR001314Peptidase S1A, chymotrypsin familyFamily
B [auth H]IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
IPR011061Hirudin/antistatinHomologous Superfamily
IPR000429Proteinase inhibitor I14, hirudinFamily
IPR024793Thrombin inhibitor hirudinHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth L]Pharos:  P00734
B [auth H]Pharos:  P00734

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
TYS Parent Component: TYR

RESID:  AA0172

PSI-MOD :  O4'-sulfo-L-tyrosine MOD:00181