6YH9

Crystal structure of chimeric carbonic anhydrase XII with 2,3,6-trifluoro-5-{[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino}-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6yh9a_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Carbonic anhydrase	8036258	3001672	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Carb_anhydrase	e6yh9A1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00194	Eukaryotic-type carbonic anhydrase (Carb_anhydrase)	Eukaryotic-type carbonic anhydrase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Carbonic anhydrase 2	cyanamide hydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity hydrolase activity, acting on ester bonds arylesterase activity carboxylic ester hydrolase activity hydrolase activity carbonate dehydratase activity cation binding transition metal ion binding zinc ion binding ion binding cyanamide hydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity hydrolase activity, acting on ester bonds arylesterase activity carboxylic ester hydrolase activity hydrolase activity carbonate dehydratase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	regulation of localization nitrogen compound transport regulation of dipeptide transmembrane transport regulation of cellular process regulation of dipeptide transport transport positive regulation of biological process oligopeptide transmembrane transport localization dipeptide transport amide transport regulation of oligopeptide transport positive regulation of transmembrane transport positive regulation of dipeptide transmembrane transport regulation of localization nitrogen compound transport regulation of dipeptide transmembrane transport regulation of cellular process regulation of dipeptide transport transport positive regulation of biological process oligopeptide transmembrane transport localization dipeptide transport amide transport regulation of oligopeptide transport positive regulation of transmembrane transport positive regulation of dipeptide transmembrane transport positive regulation of cellular process regulation of biological process regulation of transport oligopeptide transport regulation of peptide transport biological regulation establishment of localization peptide transport transmembrane transport regulation of transmembrane transport positive regulation of transport positive regulation of dipeptide transport positive regulation of oligopeptide transport cellular process dipeptide transmembrane transport secretion developmental process tissue morphogenesis anatomical structure morphogenesis epithelium development anatomical structure development morphogenesis of an epithelium tissue development positive regulation of cell communication signaling modulation of chemical synaptic transmission positive regulation of synaptic transmission, GABAergic cell communication synaptic signaling trans-synaptic signaling regulation of signaling synaptic transmission, GABAergic positive regulation of synaptic transmission cell-cell signaling chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication positive regulation of signaling regulation of synaptic transmission, GABAergic regulation of monoatomic ion transport regulation of monoatomic anion transport monoatomic anion transport monoatomic ion transport cellular response to nitrogen compound cellular response to stimulus response to angiotensin response to stimulus response to peptide hormone angiotensin-activated signaling pathway cellular response to angiotensin cellular response to endogenous stimulus response to hormone signal transduction cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical G protein-coupled receptor signaling pathway chloride transport regulation of chloride transport inorganic anion transport homeostatic process positive regulation of cellular pH reduction intracellular pH reduction regulation of intracellular pH cellular homeostasis chemical homeostasis regulation of cellular pH reduction intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis one-carbon compound transport gas transport carbon dioxide transport small molecule metabolic process metabolic process one-carbon metabolic process neuron cellular homeostasis	cellular anatomical structure myelin sheath apical part of cell extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical structure myelin sheath apical part of cell extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001148	Alpha carbonic anhydrase domain	Domain
A	IPR018338	Carbonic anhydrase, alpha-class, conserved site	Conserved Site
A	IPR036398	Alpha carbonic anhydrase domain superfamily	Homologous Superfamily
A	IPR023561	Carbonic anhydrase, alpha-class	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P00918	osteopetrosis autosomal recessive osteopetrosis 3 esophageal squamous cell carcinoma gastric cancer granular cell carcinoma tubular adenocarcinoma adenocarcinoma osteoporosis hepatocellular carcinoma Peripheral edema intellectual disability limb-girdle muscular dystrophy lung cancer angle-closure glaucoma malignant pancreatic neoplasm osteopetrosis autosomal recessive osteopetrosis 3 esophageal squamous cell carcinoma gastric cancer granular cell carcinoma tubular adenocarcinoma adenocarcinoma osteoporosis hepatocellular carcinoma Peripheral edema intellectual disability limb-girdle muscular dystrophy lung cancer angle-closure glaucoma malignant pancreatic neoplasm childhood absence epilepsy cystic fibrosis open-angle glaucoma pancreatic intraductal papillary-mucinous neoplasm gastric carcinoma renal tubular acidosis large cell medulloblastoma ulcerative colitis lung carcinoma malignant mesothelioma MALT lymphoma Barrett esophagus cribriform carcinoma non-small cell lung carcinoma Down syndrome exocrine pancreatic carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia gastric neoplasm pituitary cancer hereditary diffuse gastric adenocarcinoma Lennox-Gastaut syndrome tuberculosis lung adenocarcinoma malignant colon neoplasm asthma medulloblastoma breast cancer cribriform carcinoma of breast ocular hypertension Duchenne muscular dystrophy epilepsy with generalized tonic-clonic seizures

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.