6YNH
GAPDH purified from the supernatant of HEK293F cells: crystal form 4 of 4
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B [auth D] | SCOP2B Superfamily | GAPDH-like | 8044622 | 3000043 | SCOP2B (2022-06-29) |
C [auth F] | SCOP2B Superfamily | GAPDH-like | 8044622 | 3000043 | SCOP2B (2022-06-29) |
D [auth G] | SCOP2B Superfamily | GAPDH-like | 8044622 | 3000043 | SCOP2B (2022-06-29) |
A [auth B] | SCOP2B Superfamily | GAPDH-like | 8044622 | 3000043 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B [auth D] | Gp_dh_C | e6ynhD1 | A: a+b two layers | X: FwdE/GAPDH domain-like | H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology) | T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | F: Gp_dh_C | ECOD (1.6) |
B [auth D] | Gp_dh_N_2 | e6ynhD2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Gp_dh_N_2 | ECOD (1.6) |
C [auth F] | Gp_dh_C | e6ynhF2 | A: a+b two layers | X: FwdE/GAPDH domain-like | H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology) | T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | F: Gp_dh_C | ECOD (1.6) |
C [auth F] | Gp_dh_N_2 | e6ynhF1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Gp_dh_N_2 | ECOD (1.6) |
D [auth G] | Gp_dh_C | e6ynhG1 | A: a+b two layers | X: FwdE/GAPDH domain-like | H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology) | T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | F: Gp_dh_C | ECOD (1.6) |
D [auth G] | Gp_dh_N_2 | e6ynhG2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Gp_dh_N_2 | ECOD (1.6) |
A [auth B] | Gp_dh_C | e6ynhB2 | A: a+b two layers | X: FwdE/GAPDH domain-like | H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology) | T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | F: Gp_dh_C | ECOD (1.6) |
A [auth B] | Gp_dh_N_2 | e6ynhB1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Gp_dh_N_2 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth B], B [auth D], C [auth F], D [auth G] | PF02800 | Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (Gp_dh_C) | Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain | GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold. | Domain |
A [auth B], B [auth D], C [auth F], D [auth G] | PF00044 | Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain (Gp_dh_N) | Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain | GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. N-terminal domain is a Rossmann NAD(P) binding fold. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Pharos: Disease Associations Pharos Homepage Annotation
Protein Modification Annotation
Modified Residue(s) | ||
---|---|---|
Chain | Residue(s) | Description |
A [auth B], B [auth D], C [auth F], D [auth G] | CSU | Parent Component: CYS :  AA0171 :  S-sulfo-L-cysteine MOD:00180 |