6ZEG

Structure of PP1-IRSp53 chimera [PP1(7-304) + linker (G/S)x9 + IRSp53(449-465)] bound to Phactr1 (516-580)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Metallo-dependent phosphatases	8080445	3001067	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Metallo-dependent phosphatases	8080445	3001067	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Metallophos_2_1	e6zegA1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
C [auth B]	Metallophos_2_1	e6zegB1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF00149	Calcineurin-like phosphoesterase (Metallophos)	Calcineurin-like phosphoesterase	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or ...	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	Domain
A, C [auth B]	PF16891	Serine-threonine protein phosphatase N-terminal domain (STPPase_N)	Serine-threonine protein phosphatase N-terminal domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth C], D	Phosphatase and actin regulator	enzyme regulator activity phosphatase inhibitor activity molecular function inhibitor activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity protein phosphatase inhibitor activity enzyme inhibitor activity cytoskeletal protein binding actin binding protein binding binding	multicellular organismal process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation multicellular organismal process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization dendrite arborization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection arborization neuron development cellular process head development forebrain development animal organ development brain development pallium development cerebral cortex development central nervous system development telencephalon development actomyosin structure organization actin cytoskeleton organization actin filament organization cellular component biogenesis organelle organization cellular component assembly actin filament bundle organization contractile actin filament bundle assembly actin filament-based process actin filament bundle assembly stress fiber assembly supramolecular fiber organization cytoskeleton organization cell motility regulation of biological process regulation of cell motility regulation of cellular process neuron migration biological regulation regulation of neuron migration regulation of locomotion regulation of cell migration cell migration locomotion	synapse cell junction cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
A, C [auth B]	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit,Brain-specific angiogenesis inhibitor 1-associated protein 2	cell adhesion molecule binding cadherin binding involved in cell-cell adhesion cadherin binding protein binding binding cell adhesion mediator activity cell-cell adhesion mediator activity transcription factor binding transcription coregulator binding proline-rich region binding identical protein binding PDZ domain binding protein domain specific binding scaffold protein binding cell adhesion molecule binding cadherin binding involved in cell-cell adhesion cadherin binding protein binding binding cell adhesion mediator activity cell-cell adhesion mediator activity transcription factor binding transcription coregulator binding proline-rich region binding identical protein binding PDZ domain binding protein domain specific binding scaffold protein binding protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity cation binding transition metal ion binding ion binding metal ion binding small molecule binding ribonucleoprotein complex binding protein-containing complex binding myosin phosphatase activity protein phosphatase binding phosphatase binding protein phosphatase 1 binding enzyme binding iron ion binding	cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality positive regulation of cellular process trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling membrane organization cellular component organization plasma membrane organization cellular component organization or biogenesis endomembrane system organization axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cellular response to acid chemical cellular response to nitrogen compound cellular response to amino acid stimulus cellular response to L-glutamate response to oxygen-containing compound response to nitrogen compound response to amino acid cellular response to oxygen-containing compound response to acid chemical cellular response to chemical stimulus response to chemical response to L-glutamate organelle organization actin cytoskeleton organization actin filament organization actin filament-based process actin crosslink formation supramolecular fiber organization cytoskeleton organization positive regulation of dendritic spine morphogenesis positive regulation of nervous system development positive regulation of dendritic spine development regulation of cell differentiation regulation of neurogenesis regulation of cell morphogenesis regulation of cell development positive regulation of developmental process regulation of dendrite morphogenesis regulation of synapse structure or activity positive regulation of cell projection organization dendritic spine morphogenesis synapse organization dendritic spine development dendritic spine organization postsynapse organization regulation of cell projection organization positive regulation of cell development regulation of postsynapse organization positive regulation of cell morphogenesis regulation of dendrite development positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization regulation of developmental process regulation of dendritic spine development regulation of nervous system development dendrite development positive regulation of neuron projection development positive regulation of cell differentiation positive regulation of neurogenesis regulation of anatomical structure morphogenesis regulation of multicellular organismal development dendrite morphogenesis positive regulation of dendrite morphogenesis regulation of synapse organization cell junction organization regulation of dendritic spine morphogenesis neuron projection organization regulation of plasma membrane bounded cell projection organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of organelle organization regulation of actin cytoskeleton organization protein localization localization cellular localization protein localization to synapse cellular macromolecule localization macromolecule localization protein localization to cell junction regulation of cell shape response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus response to endogenous stimulus cellular response to peptide hormone stimulus response to insulin cellular response to insulin stimulus positive regulation of organelle organization regulation of cellular component size cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly positive regulation of protein polymerization protein-containing complex assembly regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin filament polymerization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization regulation of actin polymerization or depolymerization positive regulation of supramolecular fiber organization regulation of cellular component biogenesis regulation of protein polymerization regulation of actin filament length regulation of supramolecular fiber organization positive regulation of actin filament polymerization regulation of anatomical structure size regulation of synaptic plasticity cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus response to epidermal growth factor response to growth factor regulation of modification of postsynaptic actin cytoskeleton regulation of modification of synaptic structure modification of postsynaptic actin cytoskeleton regulation of modification of postsynaptic structure modification of synaptic structure modification of postsynaptic structure actin filament bundle organization actin filament bundle assembly regulation of Wnt signaling pathway regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway Wnt signaling pathway telomere maintenance in response to DNA damage telomere organization chromosome organization primary metabolic process DNA metabolic process nucleic acid metabolic process telomere maintenance nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process macromolecule metabolic process epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis tube morphogenesis morphogenesis of a branching structure epithelial tube morphogenesis morphogenesis of a branching epithelium regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds cellular biosynthetic process regulation of glucan biosynthetic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process regulation of primary metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process regulation of biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process cellular metabolic process glycogen metabolic process regulation of cellular metabolic process generation of precursor metabolites and energy regulation of macromolecule metabolic process glycogen biosynthetic process macromolecule biosynthetic process regulation of cellular biosynthetic process biosynthetic process regulation of polysaccharide biosynthetic process energy reserve metabolic process regulation of macromolecule biosynthetic process regulation of carbohydrate biosynthetic process regulation of glycogen metabolic process regulation of metabolic process rhythmic process circadian rhythm regulation of circadian rhythm cell division signal transduction in absence of ligand regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand positive regulation of programmed cell death regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway in absence of ligand apoptotic process programmed cell death regulation of apoptotic signaling pathway protein dephosphorylation dephosphorylation macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process animal organ development respiratory tube development lung development respiratory system development catabolic process carbohydrate catabolic process macromolecule catabolic process regulation of glycogen catabolic process glycogen catabolic process regulation of carbohydrate catabolic process glucan catabolic process regulation of catabolic process polysaccharide catabolic process circadian regulation of gene expression gene expression regulation of gene expression response to light stimulus entrainment of circadian clock response to external stimulus photoperiodism response to radiation response to abiotic stimulus entrainment of circadian clock by photoperiod response to metal ion response to lead ion post-transcriptional regulation of gene expression translational initiation regulation of translational initiation regulation of protein metabolic process translation regulation of translation	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle neuron projection neuron projection branch point intracellular anatomical structure cytoplasm cytosol intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle secretory granule secretory vesicle synapse cell junction glutamatergic synapse cell-cell junction adherens junction anchoring junction somatodendritic compartment dendrite dendritic tree dendritic shaft ruffle cell body neuronal cell body postsynaptic density, intracellular component postsynaptic specialization postsynaptic specialization, intracellular component postsynaptic density postsynapse neuron to neuron synapse intracellular non-membrane-bounded organelle asymmetric synapse non-membrane-bounded organelle actin-based cell projection filopodium polymeric cytoskeletal fiber cytoskeleton supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton cell periphery membrane plasma membrane plasma membrane region synaptic membrane cytosolic region presynapse presynaptic cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen neuron projection cytoplasm neuron spine cytoplasmic region plasma membrane bounded cell projection cytoplasm dendritic spine dendrite cytoplasm dendritic spine cytoplasm neuron projection terminus excitatory synapse Schaffer collateral - CA1 synapse postsynaptic cytosol nucleolus perikaryon phosphatase complex protein-containing complex protein phosphatase type 1 complex catalytic complex protein serine/threonine phosphatase complex PTW/PP1 phosphatase complex glycogen granule

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth C], D	IPR004018	RPEL repeat	Repeat
A, C [auth B]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, C [auth B]	IPR030128	BAR/IMD domain-containing adapter protein 2, I-BAR domain	Domain
A, C [auth B]	IPR001452	SH3 domain	Domain
A, C [auth B]	IPR027681	I-BAR domain containing protein IRSp53/IRTKS/Pinkbar	Family
A, C [auth B]	IPR013606	IMD/I-BAR domain	Domain
A, C [auth B]	IPR027267	AH/BAR domain superfamily	Homologous Superfamily
A, C [auth B]	IPR035594	BAR/IMD domain-containing adapter protein 2, SH3 domain	Domain
A, C [auth B]	IPR050341	Serine/threonine-protein phosphatase PP1 catalytic subunit	Family
A, C [auth B]	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
A, C [auth B]	IPR031675	Serine-threonine protein phosphatase, N-terminal	Domain
A, C [auth B]	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
A, C [auth B]	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth C], D	Pharos: Q9C0D0	myocardial infarction coronary artery disease migraine without aura, susceptibility to, 4 medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma arterial disorder Sjogren syndrome atypical teratoid rhabdoid tumor ulcerative colitis gastric carcinoma hepatocellular carcinoma lung adenocarcinoma malignant glioma myocardial infarction coronary artery disease migraine without aura, susceptibility to, 4 medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma arterial disorder Sjogren syndrome atypical teratoid rhabdoid tumor ulcerative colitis gastric carcinoma hepatocellular carcinoma lung adenocarcinoma malignant glioma migraine disorder non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor astrocytic tumor subependymal giant cell astrocytoma Cerebrovascular Trauma vascular brain injury epilepsy glioblastoma intellectual disability lung cancer malignant mesothelioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma Pick disease progressive supranuclear palsy attention deficit hyperactivity disorder, inattentive type tuberculosis gastric cancer heart disease large cell medulloblastoma malignant ependymoma
A, C [auth B]	Pharos: P62136	astrocytic tumor atypical teratoid rhabdoid tumor glioblastoma malignant glioma osteosarcoma pilocytic astrocytoma atopic eczema endogenous depression large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor attention deficit hyperactivity disorder, inattentive type esophageal adenocarcinoma malignant ependymoma astrocytic tumor atypical teratoid rhabdoid tumor glioblastoma malignant glioma osteosarcoma pilocytic astrocytoma atopic eczema endogenous depression large cell medulloblastoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor attention deficit hyperactivity disorder, inattentive type esophageal adenocarcinoma malignant ependymoma oligodendroglioma Pick disease psoriasis lung adenocarcinoma osteosarcoma severe acute respiratory syndrome lymphoplasmacytic lymphoma ovarian cancer Middle East respiratory syndrome plasma cell myeloma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.