6ZFA

Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with GlcIFG, alpha-1,2-mannobiose and hexatungstotellurate(VI) TEW

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth AAA]	SCOP2B Superfamily	(Trans)glycosidases	8101647	3000313	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth AAA]	Glyco_hydro_99	e6zfaAAA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_99	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA]	Glycoprotein endo-alpha-1,2-mannosidase	hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds mannosidase activity hydrolase activity alpha-mannosidase activity catalytic activity glycoprotein endo-alpha-1,2-mannosidase activity	-	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA]	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A [auth AAA]	IPR026071	Glycosyl hydrolase family 99	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth AAA]	Pharos: Q5SRI9	polycystic ovary syndrome cocaine abuse cocaine dependence Paranoid Disorders atypical teratoid rhabdoid tumor gastric carcinoma large cell medulloblastoma malignant glioma medulloblastoma pancreatic ductal adenocarcinoma pilocytic astrocytoma primitive neuroectodermal tumor Sjogren syndrome exocrine pancreatic carcinoma glioblastoma polycystic ovary syndrome cocaine abuse cocaine dependence Paranoid Disorders atypical teratoid rhabdoid tumor gastric carcinoma large cell medulloblastoma malignant glioma medulloblastoma pancreatic ductal adenocarcinoma pilocytic astrocytoma primitive neuroectodermal tumor Sjogren syndrome exocrine pancreatic carcinoma glioblastoma lung cancer nasopharyngeal carcinoma pituitary cancer sarcoidosis ulcerative colitis gastric cancer hepatocellular carcinoma malignant ependymoma malignant pancreatic neoplasm ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.