6YJP

Crystal structure of a complex between glycosylated NKp30 and its deglycosylated tumour ligand B7-H6

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	C1-set	e6yjpC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
A [auth C]	I-set_7	e6yjpC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_7	ECOD (1.6)
E	C1-set	e6yjpE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
E	I-set_7	e6yjpE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_7	ECOD (1.6)
B [auth D]	C1-set	e6yjpD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
B [auth D]	I-set_7	e6yjpD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_7	ECOD (1.6)
C [auth A]	V-set_11	e6yjpA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_11	ECOD (1.6)
D [auth B]	V-set_11	e6yjpB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_11	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth D], E	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
C [auth A], D [auth B]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D], E	Natural cytotoxicity triggering receptor 3 ligand 1	protein binding binding signaling receptor binding immunoglobulin receptor binding antigen binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process immune response biological regulation immunoglobulin mediated immune response adaptive immune response immune effector process regulation of response to stimulus immune system process B cell mediated immunity regulation of immune response activation of immune response biological process involved in interspecies interaction between organisms response to other organism defense response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus	protein-containing complex extracellular region extracellular space cellular anatomical entity immunoglobulin complex, circulating immunoglobulin complex cell periphery plasma membrane membrane
C [auth A], D [auth B]	Natural cytotoxicity triggering receptor 3	identical protein binding protein binding binding	regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism regulation of innate immune response response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of response to stimulus defense response to other organism positive regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response positive regulation of natural killer cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus response to stress regulation of response to stress innate immune response positive regulation of immune effector process response to external biotic stimulus positive regulation of cellular process positive regulation of innate immune response defense response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont regulation of lymphocyte mediated immunity immune system process cellular process cell killing cellular response to stimulus immune response-regulating cell surface receptor signaling pathway signaling cell communication immune response-activating signaling pathway immune response-regulating signaling pathway signal transduction cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway activation of immune response multicellular organismal process cell activation natural killer cell activation lymphocyte activation leukocyte activation cell recognition inflammatory response	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth D], E	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth C], B [auth D], E	IPR050380	Immune Recognition and Response Modulators	Family
A [auth C], B [auth D], E	IPR003597	Immunoglobulin C1-set	Domain
A [auth C], B [auth D], E	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth C], B [auth D], E	IPR010999	Retroviral matrix protein	Homologous Superfamily
A [auth C], B [auth D], E	IPR036946	Gamma-retroviral matrix domain superfamily	Homologous Superfamily
A [auth C], B [auth D], E	IPR003599	Immunoglobulin domain subtype	Domain
A [auth C], B [auth D], E	IPR007110	Immunoglobulin-like domain	Domain
A [auth C], B [auth D], E	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
C [auth A], D [auth B]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR043226	Natural cytotoxicity triggering receptor 3	Family
C [auth A], D [auth B]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C [auth A], D [auth B]	IPR013106	Immunoglobulin V-set domain	Domain
C [auth A], D [auth B]	IPR003599	Immunoglobulin domain subtype	Domain
C [auth A], D [auth B]	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C], B [auth D], E	Pharos: Q68D85	psoriasis
C [auth A], D [auth B]	Pharos: O14931	malaria autism spectrum disorder Crohn disease Hashimoto thyroiditis laryngeal squamous cell carcinoma psoriatic arthritis Stevens-Johnson syndrome cancer cutaneous lupus erythematosus hypertensive disorder lung adenocarcinoma membranous glomerulonephritis rheumatoid arthritis tuberculosis cervical cancer malaria autism spectrum disorder Crohn disease Hashimoto thyroiditis laryngeal squamous cell carcinoma psoriatic arthritis Stevens-Johnson syndrome cancer cutaneous lupus erythematosus hypertensive disorder lung adenocarcinoma membranous glomerulonephritis rheumatoid arthritis tuberculosis cervical cancer Dengue hemorrhagic fever interstitial cystitis lung carcinoma myositis squamous cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.